{"id":"https://openalex.org/W204890274","doi":null,"title":"iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1.","display_name":"iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1.","publication_year":1997,"publication_date":"1997-07-15","ids":{"openalex":"https://openalex.org/W204890274","mag":"204890274","pmid":"https://pubmed.ncbi.nlm.nih.gov/9244230"},"language":"en","primary_location":{"id":"pmid:9244230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9244230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022390052","display_name":"Kurt Bachmaier","orcid":"https://orcid.org/0000-0002-0299-2707","observed_orcids":["https://orcid.org/0000-0002-0299-2707"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"K Bachmaier","raw_affiliation_strings":["Amgen Institute, Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Institute, Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110251004","display_name":"Nikolaus Neu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Neu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002231254","display_name":"C Pummerer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Pummerer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113576672","display_name":"G S Duncan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G S Duncan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000800493","display_name":"Tak W. Mak","orcid":"https://orcid.org/0000-0001-6766-861X","observed_orcids":["https://orcid.org/0000-0001-6766-861X","https://orcid.org/0000-0002-0459-4112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T W Mak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054251357","display_name":"T. Matsuyama","orcid":"https://orcid.org/0000-0003-1831-4094","observed_orcids":["https://orcid.org/0000-0003-1831-4094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Matsuyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059310975","display_name":"Josef Martin Penninger","orcid":"https://orcid.org/0000-0002-8194-3777","observed_orcids":["https://orcid.org/0000-0002-8194-3777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Penninger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.5154,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.96901893,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"96","issue":"2","first_page":"585","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/autoimmune-myocarditis","display_name":"autoimmune myocarditis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/myocarditis","display_name":"myocarditis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9179999828338623},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2779385521","wikidata":"https://www.wikidata.org/wiki/Q412383","display_name":"Nitrotyrosine","level":4,"score":0.8210667967796326},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.7746067047119141},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6737580895423889},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6456447839736938},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4816685914993286},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.47352004051208496},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4713280498981476},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.42594847083091736},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4118940234184265},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.3906937837600708},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32931631803512573},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3181331753730774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2618855834007263},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.20275887846946716}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D050856","descriptor_name":"Interferon Regulatory Factor-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9244230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9244230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"mag:204890274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9244230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2081529528","https://openalex.org/W2138552407","https://openalex.org/W1981318602","https://openalex.org/W4361273573","https://openalex.org/W2933157969","https://openalex.org/W2148029579","https://openalex.org/W3035948828","https://openalex.org/W3099371178","https://openalex.org/W3006016514","https://openalex.org/W1997157483"],"abstract_inverted_index":{"BACKGROUND:":[0],"Production":[1],"of":[2,15,28,70,80,105,178,250],"NO":[3,6,64,107,195,218],"by":[4,53,103],"inducible":[5],"synthase":[7],"(iNOS)":[8],"has":[9],"been":[10],"implicated":[11],"in":[12,25,67,91,95,111,117,163,188,197,204,220,227,243],"the":[13,26,58,68,77,106,139,146,164,186,238,248],"pathology":[14],"spontaneous":[16],"and":[17,21,60,63,94,121,160,173,194,199,217,247,253],"antigen-induced":[18],"autoimmune":[19,40,71,223],"diseases,":[20],"iNOS":[22,55,62,87,119,158,192,215,241],"is":[23,34,51],"expressed":[24],"myocardium":[27],"patients":[29],"with":[30],"heart":[31,41,49,59,99,141,165,208,245,254],"failure.":[32,255],"It":[33],"not":[35],"clear":[36],"whether":[37,61],"inflammatory":[38,92,112,207,244],"murine":[39,78,206],"disease,":[42,50],"an":[43],"experimental":[44,205],"model":[45,79],"for":[46,145],"human":[47],"postviral":[48],"characterized":[52],"increased":[54],"expression":[56,88,120,159,193,216,242],"within":[57],"are":[65,202],"essential":[66],"pathogenesis":[69],"myocarditis.":[72],"METHODS":[73],"AND":[74],"RESULTS:":[75],"In":[76],"cardiac":[81,168],"myosin-induced":[82,169],"myocarditis,":[83],"we":[84],"demonstrate":[85],"that":[86,191],"was":[89,101,132],"elicited":[90,203],"macrophages":[93,113,198],"distinct":[96,200],"cardiomyocytes.":[97,118],"Autoimmune":[98],"disease":[100,246],"accompanied":[102],"formation":[104,123,137,162],"reaction":[108],"product":[109],"nitrotyrosine":[110,122,136,161],"as":[114,116],"well":[115],"were":[124],"strictly":[125],"dependent":[126],"on":[127],"myocardial":[128],"inflammation.":[129],"Focal":[130],"myocarditis":[131,170,224],"sufficient":[133],"to":[134,156,176,236],"induce":[135,157],"throughout":[138],"whole":[140],"muscle.":[142],"Mice":[143],"defective":[144],"interferon":[147],"regulatory":[148],"transcription":[149,211],"factor-1":[150],"(IRF-1(-/-))":[151],"after":[152],"gene":[153],"targeting":[154],"failed":[155],"but":[166],"developed":[167],"at":[171],"prevalence":[172],"severity":[174],"similar":[175],"those":[177],"heterozygous":[179],"littermates":[180],"(IRF-1(+/-)).":[181],"CONCLUSIONS:":[182],"These":[183],"data":[184],"provide":[185],"first":[187],"vivo":[189],"evidence":[190],"synthesis":[196,219],"cardiomyocytes":[201],"disease.":[209,221],"The":[210],"factor":[212],"IRF-1":[213],"controls":[214],"Because":[222],"can":[225],"develop":[226],"animals":[228],"lacking":[229],"IRF-1,":[230],"these":[231],"mice":[232],"will":[233],"be":[234],"useful":[235],"elucidate":[237],"link":[239],"between":[240],"development":[249],"dilated":[251],"cardiomyopathy":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
