{"id":"https://openalex.org/W2049091074","doi":"https://doi.org/10.1016/s1557-9190(11)70744-2","title":"B469 Unraveling the Synergism of Nab-Rapamycin and Perifosine Combination in Multiple Myeloma","display_name":"B469 Unraveling the Synergism of Nab-Rapamycin and Perifosine Combination in Multiple Myeloma","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W2049091074","doi":"https://doi.org/10.1016/s1557-9190(11)70744-2","mag":"2049091074"},"language":"en","primary_location":{"id":"doi:10.1016/s1557-9190(11)70744-2","doi":"https://doi.org/10.1016/s1557-9190(11)70744-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1557-9190(11)70744-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210172855","display_name":"Clinical Lymphoma & Myeloma","issn_l":"1557-9190","issn":["1557-9190","1938-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma and Myeloma","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083655413","display_name":"Diana D. Cirstea","orcid":"https://orcid.org/0000-0002-5719-581X","observed_orcids":["https://orcid.org/0000-0002-5719-581X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Cirstea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091207345","display_name":"Teru Hideshima","orcid":"https://orcid.org/0000-0003-2939-6224","observed_orcids":["https://orcid.org/0000-0003-2939-6224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hideshima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058975989","display_name":"Scott J. Rodig","orcid":"https://orcid.org/0000-0003-1761-9769","observed_orcids":["https://orcid.org/0000-0003-1761-9769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rodig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009254009","display_name":"Sabina Pozzi","orcid":"https://orcid.org/0000-0002-6299-9273","observed_orcids":["https://orcid.org/0000-0002-6299-9273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Pozzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090686439","display_name":"Sonia Vallet","orcid":"https://orcid.org/0000-0003-0146-8089","observed_orcids":["https://orcid.org/0000-0003-0146-8089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Vallet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Ikeda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Ikeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101433909","display_name":"Loredana Santo","orcid":"https://orcid.org/0000-0002-8829-4191","observed_orcids":["https://orcid.org/0000-0002-8829-4191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Santo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113670374","display_name":"Nital N. Vaghela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Vaghela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039749707","display_name":"Gabriela Motyckova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Motyckova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084530923","display_name":"Yutaka Okawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Okawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016860333","display_name":"Giulia Perrone","orcid":"https://orcid.org/0000-0002-4312-0577","observed_orcids":["https://orcid.org/0000-0002-4312-0577"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Perrone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049134468","display_name":"G\u00fcll\u00fc G\u00f6rg\u00fcn","orcid":"https://orcid.org/0000-0001-9875-8394","observed_orcids":["https://orcid.org/0000-0001-9875-8394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Gorgun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056860535","display_name":"Elisabetta Calabrese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Calabrese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030043230","display_name":"Treeve Currie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Currie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059615305","display_name":"Vuong N. Trieu","orcid":"https://orcid.org/0000-0002-6675-0811","observed_orcids":["https://orcid.org/0000-0002-6675-0811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Trieu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037392395","display_name":"Nikesh Desai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Desai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074058246","display_name":"Peter Sportelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Sportelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NC Munshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KC Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069645152","display_name":"N. S. Raje","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Raje","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":null,"first_page":"S138","last_page":"S139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.7929999828338623},{"id":"https://openalex.org/keywords/perifosine","display_name":"perifosine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5759999752044678},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pi3k-akt-inhibition","display_name":"PI3K/AKT inhibition","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6788609027862549},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43433475494384766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35663723945617676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22899463772773743}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1557-9190(11)70744-2","doi":"https://doi.org/10.1016/s1557-9190(11)70744-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1557-9190(11)70744-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210172855","display_name":"Clinical Lymphoma & Myeloma","issn_l":"1557-9190","issn":["1557-9190","1938-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma and Myeloma","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W164217829","https://openalex.org/W4211054478","https://openalex.org/W1978882275","https://openalex.org/W2463874419","https://openalex.org/W4205892091","https://openalex.org/W2140359211","https://openalex.org/W2411851931","https://openalex.org/W2498099382","https://openalex.org/W2601381641","https://openalex.org/W2322662982"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}