{"id":"https://openalex.org/W2049457697","doi":"https://doi.org/10.1053/gast.2003.50017","title":"Liver disease caused by failure to racemize trihydroxycholestanoic acid: Gene mutation and effect of bile acid therapy","display_name":"Liver disease caused by failure to racemize trihydroxycholestanoic acid: Gene mutation and effect of bile acid therapy","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2049457697","doi":"https://doi.org/10.1053/gast.2003.50017","mag":"2049457697","pmid":"https://pubmed.ncbi.nlm.nih.gov/12512044"},"language":"en","primary_location":{"id":"doi:10.1053/gast.2003.50017","doi":"https://doi.org/10.1053/gast.2003.50017","is_oa":true,"landing_page_url":"https://doi.org/10.1053/gast.2003.50017","pdf_url":"http://www.gastrojournal.org/article/S0016508503500336/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.gastrojournal.org/article/S0016508503500336/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036804110","display_name":"Kenneth D.R. Setchell","orcid":"https://orcid.org/0000-0001-9147-0136","observed_orcids":["https://orcid.org/0000-0001-9147-0136"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth D.R. Setchell","raw_affiliation_strings":["Division of Clinical Mass Spectrometry, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Kenneth_setchell@chmcc.org","Division of Clinical Mass Spectrometry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Mass Spectrometry, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Kenneth_setchell@chmcc.org","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Clinical Mass Spectrometry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110934638","display_name":"James E. Heubi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James E. Heubi","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107484438","display_name":"Kevin E. Bove","orcid":"https://orcid.org/0000-0003-4295-4921","observed_orcids":["https://orcid.org/0000-0003-4295-4921"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin E. Bove","raw_affiliation_strings":["Division of Pathology, Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109978118","display_name":"Nancy C. O\u2019Connell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy C. O'Connell","raw_affiliation_strings":["Division of Clinical Mass Spectrometry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Mass Spectrometry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063043931","display_name":"Tracy Brewsaugh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tracy Brewsaugh","raw_affiliation_strings":["Division of Clinical Mass Spectrometry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Mass Spectrometry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076318393","display_name":"Steven J. Steinberg","orcid":"https://orcid.org/0000-0001-7320-1426","observed_orcids":["https://orcid.org/0000-0001-7320-1426"]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J. Steinberg","raw_affiliation_strings":["Neurogenetics Department, Kennedy Krieger Institute and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Department, Kennedy Krieger Institute and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059798104","display_name":"Ann B. Moser","orcid":"https://orcid.org/0000-0002-9147-1902","observed_orcids":["https://orcid.org/0000-0002-9147-1902"]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Moser","raw_affiliation_strings":["Neurogenetics Department, Kennedy Krieger Institute and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Department, Kennedy Krieger Institute and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034686477","display_name":"Robert H. Squires","orcid":"https://orcid.org/0000-0002-7330-2961","observed_orcids":["https://orcid.org/0000-0002-7330-2961"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Squires","raw_affiliation_strings":["Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Texas Southwest Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Texas Southwest Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":6.2351,"has_fulltext":true,"cited_by_count":175,"citation_normalized_percentile":{"value":0.97735694,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"124","issue":"1","first_page":"217","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-cholestasis","display_name":"neonatal cholestasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/neonatal-hepatitis","display_name":"neonatal hepatitis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/bile-acid-synthesis","display_name":"bile acid synthesis","score":0.5920000076293945},{"id":"https://openalex.org/keywords/peroxisomal-beta-oxidation","display_name":"peroxisomal beta-oxidation","score":0.796999990940094},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.6489999890327454},{"id":"https://openalex.org/keywords/orthotopic-liver-transplantation","display_name":"orthotopic liver transplantation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/fat-soluble-vitamin-deficiency","display_name":"fat-soluble vitamin deficiency","score":0.7689999938011169},{"id":"https://openalex.org/keywords/zellweger-syndrome","display_name":"Zellweger syndrome","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.8043938875198364},{"id":"https://openalex.org/C2777485865","wikidata":"https://www.wikidata.org/wiki/Q189167","display_name":"Zellweger syndrome","level":4,"score":0.780897855758667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6529051661491394},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5693708062171936},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.5375049114227295},{"id":"https://openalex.org/C2780890998","wikidata":"https://www.wikidata.org/wiki/Q6993476","display_name":"Neonatal cholestasis","level":5,"score":0.5112810134887695},{"id":"https://openalex.org/C2775900799","wikidata":"https://www.wikidata.org/wiki/Q287415","display_name":"Cholic acid","level":3,"score":0.49814391136169434},{"id":"https://openalex.org/C7309524","wikidata":"https://www.wikidata.org/wiki/Q14905630","display_name":"CYP27A1","level":3,"score":0.4803953766822815},{"id":"https://openalex.org/C2781317408","wikidata":"https://www.wikidata.org/wiki/Q3281322","display_name":"Peroxisomal disorder","level":4,"score":0.4788218140602112},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4703056216239929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46699845790863037},{"id":"https://openalex.org/C512861765","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function tests","level":2,"score":0.4658295512199402},{"id":"https://openalex.org/C2781089062","wikidata":"https://www.wikidata.org/wiki/Q419028","display_name":"Chenodeoxycholic acid","level":3,"score":0.45656877756118774},{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.42687493562698364},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.41349080204963684},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.4102047085762024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36590686440467834},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.32689228653907776},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.24261704087257385},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.15468373894691467},{"id":"https://openalex.org/C2779243279","wikidata":"https://www.wikidata.org/wiki/Q659033","display_name":"Biliary atresia","level":4,"score":0.11682432889938354},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002777","descriptor_name":"Cholestanols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016339","descriptor_name":"Spectrometry, Mass, Fast Atom Bombardment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019998","descriptor_name":"Racemases and Epimerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020675","descriptor_name":"Peroxisomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1053/gast.2003.50017","doi":"https://doi.org/10.1053/gast.2003.50017","is_oa":true,"landing_page_url":"https://doi.org/10.1053/gast.2003.50017","pdf_url":"http://www.gastrojournal.org/article/S0016508503500336/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:12512044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12512044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1053/gast.2003.50017","doi":"https://doi.org/10.1053/gast.2003.50017","is_oa":true,"landing_page_url":"https://doi.org/10.1053/gast.2003.50017","pdf_url":"http://www.gastrojournal.org/article/S0016508503500336/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G1182838400","display_name":"General Clinical Research Center","funder_award_id":"M01RR008084","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1356466247","display_name":null,"funder_award_id":"FD R-000995","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"},{"id":"https://openalex.org/G1485156673","display_name":null,"funder_award_id":"P01 DK 46405","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000054694","display_name":null,"funder_award_id":"RR08084","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2049457697.pdf","grobid_xml":"https://content.openalex.org/works/W2049457697.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W74120669","https://openalex.org/W157316444","https://openalex.org/W575583463","https://openalex.org/W1438583999","https://openalex.org/W1504713469","https://openalex.org/W1513416306","https://openalex.org/W1527929042","https://openalex.org/W1539264366","https://openalex.org/W1566008008","https://openalex.org/W1572649633","https://openalex.org/W1577199596","https://openalex.org/W1596505093","https://openalex.org/W1750420467","https://openalex.org/W1938328095","https://openalex.org/W1942412916","https://openalex.org/W1963701113","https://openalex.org/W1968536438","https://openalex.org/W1971365801","https://openalex.org/W1972952356","https://openalex.org/W1973626559","https://openalex.org/W1974979173","https://openalex.org/W1976130670","https://openalex.org/W1990679871","https://openalex.org/W1993053439","https://openalex.org/W1994300680","https://openalex.org/W1995188759","https://openalex.org/W2001841129","https://openalex.org/W2008201698","https://openalex.org/W2010931272","https://openalex.org/W2012682463","https://openalex.org/W2013765069","https://openalex.org/W2015078614","https://openalex.org/W2021140965","https://openalex.org/W2024896041","https://openalex.org/W2029230351","https://openalex.org/W2030459443","https://openalex.org/W2042761114","https://openalex.org/W2049767461","https://openalex.org/W2053916731","https://openalex.org/W2058927589","https://openalex.org/W2059496748","https://openalex.org/W2059570890","https://openalex.org/W2066937635","https://openalex.org/W2081699761","https://openalex.org/W2093414096","https://openalex.org/W2096128316","https://openalex.org/W2098683962","https://openalex.org/W2100360692","https://openalex.org/W2106170859","https://openalex.org/W2123957814","https://openalex.org/W2129059830","https://openalex.org/W2134778685","https://openalex.org/W2135997554","https://openalex.org/W2141929879","https://openalex.org/W2147681614","https://openalex.org/W2158259814","https://openalex.org/W2182954198","https://openalex.org/W2257762101","https://openalex.org/W2265429262","https://openalex.org/W2268843310","https://openalex.org/W2323794713","https://openalex.org/W2324489854","https://openalex.org/W2329037174","https://openalex.org/W2340570492","https://openalex.org/W2341829121","https://openalex.org/W2344388674","https://openalex.org/W2404547429","https://openalex.org/W2414835998","https://openalex.org/W2416875492","https://openalex.org/W2462724581","https://openalex.org/W2798592060","https://openalex.org/W2805489052","https://openalex.org/W2886024925","https://openalex.org/W3145894777","https://openalex.org/W4211248395","https://openalex.org/W6674419767"],"related_works":["https://openalex.org/W2123957814","https://openalex.org/W2605214480","https://openalex.org/W7095922952","https://openalex.org/W4300858166","https://openalex.org/W1987325449","https://openalex.org/W4319344961","https://openalex.org/W4311714638","https://openalex.org/W2149063676","https://openalex.org/W2129059830","https://openalex.org/W2031665015"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
