{"id":"https://openalex.org/W2048964423","doi":"https://doi.org/10.1016/j.orthres.2003.08.013","title":"The effectiveness of polyethylene versus titanium particles in inducing osteolysis in vivo","display_name":"The effectiveness of polyethylene versus titanium particles in inducing osteolysis in vivo","publication_year":2003,"publication_date":"2003-10-16","ids":{"openalex":"https://openalex.org/W2048964423","doi":"https://doi.org/10.1016/j.orthres.2003.08.013","mag":"2048964423","pmid":"https://pubmed.ncbi.nlm.nih.gov/15013080"},"language":"en","primary_location":{"id":"doi:10.1016/j.orthres.2003.08.013","doi":"https://doi.org/10.1016/j.orthres.2003.08.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.orthres.2003.08.013","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072370851","display_name":"Marius von Knoch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Marius von Knoch","raw_affiliation_strings":["Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA","Orthopaedic University Hospital, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Orthopaedic University Hospital, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090019713","display_name":"Donna E. Jewison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna E. Jewison","raw_affiliation_strings":["Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012576468","display_name":"Jean D. Sibonga","orcid":"https://orcid.org/0009-0001-3529-522X","observed_orcids":["https://orcid.org/0009-0001-3529-522X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean D. Sibonga","raw_affiliation_strings":["Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089967923","display_name":"Christoph M. Sprecher","orcid":"https://orcid.org/0000-0002-5043-1066","observed_orcids":["https://orcid.org/0000-0002-5043-1066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Sprecher","raw_affiliation_strings":["AO Research Institute, Clavadelerstrasse, 7270 Davos, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AO Research Institute, Clavadelerstrasse, 7270 Davos, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003685113","display_name":"B.F. Morrey","orcid":"https://orcid.org/0000-0003-0234-0212","observed_orcids":["https://orcid.org/0000-0003-0234-0212"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard F. Morrey","raw_affiliation_strings":["Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108215977","display_name":"F. L\u00f6er","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franz Loer","raw_affiliation_strings":["Orthopaedic University Hospital, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic University Hospital, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032076466","display_name":"Daniel J. Berry","orcid":"https://orcid.org/0000-0003-1422-0306","observed_orcids":["https://orcid.org/0000-0003-1422-0306"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Berry","raw_affiliation_strings":["Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110238568","display_name":"Sean P. Scully","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean P. Scully","raw_affiliation_strings":["Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110238568"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":3.1957,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.91330547,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"22","issue":"2","first_page":"237","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wear-particle-induced-osteolysis","display_name":"wear particle-induced osteolysis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/polyethylene-particles","display_name":"polyethylene particles","score":0.890999972820282},{"id":"https://openalex.org/keywords/titanium-particles","display_name":"titanium particles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bearing-surface-wear","display_name":"bearing surface wear","score":0.8240000009536743},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9409999847412109},{"id":"https://openalex.org/keywords/osteoclast-recruitment","display_name":"osteoclast recruitment","score":0.9950000047683716},{"id":"https://openalex.org/keywords/periprosthetic-osteolysis","display_name":"periprosthetic osteolysis","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C2781282405","wikidata":"https://www.wikidata.org/wiki/Q2035084","display_name":"Osteolysis","level":2,"score":0.9265975952148438},{"id":"https://openalex.org/C2779751980","wikidata":"https://www.wikidata.org/wiki/Q143429","display_name":"Polyethylene","level":2,"score":0.7046263813972473},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6274347901344299},{"id":"https://openalex.org/C506065880","wikidata":"https://www.wikidata.org/wiki/Q716","display_name":"Titanium","level":2,"score":0.5749003887176514},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.48018065094947815},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.45143136382102966},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.41903167963027954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3809671998023987},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.25805532932281494},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.19673621654510498},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.13876217603683472},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13513270020484924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1070060133934021},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015743","descriptor_name":"Giant Cells, Foreign-Body","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015743","descriptor_name":"Giant Cells, Foreign-Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015743","descriptor_name":"Giant Cells, Foreign-Body","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020959","descriptor_name":"Polyethylene","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.orthres.2003.08.013","doi":"https://doi.org/10.1016/j.orthres.2003.08.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.orthres.2003.08.013","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:15013080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15013080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W59438487","https://openalex.org/W148878557","https://openalex.org/W1831604303","https://openalex.org/W1967000151","https://openalex.org/W1999811942","https://openalex.org/W2009680066","https://openalex.org/W2046786489","https://openalex.org/W2053286399","https://openalex.org/W2057240308","https://openalex.org/W2062901551","https://openalex.org/W2069543291","https://openalex.org/W2072837540","https://openalex.org/W2078844869","https://openalex.org/W2086588124","https://openalex.org/W2087378917","https://openalex.org/W2102837684","https://openalex.org/W2109897832","https://openalex.org/W2146933130","https://openalex.org/W2149359743","https://openalex.org/W2150072015","https://openalex.org/W2160211410","https://openalex.org/W2164068463","https://openalex.org/W2245567567","https://openalex.org/W2395938636","https://openalex.org/W3143184174","https://openalex.org/W4292824376"],"related_works":["https://openalex.org/W1994210098","https://openalex.org/W2144106301","https://openalex.org/W2525257701","https://openalex.org/W2079444126","https://openalex.org/W2074246760","https://openalex.org/W2072233830","https://openalex.org/W2912254500","https://openalex.org/W6940207827","https://openalex.org/W2017004468","https://openalex.org/W2604475440"],"abstract_inverted_index":{"Bearing":[0],"surface":[1,75],"wear":[2,8,25,84,140,161],"and":[3,40,102,145,154],"periprosthetic":[4],"osteolysis":[5,27,86,142],"due":[6],"to":[7,31,41,50,97,127,149],"particles":[9,72,113,125,129],"are":[10],"among":[11],"the":[12,47,63,111,133,151,173],"most":[13,64],"common":[14,65],"reasons":[15],"for":[16],"joint":[17],"replacement":[18],"failure.":[19],"A":[20],"murine":[21,136],"calvarial":[22,81,137],"model":[23,54,82,138,166],"of":[24,45,67,83,110,139,172],"particle-induced":[26,85,141],"has":[28,55],"been":[29],"used":[30],"identify":[32],"different":[33],"biologic":[34],"factors":[35,153],"associated":[36],"with":[37,123],"this":[38],"problem":[39],"test":[42],"nonsurgical":[43],"methods":[44],"modulating":[46],"host":[48,152],"response":[49],"particulate":[51,68],"debris.":[52],"This":[53,165],"utilized":[56],"titanium":[57,112,128,175],"particles,":[58],"however,":[59],"in":[60],"clinical":[61],"practice":[62],"source":[66],"debris":[69,162],"is":[70],"polyethylene":[71,91,115,124,134],"from":[73],"bearing":[74],"wear.":[76],"We":[77,93,131],"now":[78],"report":[79],"a":[80,143],"based":[87,135,176],"on":[88],"commercially":[89],"available":[90],"particles.":[92,116],"found":[94],"that":[95,158],"compared":[96,126],"sham":[98],"surgery":[99],"osteoclast":[100],"recruitment":[101],"bone":[103,118,177],"resorption":[104,119,178],"can":[105,159],"be":[106],"induced":[107],"by":[108],"introduction":[109],"or":[114],"However,":[117],"was":[120],"significantly":[121],"higher":[122],"(p=0.02).":[130],"consider":[132],"reliable":[144],"clinically":[146],"relevant":[147],"tool":[148],"understand":[150],"potential":[155],"pharmacologic":[156],"interventions":[157],"influence":[160],"generated":[163],"osteolysis.":[164],"might":[167],"serve":[168],"as":[169],"an":[170],"extension":[171],"well-established":[174],"model.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
