{"id":"https://openalex.org/W2049033332","doi":"https://doi.org/10.1210/jc.75.2.524","title":"Epidemiology of menarche and menstrual disturbances in an unselected group of women with insulin-dependent diabetes mellitus compared to controls","display_name":"Epidemiology of menarche and menstrual disturbances in an unselected group of women with insulin-dependent diabetes mellitus compared to controls","publication_year":1992,"publication_date":"1992-08-01","ids":{"openalex":"https://openalex.org/W2049033332","doi":"https://doi.org/10.1210/jc.75.2.524","mag":"2049033332","pmid":"https://pubmed.ncbi.nlm.nih.gov/1639955"},"language":"en","primary_location":{"id":"doi:10.1210/jc.75.2.524","doi":"https://doi.org/10.1210/jc.75.2.524","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.75.2.524","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044629674","display_name":"Karen Kj\u00e6r","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"K Kjaer","raw_affiliation_strings":["Department of Internal Medicine and Endocrinology, Odense University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Endocrinology, Odense University Hospital, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077029779","display_name":"Claus Hagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"C Hagen","raw_affiliation_strings":["Department of Internal Medicine and Endocrinology, Odense University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Endocrinology, Odense University Hospital, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027935500","display_name":"S. H. Sand\u00f8","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S H Sand\u00f8","raw_affiliation_strings":["Department of Internal Medicine and Endocrinology, Odense University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Endocrinology, Odense University Hospital, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071275736","display_name":"Ole Esh\u00f8j","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"O Esh\u00f8j","raw_affiliation_strings":["Department of Internal Medicine and Endocrinology, Odense University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Endocrinology, Odense University Hospital, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801498763"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.3687,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.77013863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"75","issue":"2","first_page":"524","last_page":"529"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.3959999978542328,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.3959999978542328,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.25099998712539673,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12054","display_name":"Menstrual Health and Disorders","score":0.16410000622272491,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/age-at-menarche","display_name":"age at menarche","score":0.8949999809265137},{"id":"https://openalex.org/keywords/menstrual-irregularities","display_name":"menstrual irregularity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/secondary-amenorrhea","display_name":"secondary amenorrhea","score":0.9660000205039978},{"id":"https://openalex.org/keywords/primary-amenorrhea","display_name":"primary amenorrhea","score":0.8920000195503235},{"id":"https://openalex.org/keywords/oligomenorrhea","display_name":"oligomenorrhea","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polymenorrhea","display_name":"polymenorrhea","score":0.9819999933242798},{"id":"https://openalex.org/keywords/early-onset-diabetes","display_name":"early-onset diabetes","score":0.7300000190734863},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C4258228","wikidata":"https://www.wikidata.org/wiki/Q492514","display_name":"Menarche","level":2,"score":0.8814253807067871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8436682224273682},{"id":"https://openalex.org/C2778058571","wikidata":"https://www.wikidata.org/wiki/Q334655","display_name":"Amenorrhea","level":3,"score":0.7144675254821777},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6874886155128479},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5167223811149597},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5011441707611084},{"id":"https://openalex.org/C2779771394","wikidata":"https://www.wikidata.org/wiki/Q12171","display_name":"Menstruation","level":2,"score":0.4658074975013733},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3829767107963562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3252245783805847},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.295137882232666},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.16227197647094727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000568","descriptor_name":"Amenorrhea","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000568","descriptor_name":"Amenorrhea","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003718","descriptor_name":"Denmark","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008572","descriptor_name":"Menarche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008599","descriptor_name":"Menstruation Disturbances","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008599","descriptor_name":"Menstruation Disturbances","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jc.75.2.524","doi":"https://doi.org/10.1210/jc.75.2.524","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.75.2.524","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jcem.75.2.1639955","doi":"https://doi.org/10.1210/jcem.75.2.1639955","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.75.2.1639955","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:1639955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1639955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1845603411","https://openalex.org/W1880328699","https://openalex.org/W1964364446","https://openalex.org/W1984819973","https://openalex.org/W1987027872","https://openalex.org/W1991454862","https://openalex.org/W2020366807","https://openalex.org/W2032622596","https://openalex.org/W2065482727","https://openalex.org/W2110239433","https://openalex.org/W2162089428","https://openalex.org/W2275098484","https://openalex.org/W2415106155","https://openalex.org/W2417469977","https://openalex.org/W2463479138","https://openalex.org/W2757359455"],"related_works":["https://openalex.org/W2415299462","https://openalex.org/W2312652978","https://openalex.org/W4205209983","https://openalex.org/W2032025935","https://openalex.org/W3035732958","https://openalex.org/W2010831187","https://openalex.org/W2098877506","https://openalex.org/W4231490712","https://openalex.org/W3134811760","https://openalex.org/W1973371401"],"abstract_inverted_index":{"To":[0],"describe":[1],"the":[2,7,35,43,91,100,105,122,128,132,138,194,202,208,231,243],"age":[3,36,72,101,106,232,244],"at":[4,107,233],"menarche":[5,108,234],"and":[6,40,52,56,86,135,156,165,168,176,221],"prevalence":[8,259],"of":[9,16,31,37,45,75,97,102,131,137,143,172,184,201,207,245,260],"menstrual":[10,69,173,261],"disturbances":[11,174,262],"in":[12,42,265],"an":[13],"unselected":[14],"group":[15,74],"women":[17,28,61,77,85,94,134,236,267],"with":[18,95],"insulin-dependent":[19,239],"diabetes":[20,32,98,240],"mellitus":[21,33,241],"compared":[22,254,268],"to":[23,115,255,269],"controls,":[24],"we":[25],"identified":[26],"all":[27,170],"having":[29,237],"debut":[30,96],"before":[34,99,126,192,242],"30":[38],"yr":[39,58,112,247,252],"living":[41],"County":[44],"Funen,":[46],"Denmark":[47],"on":[48],"July":[49],"1,":[50],"1987":[51],"being":[53],"between":[54],"18":[55],"49":[57],"old.":[59],"The":[60,257],"received":[62],"a":[63],"structured":[64],"questionnaire":[65,195],"inquiring":[66],"information":[67],"concerning":[68],"conditions.":[70],"An":[71],"comparable":[73],"nondiabetic":[76,270],"was":[78,109,248],"used":[79],"as":[80],"controls;":[81],"245":[82],"(94%)":[83],"diabetic":[84,133,203,266],"253":[87],"(88%)":[88],"controls":[89,116,139,209],"answered":[90],"questionnaire.":[92],"Among":[93],"10":[103,246],"yr,":[104],"delayed":[110,249],"1":[111,251],"when":[113,253],"comparing":[114],"(P":[117,146,158,179,210,224],"less":[118,147,159,180,211,225],"than":[119,148,160,181,189,212,226],"0.0001).":[120],"During":[121],"past":[123],"6":[124,190],"months":[125,191],"answering":[127,193],"questionnaire,":[129],"8.2%":[130],"2.8%":[136],"had":[140,196],"experienced":[141,198],"episodes":[142],"secondary":[144,185],"amenorrhea":[145,186,218],"0.01).":[149],"Corresponding":[150],"figures":[151,215],"for":[152,162,169,216],"oligomenorrhea":[153],"were":[154,219],"10.6%":[155],"4.8%":[157,206],"0.02),":[161],"polymenorrhea":[163],"7.3%":[164],"5.2%":[166],"(NS),":[167],"types":[171],"21.6%":[175],"10.8%,":[177],"respectively":[178,223],"0.005).":[182],"Episodes":[183],"occurring":[187],"more":[188],"been":[197],"by":[199,250],"10.7%":[200],"population":[204],"vs.":[205],"0.05);":[213],"corresponding":[214],"primary":[217],"4.9%":[220],"1.2%,":[222],"0.05).":[227],"We":[228],"conclude":[229],"that":[230],"among":[235],"developed":[238],"controls.":[256,271],"overall":[258],"is":[263],"increased":[264]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}