{"id":"https://openalex.org/W2048914262","doi":"https://doi.org/10.1016/s0031-9384(96)00561-6","title":"The Effect of Centrally Administered CCK-Receptor Antagonists on Food Intake in Rats","display_name":"The Effect of Centrally Administered CCK-Receptor Antagonists on Food Intake in Rats","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W2048914262","doi":"https://doi.org/10.1016/s0031-9384(96)00561-6","mag":"2048914262","pmid":"https://pubmed.ncbi.nlm.nih.gov/9177553"},"language":"en","primary_location":{"id":"doi:10.1016/s0031-9384(96)00561-6","doi":"https://doi.org/10.1016/s0031-9384(96)00561-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0031-9384(96)00561-6","pdf_url":null,"source":{"id":"https://openalex.org/S167407068","display_name":"Physiology & Behavior","issn_l":"0031-9384","issn":["0031-9384","1873-507X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology &amp; Behavior","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0031-9384(96)00561-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111610177","display_name":"Michael J. Curcio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Curcio","raw_affiliation_strings":["Department of Psychiatry, Cornell University Medical College and E. W. Bourne Behavioral Research Laboratory, The New York Hospital-Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605 USA","Department of Psychiatry, Cornell University Medical College, The New York Hospital-Cornell Medical Center, White Plains 10605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Cornell University Medical College and E. W. Bourne Behavioral Research Laboratory, The New York Hospital-Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605 USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Psychiatry, Cornell University Medical College, The New York Hospital-Cornell Medical Center, White Plains 10605, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110210635","display_name":"James Gibbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Gibbs","raw_affiliation_strings":["Department of Psychiatry, Cornell University Medical College and E. W. Bourne Behavioral Research Laboratory, The New York Hospital-Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Cornell University Medical College and E. W. Bourne Behavioral Research Laboratory, The New York Hospital-Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605 USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111650435","display_name":"Gerard P. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard P Smith","raw_affiliation_strings":["Department of Psychiatry, Cornell University Medical College and E. W. Bourne Behavioral Research Laboratory, The New York Hospital-Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Cornell University Medical College and E. W. Bourne Behavioral Research Laboratory, The New York Hospital-Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605 USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.0392,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.76668786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"61","issue":"6","first_page":"823","last_page":"827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cck-receptors","display_name":"CCK receptors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cck-a-receptor","display_name":"CCK-A receptor","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cck-b-receptor","display_name":"CCK-B receptor","score":1.0},{"id":"https://openalex.org/keywords/proglumide","display_name":"proglumide","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lorglumide","display_name":"lorglumide","score":0.9769999980926514},{"id":"https://openalex.org/keywords/devazepide","display_name":"devazepide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cck-8","display_name":"CCK-8","score":0.8659999966621399},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.8320000171661377},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.9419999718666077},{"id":"https://openalex.org/keywords/meal-size","display_name":"meal size","score":0.8389999866485596},{"id":"https://openalex.org/keywords/central-administration","display_name":"centralized management","score":0.7310000061988831},{"id":"https://openalex.org/keywords/lateral-ventricle","display_name":"lateral ventricle","score":0.871999979019165},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.6000354886054993},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49539244174957275},{"id":"https://openalex.org/C2777593968","wikidata":"https://www.wikidata.org/wiki/Q60315441","display_name":"Cholecystokinin","level":3,"score":0.4877060353755951},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.47914713621139526},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46691182255744934},{"id":"https://openalex.org/C3017650416","wikidata":"https://www.wikidata.org/wiki/Q3281331","display_name":"Feeding behavior","level":2,"score":0.4472613036632538},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43330082297325134},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33760690689086914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3306170403957367}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001570","descriptor_name":"Benzodiazepinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006727","descriptor_name":"Hormone Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011377","descriptor_name":"Proglumide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011949","descriptor_name":"Receptors, Cholecystokinin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012844","descriptor_name":"Sincalide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020109","descriptor_name":"Devazepide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0031-9384(96)00561-6","doi":"https://doi.org/10.1016/s0031-9384(96)00561-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0031-9384(96)00561-6","pdf_url":null,"source":{"id":"https://openalex.org/S167407068","display_name":"Physiology & Behavior","issn_l":"0031-9384","issn":["0031-9384","1873-507X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology &amp; Behavior","raw_type":"journal-article"},{"id":"pmid:9177553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9177553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology & behavior","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0031-9384(96)00561-6","doi":"https://doi.org/10.1016/s0031-9384(96)00561-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0031-9384(96)00561-6","pdf_url":null,"source":{"id":"https://openalex.org/S167407068","display_name":"Physiology & Behavior","issn_l":"0031-9384","issn":["0031-9384","1873-507X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology &amp; Behavior","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1639443059","display_name":"PHYSIOLOGICAL PSYCHOLOGY OF MOTIVATED BEHAVIOR","funder_award_id":"K05MH000149","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3006913231","display_name":null,"funder_award_id":"MH00149","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4037217449","display_name":"SATIETY EFFECT OF CHOLECYSTOKININ","funder_award_id":"R01MH040010","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W238463063","https://openalex.org/W1842060488","https://openalex.org/W1966679920","https://openalex.org/W1971699667","https://openalex.org/W1971797445","https://openalex.org/W1979100850","https://openalex.org/W1982594208","https://openalex.org/W1986832734","https://openalex.org/W1988646125","https://openalex.org/W1991714764","https://openalex.org/W1994091958","https://openalex.org/W1998503390","https://openalex.org/W1999559574","https://openalex.org/W2009049908","https://openalex.org/W2015046754","https://openalex.org/W2026976274","https://openalex.org/W2030203909","https://openalex.org/W2042505278","https://openalex.org/W2077449996","https://openalex.org/W2093053031","https://openalex.org/W2126681559","https://openalex.org/W2131517642","https://openalex.org/W2150325253","https://openalex.org/W2155805338","https://openalex.org/W2176139734","https://openalex.org/W2290579942","https://openalex.org/W2412677816","https://openalex.org/W2414434947","https://openalex.org/W4229585371","https://openalex.org/W4238882187","https://openalex.org/W4388296265","https://openalex.org/W4388296373","https://openalex.org/W4388296402","https://openalex.org/W4388316299","https://openalex.org/W6679211595"],"related_works":["https://openalex.org/W2414434947","https://openalex.org/W1963725942","https://openalex.org/W2066934369","https://openalex.org/W1968535072","https://openalex.org/W2099320902","https://openalex.org/W2167562456","https://openalex.org/W1993866430","https://openalex.org/W2292233241","https://openalex.org/W1998837291","https://openalex.org/W2035592824"],"abstract_inverted_index":{"Cholecystokinin":[0],"(CCK)":[1],"receptors":[2],"are":[3,15],"classified":[4],"as":[5],"two":[6],"subtypes,":[7],"designated":[8],"CCK(A)":[9],"and":[10,12,19,35,84,99,136,148,158,193,210,235,240],"CCK(B),":[11],"both":[13],"subtypes":[14],"found":[16],"in":[17,49,64,131,232,260],"brain":[18,234],"peripheral":[20,53,120],"tissues":[21],"of":[22,55,68,89,107,122,141,165,200,208,220,248,256],"rats.":[23],"CCK-8":[24,92,123,259],"has":[25,77],"been":[26,78],"shown":[27,79],"to":[28,31,51,80,97,118],"act":[29],"peripherally":[30,90,166,221,257],"reduce":[32],"meal":[33,134,249],"size,":[34],"this":[36],"satiating":[37,87,139,254],"action":[38,54],"can":[39],"be":[40,62],"blocked":[41],"by":[42,230],"CCK(A)-receptor":[43,145],"antagonists.":[44],"Recent":[45],"evidence":[46],"suggests":[47],"that,":[48],"addition":[50],"the":[52,86,114,138,163,181,197,218,233,246,253],"CCK,":[56],"central":[57,238],"CCK":[58,201,228],"mechanisms":[59],"may":[60],"also":[61],"involved":[63],"satiety.":[65],"Central":[66],"administration":[67],"proglumide,":[69],"a":[70,119,206],"mixed":[71],"CCK-receptor":[72,111],"antagonist":[73],"(CCK(A)":[74],">":[75],"CCK(B))":[76],"increase":[81,130,152,188,214],"food":[82],"intake":[83,135,153,175,189,215],"block":[85,217],"effect":[88,140,164,199,219,255],"administered":[91,167,222,258],"(15).":[93],"In":[94],"an":[95,129],"attempt":[96],"replicate":[98],"extend":[100],"these":[101],"results,":[102],"rats":[103,261],"were":[104],"given":[105,156,191],"injections":[106],"proglumide":[108,127],"or":[109,124,216,251],"selective":[110,144,170],"antagonists":[112],"into":[113],"lateral":[115],"ventricle":[116],"prior":[117],"injection":[121],"saline.":[125],"Only":[126],"stimulated":[128],"30-min":[132],"test":[133],"attenuated":[137],"CCK-8.":[142,168,223],"Two":[143],"antagonists,":[146],"lorglumide":[147],"devazepide,":[149],"did":[150,160,186,194,212],"not":[151,161,187,195,213,243],"significantly":[154],"when":[155,190],"alone,":[157],"they":[159],"attenuate":[162,196],"The":[169,183],"CCK(B)-receptor":[171],"antagonist,":[172],"L365,260,":[173],"reduced":[174],"at":[176],"all":[177],"doses":[178],"tested":[179],"except":[180],"lowest.":[182],"lowest":[184],"dose":[185],"alone":[192],"inhibitory":[198],"on":[202,237],"test-meal":[203],"intake.":[204],"Finally,":[205],"combination":[207],"devazepide":[209],"L365,260":[211],"These":[224],"results":[225],"suggest":[226],"that":[227],"released":[229],"neurons":[231],"acting":[236],"CCK(A)-":[239],"CCK(B)-receptors":[241],"is":[242],"necessary":[244],"for":[245,252],"control":[247],"size":[250],"under":[262],"our":[263],"experimental":[264],"conditions.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
