{"id":"https://openalex.org/W2049167103","doi":"https://doi.org/10.1097/qad.0b013e32832ba904","title":"Effects of switching from lopinavir/ritonavir to atazanavir/ritonavir on muscle glucose uptake and visceral fat in HIV-infected patients","display_name":"Effects of switching from lopinavir/ritonavir to atazanavir/ritonavir on muscle glucose uptake and visceral fat in HIV-infected patients","publication_year":2009,"publication_date":"2009-06-29","ids":{"openalex":"https://openalex.org/W2049167103","doi":"https://doi.org/10.1097/qad.0b013e32832ba904","mag":"2049167103","pmid":"https://pubmed.ncbi.nlm.nih.gov/19474651","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2886977"},"language":"en","primary_location":{"id":"doi:10.1097/qad.0b013e32832ba904","doi":"https://doi.org/10.1097/qad.0b013e32832ba904","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0b013e32832ba904","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2886977","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034813577","display_name":"Takara Leah Stanley","orcid":"https://orcid.org/0000-0002-2336-2958","observed_orcids":["https://orcid.org/0000-0002-2336-2958"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takara L Stanley","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA","Program in Nutritional Metabolism, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Nutritional Metabolism, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015773345","display_name":"TISHA R. JOY","orcid":"https://orcid.org/0009-0001-0379-4497","observed_orcids":["https://orcid.org/0009-0001-0379-4497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tisha Joy","raw_affiliation_strings":["Program in Nutritional Metabolism, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Nutritional Metabolism, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049246976","display_name":"Colleen M. Hadigan","orcid":"https://orcid.org/0000-0003-0642-7817","observed_orcids":["https://orcid.org/0000-0003-0642-7817"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen M Hadigan","raw_affiliation_strings":["National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075346163","display_name":"James Liebau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James G Liebau","raw_affiliation_strings":["Program in Nutritional Metabolism, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Nutritional Metabolism, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053884502","display_name":"Hideo Makimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideo Makimura","raw_affiliation_strings":["Program in Nutritional Metabolism, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Nutritional Metabolism, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cindy Y Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cindy Y Chen","raw_affiliation_strings":["Program in Nutritional Metabolism, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Nutritional Metabolism, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086075176","display_name":"Bijoy J. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bijoy J Thomas","raw_affiliation_strings":["Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110070383","display_name":"Steven B. Weise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven B Weise","raw_affiliation_strings":["Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035636543","display_name":"Gregory K. Robbins","orcid":"https://orcid.org/0000-0001-7545-5817","observed_orcids":["https://orcid.org/0000-0001-7545-5817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory K Robbins","raw_affiliation_strings":["Division of Infectious Diseases, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063043469","display_name":"Steven Kyle Grinspoon","orcid":"https://orcid.org/0000-0002-6338-000X","observed_orcids":["https://orcid.org/0000-0002-6338-000X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven K Grinspoon","raw_affiliation_strings":["Program in Nutritional Metabolism, USA","to Steven K. Grinspoon, MD, Director, Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, MA 02114, USA. Tel: +1 617 724 9109; fax: +1 617 724 8998; e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Nutritional Metabolism, USA","institution_ids":[]},{"raw_affiliation_string":"to Steven K. Grinspoon, MD, Director, Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, MA 02114, USA. Tel: +1 617 724 9109; fax: +1 617 724 8998; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063043469"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":10.0988,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.97964116,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"11","first_page":"1349","last_page":"1357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lopinavir-ritonavir","display_name":"lopinavir/ritonavir","score":0.9380000233650208},{"id":"https://openalex.org/keywords/atazanavir-ritonavir","display_name":"atazanavir/ritonavir","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.8180000185966492},{"id":"https://openalex.org/keywords/antiretroviral-therapy-switching","display_name":"antiretroviral therapy switching","score":0.8149999976158142},{"id":"https://openalex.org/keywords/muscle-glucose-uptake","display_name":"muscle glucose uptake","score":0.9160000085830688},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.7820000052452087},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.7940000295639038},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6769999861717224},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.7310000061988831},{"id":"https://openalex.org/keywords/hiv-associated-lipodystrophy","display_name":"HIV-associated lipodystrophy","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2781392899","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Lopinavir/ritonavir","level":5,"score":0.8628554344177246},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.8540695905685425},{"id":"https://openalex.org/C2777182164","wikidata":"https://www.wikidata.org/wiki/Q422585","display_name":"Lopinavir","level":5,"score":0.7479954361915588},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5714090466499329},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5469607710838318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5428599715232849},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5186378359794617},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4763225018978119},{"id":"https://openalex.org/C2778414717","wikidata":"https://www.wikidata.org/wiki/Q423467","display_name":"Atazanavir","level":5,"score":0.4668389558792114},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.44849586486816406},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4404796063899994},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3474002480506897},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.29736393690109253},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.2175264060497284},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.15033137798309326},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.14293524622917175},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0950666069984436},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069446","descriptor_name":"Atazanavir Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050152","descriptor_name":"Intra-Abdominal Fat","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061466","descriptor_name":"Lopinavir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/qad.0b013e32832ba904","doi":"https://doi.org/10.1097/qad.0b013e32832ba904","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0b013e32832ba904","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},{"id":"pmid:19474651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19474651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2886977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2886977","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"AIDS","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2886977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2886977","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"AIDS","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1290643946","display_name":null,"funder_award_id":"K01 AI-062435","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1817153103","display_name":"Training Program in Nutrition and Metabolism","funder_award_id":"T32HD052961","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3447108572","display_name":"Harvard Clinical and Translational Science Center (UL1)","funder_award_id":"UL1RR025758","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"M01RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7495689722","display_name":"Strategies to Improve CAD Risk In HIV Disease","funder_award_id":"K24DK064545","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000907652","display_name":"Boston Area Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK040561","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G970039434","display_name":"Bridging the Gap HIV Trials and Clinical Practice","funder_award_id":"5k01ai062435-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306493","display_name":"Abbott Laboratories","ror":"https://ror.org/0052svj16"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320309673","display_name":"Harvard Catalyst","ror":null},{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1967632729","https://openalex.org/W1968485058","https://openalex.org/W1974137440","https://openalex.org/W1988354903","https://openalex.org/W2004648941","https://openalex.org/W2006152240","https://openalex.org/W2011910958","https://openalex.org/W2031109520","https://openalex.org/W2038510867","https://openalex.org/W2045131275","https://openalex.org/W2046894504","https://openalex.org/W2058217770","https://openalex.org/W2058588784","https://openalex.org/W2069960997","https://openalex.org/W2084608105","https://openalex.org/W2091239171","https://openalex.org/W2094372957","https://openalex.org/W2103115713","https://openalex.org/W2105912552","https://openalex.org/W2106650290","https://openalex.org/W2122280827","https://openalex.org/W2122623377","https://openalex.org/W2122944706","https://openalex.org/W2124367104","https://openalex.org/W2143810793","https://openalex.org/W2145982785","https://openalex.org/W2147357250","https://openalex.org/W2157138119","https://openalex.org/W2161139221","https://openalex.org/W2163617802","https://openalex.org/W2164109956","https://openalex.org/W2164676747","https://openalex.org/W2165696569","https://openalex.org/W2171236519","https://openalex.org/W2339057709","https://openalex.org/W2414699286","https://openalex.org/W4232245631"],"related_works":["https://openalex.org/W2001105266","https://openalex.org/W2291356096","https://openalex.org/W1989254795","https://openalex.org/W1974176206","https://openalex.org/W2154760064","https://openalex.org/W2414699286","https://openalex.org/W2045813763","https://openalex.org/W1988101744","https://openalex.org/W1991551730","https://openalex.org/W2088339272"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"the":[3],"effects":[4],"of":[5,37,99],"switching":[6],"from":[7,226],"lopinavir/ritonavir":[8],"(LPV/r)":[9],"to":[10,43,47,49,102,146,161,210,228],"atazanavir/ritonavir":[11],"(ATV/r)":[12],"on":[13,29],"muscle":[14,69,116],"glucose":[15,17,70,117,204,232,247],"uptake,":[16],"homeostasis,":[18],"lipids,":[19,86],"and":[20,27,34,54,87,135,178,196,244],"body":[21],"composition.":[22],"METHODS:":[23],"Fifteen":[24],"HIV-infected":[25],"men":[26],"women":[28],"a":[30],"regimen":[31],"containing":[32],"LPV/r":[33,45,227],"with":[35],"evidence":[36],"hyperinsulinemia":[38],"and/or":[39],"dyslipidemia":[40],"were":[41],"randomized":[42],"continue":[44],"or":[46],"switch":[48,209],"ATV/r":[50,100,129,147,154,162,172,187,211,218,229],"(ATV":[51],"300":[52],"mg":[53,57],"ritonavir":[55],"100":[56],"daily)":[58],"for":[59],"6":[60,112,249],"months.":[61,250],"The":[62,90],"primary":[63],"endpoint":[64],"was":[65,104],"change":[66,201],"in":[67,142],"thigh":[68,115],"uptake":[71,118,233],"as":[72],"measured":[73],"by":[74,106,234],"positron":[75],"emission":[76],"tomography.":[77],"Secondary":[78],"endpoints":[79],"included":[80],"abdominal":[81,237],"visceral":[82,136,238],"adipose":[83,137,239],"tissue,":[84,240],"fasting":[85,246],"safety":[88],"parameters.":[89],"difference":[91],"over":[92,248],"time":[93],"between":[94],"treatment":[95],"groups":[96],"(treatment":[97,121,148,166,181,212],"effect":[98,122,149,167,182,213],"relative":[101],"LPV/r)":[103],"determined":[105],"repeated":[107],"measures":[108],"ANCOVA.":[109],"RESULTS:":[110],"After":[111],"months,":[113],"anterior":[114],"increased":[119],"significantly":[120,141,163,207,230],"+18.2":[123],"+/-":[124,151,169,184,215],"5.9":[125],"micromol/kg":[126],"per":[127],"min,":[128],"vs.":[130,155,173,188,219],"LPV/r,":[131,156,174,189,220],"P":[132,157,175,190,221],"=":[133,158,176,191,222],"0.035),":[134],"tissue":[138],"area":[139],"decreased":[140,164,206],"individuals":[143],"who":[144],"switched":[145],"-31":[150],"11":[152],"cm,":[153],"0.047).":[159],"Switching":[160,225],"triglyceride":[165],"-182":[168],"64":[170],"mg/dl,":[171,186,217],"0.02)":[177],"total":[179],"cholesterol":[180],"-23":[183],"8":[185],"0.01),":[192],"whereas":[193],"high-density":[194],"lipoprotein":[195,198],"low-density":[197],"did":[199],"not":[200],"significantly.":[202],"Fasting":[203],"also":[205],"following":[208],"-15":[214],"4":[216],"0.002).":[223],"CONCLUSION:":[224],"increases":[231],"muscle,":[235],"decreases":[236,245],"improves":[241],"lipid":[242],"parameters,":[243]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}