{"id":"https://openalex.org/W2049375392","doi":"https://doi.org/10.1523/jneurosci.0313-14.2014","title":"The Acquisition of Goal-Directed Actions Generates Opposing Plasticity in Direct and Indirect Pathways in Dorsomedial Striatum","display_name":"The Acquisition of Goal-Directed Actions Generates Opposing Plasticity in Direct and Indirect Pathways in Dorsomedial Striatum","publication_year":2014,"publication_date":"2014-07-09","ids":{"openalex":"https://openalex.org/W2049375392","doi":"https://doi.org/10.1523/jneurosci.0313-14.2014","mag":"2049375392","pmid":"https://pubmed.ncbi.nlm.nih.gov/25009253","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608360"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0313-14.2014","doi":"https://doi.org/10.1523/jneurosci.0313-14.2014","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0313-14.2014","pdf_url":"https://www.jneurosci.org/content/jneuro/34/28/9196.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jneurosci.org/content/jneuro/34/28/9196.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016587132","display_name":"Qiang Shan","orcid":"https://orcid.org/0000-0002-7717-2922","observed_orcids":["https://orcid.org/0000-0002-7717-2922"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Q. Shan","raw_affiliation_strings":["Behavioural Neuroscience Laboratory, Brain & Mind Research Institute, University of Sydney, NSW 2006, Australia, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioural Neuroscience Laboratory, Brain & Mind Research Institute, University of Sydney, NSW 2006, Australia, and","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. Ge","raw_affiliation_strings":["Behavioural Neuroscience Laboratory, Brain & Mind Research Institute, University of Sydney, NSW 2006, Australia, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioural Neuroscience Laboratory, Brain & Mind Research Institute, University of Sydney, NSW 2006, Australia, and","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032114486","display_name":"MacDonald J. Christie","orcid":"https://orcid.org/0000-0002-0622-609X","observed_orcids":["https://orcid.org/0000-0002-0622-609X"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. J. Christie","raw_affiliation_strings":["Discipline of Pharmacology, University of Sydney, NSW 2006, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Pharmacology, University of Sydney, NSW 2006, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087840723","display_name":"Bernard W. Balleine","orcid":"https://orcid.org/0000-0001-8618-7950","observed_orcids":["https://orcid.org/0000-0001-8618-7950"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"B. W. Balleine","raw_affiliation_strings":["Behavioural Neuroscience Laboratory, Brain & Mind Research Institute, University of Sydney, NSW 2006, Australia, and bernard.balleine@sydney.edu.au","Behavioural Neuroscience Laboratory, Brain & Mind Research Institute, University of Sydney, NSW 2006, Australia, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioural Neuroscience Laboratory, Brain & Mind Research Institute, University of Sydney, NSW 2006, Australia, and bernard.balleine@sydney.edu.au","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Behavioural Neuroscience Laboratory, Brain & Mind Research Institute, University of Sydney, NSW 2006, Australia, and","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":null,"apc_paid":null,"fwci":3.7928,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.94748076,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"34","issue":"28","first_page":"9196","last_page":"9201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.4884999990463257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.4884999990463257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2953999936580658,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.15520000457763672,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/goal-directed-action","display_name":"goal-directed action","score":0.7490000128746033},{"id":"https://openalex.org/keywords/dorsomedial-striatum","display_name":"dorsomedial striatum","score":0.9649999737739563},{"id":"https://openalex.org/keywords/striatal-plasticity","display_name":"striatal plasticity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/striatonigral-neurons","display_name":"striatonigral neurons","score":0.8169999718666077},{"id":"https://openalex.org/keywords/striatopallidal-neurons","display_name":"striatopallidal neurons","score":1.0},{"id":"https://openalex.org/keywords/medium-spiny-neurons","display_name":"medium spiny neurons","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.8069999814033508},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":1.0},{"id":"https://openalex.org/keywords/ampa-nmda-ratio","display_name":"AMPA/NMDA ratio","score":0.8870000243186951},{"id":"https://openalex.org/keywords/learning","display_name":"learning","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.822124719619751},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.7773879766464233},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.7596372961997986},{"id":"https://openalex.org/C148132819","wikidata":"https://www.wikidata.org/wiki/Q5280374","display_name":"Direct pathway of movement","level":4,"score":0.7248837947845459},{"id":"https://openalex.org/C85714458","wikidata":"https://www.wikidata.org/wiki/Q17152690","display_name":"Medium spiny neuron","level":4,"score":0.69370436668396},{"id":"https://openalex.org/C162536842","wikidata":"https://www.wikidata.org/wiki/Q6025117","display_name":"Indirect pathway of movement","level":4,"score":0.6465517282485962},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.615409791469574},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.5764041543006897},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.524055004119873},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4969921410083771},{"id":"https://openalex.org/C107690735","wikidata":"https://www.wikidata.org/wiki/Q852461","display_name":"Motor learning","level":2,"score":0.4204099774360657},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.4190056622028351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3725072145462036},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.28175482153892517},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19942444562911987},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17629432678222656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003216","descriptor_name":"Conditioning, Operant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006040","descriptor_name":"Goals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.0313-14.2014","doi":"https://doi.org/10.1523/jneurosci.0313-14.2014","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0313-14.2014","pdf_url":"https://www.jneurosci.org/content/jneuro/34/28/9196.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6608360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608360","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:25009253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25009253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0313-14.2014","doi":"https://doi.org/10.1523/jneurosci.0313-14.2014","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0313-14.2014","pdf_url":"https://www.jneurosci.org/content/jneuro/34/28/9196.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3907066071","display_name":"Action-related learning and plasticity in the cortico-striatal network","funder_award_id":"DP110105636","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2049375392.pdf","grobid_xml":"https://content.openalex.org/works/W2049375392.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W150521681","https://openalex.org/W1971501199","https://openalex.org/W1971797700","https://openalex.org/W2017400430","https://openalex.org/W2017599623","https://openalex.org/W2022633426","https://openalex.org/W2022709265","https://openalex.org/W2024365408","https://openalex.org/W2031170958","https://openalex.org/W2031898618","https://openalex.org/W2032057219","https://openalex.org/W2033513858","https://openalex.org/W2033717313","https://openalex.org/W2036952324","https://openalex.org/W2043292527","https://openalex.org/W2055523610","https://openalex.org/W2057001461","https://openalex.org/W2057029832","https://openalex.org/W2059905238","https://openalex.org/W2060588252","https://openalex.org/W2061863046","https://openalex.org/W2066577814","https://openalex.org/W2067690062","https://openalex.org/W2075361934","https://openalex.org/W2086614467","https://openalex.org/W2089164910","https://openalex.org/W2090227765","https://openalex.org/W2098526280","https://openalex.org/W2108366837","https://openalex.org/W2112337921","https://openalex.org/W2114586089","https://openalex.org/W2118691301","https://openalex.org/W2118830830","https://openalex.org/W2129084135","https://openalex.org/W2144623340","https://openalex.org/W2316954075","https://openalex.org/W4237434319","https://openalex.org/W4246659915"],"related_works":["https://openalex.org/W3090518206","https://openalex.org/W3098022599","https://openalex.org/W6889777546","https://openalex.org/W3143426192","https://openalex.org/W3003973921","https://openalex.org/W2776440111","https://openalex.org/W4409246788","https://openalex.org/W2140925579","https://openalex.org/W3139795701","https://openalex.org/W6958812059"],"abstract_inverted_index":{"A":[0],"cortical-basal":[1],"ganglia":[2],"network":[3],"involving,":[4],"particularly,":[5],"the":[6,17,65,84,98,120,123,130,135],"posterior":[7],"region":[8,32],"of":[9,19,26,57,60,86,137],"dorsomedial":[10],"striatum":[11,53],"(DMS)":[12],"has":[13,33],"been":[14,34],"implicated":[15],"in":[16,29,48,82,91,97,106,115,119,122],"acquisition":[18,85],"goal-directed":[20,87],"actions;":[21],"however,":[22],"no":[23],"direct":[24],"evidence":[25],"learning-related":[27],"plasticity":[28,90,127],"this":[30,49],"striatal":[31,148],"reported,":[35],"nor":[36],"is":[37,54],"it":[38],"known":[39],"whether,":[40],"or":[41],"which,":[42],"specific":[43],"cell":[44],"types":[45],"are":[46],"involved":[47],"learning":[50],"process.":[51],"The":[52],"primarily":[55],"composed":[56],"two":[58],"classes":[59],"spiny":[61],"projection":[62],"neurons":[63],"(SPNs):":[64],"striatonigral":[66],"and":[67,74,94,117,140],"striatopallidal":[68],"SPNs,":[69],"which":[70],"express":[71],"dopamine":[72],"D1":[73],"D2":[75],"receptors,":[76],"respectively.":[77],"Here":[78],"we":[79],"establish":[80],"that,":[81],"mice,":[83],"actions":[88],"induced":[89],"both":[92],"D1-":[93],"D2-SPNs":[95,121],"specifically":[96],"DMS":[99],"and,":[100],"importantly,":[101],"that":[102],"these":[103],"changes":[104],"were":[105,113],"opposing":[107,126],"directions;":[108],"after":[109],"learning,":[110],"AMPA/NMDA":[111],"ratios":[112],"increased":[114],"D1-SPNs":[116],"reduced":[118],"DMS.":[124],"Such":[125],"could":[128,143],"provide":[129],"basis":[131],"for":[132],"rapidly":[133],"rebiasing":[134],"control":[136],"task-specific":[138],"actions,":[139],"its":[141],"dysregulation":[142],"underlie":[144],"disorders":[145],"associated":[146],"with":[147],"function.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}