{"id":"https://openalex.org/W2049385227","doi":"https://doi.org/10.1016/j.bbrc.2004.12.138","title":"Indole-3-carbinol and 3,3\u2032-diindolylmethane induce expression of NAG-1 in a p53-independent manner","display_name":"Indole-3-carbinol and 3,3\u2032-diindolylmethane induce expression of NAG-1 in a p53-independent manner","publication_year":2005,"publication_date":"2005-01-06","ids":{"openalex":"https://openalex.org/W2049385227","doi":"https://doi.org/10.1016/j.bbrc.2004.12.138","mag":"2049385227","pmid":"https://pubmed.ncbi.nlm.nih.gov/15670751"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2004.12.138","doi":"https://doi.org/10.1016/j.bbrc.2004.12.138","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2004.12.138","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031414863","display_name":"Seong\u2010Ho Lee","orcid":"https://orcid.org/0000-0001-5876-1396","observed_orcids":["https://orcid.org/0000-0001-5876-1396"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seong-Ho Lee","raw_affiliation_strings":["Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074896786","display_name":"Jong\u2010Sik Kim","orcid":"https://orcid.org/0000-0003-2248-2576","observed_orcids":["https://orcid.org/0000-0003-2248-2576"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jong-Sik Kim","raw_affiliation_strings":["Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015396057","display_name":"Kiyoshi Yamaguchi","orcid":"https://orcid.org/0000-0003-2113-4369","observed_orcids":["https://orcid.org/0000-0003-2113-4369"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiyoshi Yamaguchi","raw_affiliation_strings":["Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064125146","display_name":"Thomas E. Eling","orcid":"https://orcid.org/0009-0006-5980-1189","observed_orcids":["https://orcid.org/0009-0006-5980-1189"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Eling","raw_affiliation_strings":["Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009464125","display_name":"Seung Joon Baek","orcid":"https://orcid.org/0000-0001-7866-7778","observed_orcids":["https://orcid.org/0000-0001-7866-7778"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seung Joon Baek","raw_affiliation_strings":["Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009464125"],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":3.9742,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.95079417,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"328","issue":"1","first_page":"63","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indole-3-carbinol","display_name":"indole-3-carbinol","score":1.0},{"id":"https://openalex.org/keywords/3-3-diindolylmethane","display_name":"3,3'-diindolylmethane","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nag-1","display_name":"NAG-1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/atf3","display_name":"ATF3","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p53-independent-regulation","display_name":"p53-independent regulation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6380000114440918},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.7170000076293945},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.6629999876022339},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.7080000042915344},{"id":"https://openalex.org/keywords/anti-tumorigenic-activity","display_name":"anti-tumorigenic activity","score":0.6209999918937683},{"id":"https://openalex.org/keywords/cruciferous-vegetables","display_name":"cruciferous vegetables","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5916273593902588},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.5842880606651306},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5402519106864929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5340062379837036},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5287648439407349},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.513179361820221},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5085529088973999},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.49401575326919556},{"id":"https://openalex.org/C157880135","wikidata":"https://www.wikidata.org/wiki/Q17832633","display_name":"ATF3","level":5,"score":0.48457372188568115},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.43592146039009094},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4309343695640564},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4121054410934448},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34278249740600586},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32943493127822876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32235389947891235},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.28453290462493896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17172223329544067}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051700","descriptor_name":"Activating Transcription Factor 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055436","descriptor_name":"Growth Differentiation Factor 15","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2004.12.138","doi":"https://doi.org/10.1016/j.bbrc.2004.12.138","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2004.12.138","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:15670751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15670751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1966773608","https://openalex.org/W1969094464","https://openalex.org/W1976616876","https://openalex.org/W1977621160","https://openalex.org/W1979805598","https://openalex.org/W1989468717","https://openalex.org/W1991395966","https://openalex.org/W2010581370","https://openalex.org/W2016792047","https://openalex.org/W2017022701","https://openalex.org/W2021353749","https://openalex.org/W2024890638","https://openalex.org/W2031760644","https://openalex.org/W2044261960","https://openalex.org/W2053042661","https://openalex.org/W2054183406","https://openalex.org/W2054861419","https://openalex.org/W2055433382","https://openalex.org/W2056615719","https://openalex.org/W2063058393","https://openalex.org/W2063815648","https://openalex.org/W2065858724","https://openalex.org/W2076571195","https://openalex.org/W2077613098","https://openalex.org/W2078318155","https://openalex.org/W2085595936","https://openalex.org/W2086057653","https://openalex.org/W2086761959","https://openalex.org/W2088844005","https://openalex.org/W2089001391","https://openalex.org/W2089343966","https://openalex.org/W2105541913","https://openalex.org/W2106787323","https://openalex.org/W2109560931","https://openalex.org/W2109613368","https://openalex.org/W2126294962","https://openalex.org/W2126527070","https://openalex.org/W2127404943","https://openalex.org/W2133252611","https://openalex.org/W2138563742","https://openalex.org/W2142353680","https://openalex.org/W2145028201","https://openalex.org/W2160657822","https://openalex.org/W2338655541","https://openalex.org/W2409083122","https://openalex.org/W4255483444","https://openalex.org/W6676650166","https://openalex.org/W6678609161"],"related_works":["https://openalex.org/W1569761498","https://openalex.org/W2005324267","https://openalex.org/W2733734673","https://openalex.org/W7096371191","https://openalex.org/W1980537841","https://openalex.org/W4386191936","https://openalex.org/W2043620261","https://openalex.org/W2164048268","https://openalex.org/W4293203332","https://openalex.org/W1969989426"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}