{"id":"https://openalex.org/W2048879110","doi":"https://doi.org/10.1371/journal.pone.0042645","title":"The Colitis-Associated Transcriptional Profile of Commensal Bacteroides thetaiotaomicron Enhances Adaptive Immune Responses to a Bacterial Antigen","display_name":"The Colitis-Associated Transcriptional Profile of Commensal Bacteroides thetaiotaomicron Enhances Adaptive Immune Responses to a Bacterial Antigen","publication_year":2012,"publication_date":"2012-08-03","ids":{"openalex":"https://openalex.org/W2048879110","doi":"https://doi.org/10.1371/journal.pone.0042645","mag":"2048879110","pmid":"https://pubmed.ncbi.nlm.nih.gov/22880065","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3411805"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0042645","doi":"https://doi.org/10.1371/journal.pone.0042645","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0042645","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042645&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042645&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111238972","display_name":"Jonathan J. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan J. Hansen","raw_affiliation_strings":["Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. jjhansen@med.unc.edu","Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. jjhansen@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Huang","raw_affiliation_strings":["Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103232024","display_name":"Daniel A. Peterson","orcid":"https://orcid.org/0000-0001-9649-3580","observed_orcids":["https://orcid.org/0000-0001-9649-3580"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Peterson","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042397822","display_name":"Laura E. Goeser","orcid":"https://orcid.org/0000-0003-3636-292X","observed_orcids":["https://orcid.org/0000-0003-3636-292X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Goeser","raw_affiliation_strings":["Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112646307","display_name":"Ting-Jia Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting-Jia Fan","raw_affiliation_strings":["Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042231260","display_name":"Eugene B. Chang","orcid":"https://orcid.org/0000-0001-5972-8248","observed_orcids":["https://orcid.org/0000-0001-5972-8248"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene B. Chang","raw_affiliation_strings":["Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049586381","display_name":"Ryan Balfour Sartor","orcid":"https://orcid.org/0000-0002-7820-632X","observed_orcids":["https://orcid.org/0000-0002-7820-632X","https://orcid.org/0000-0002-9621-0824"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Balfour Sartor","raw_affiliation_strings":["Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111238972"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.7888,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.84336574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"8","first_page":"e42645","last_page":"e42645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.26809999346733093,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacteroides-thetaiotaomicron","display_name":"Bacteroides thetaiotaomicron","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8880000114440918},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hla-b27-transgenic-rats","display_name":"HLA-B27 transgenic rats","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gut-commensal-bacteria","display_name":"gut commensal bacteria","score":0.6710000038146973},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.6330000162124634},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2908934157","wikidata":"https://www.wikidata.org/wiki/Q798597","display_name":"Bacteroides thetaiotaomicron","level":4,"score":0.7416869401931763},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7181528806686401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6648017168045044},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.652295708656311},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.647742509841919},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6368128657341003},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5631095767021179},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.529360830783844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4850453734397888},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.47350603342056274},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4682883620262146},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4191988408565521},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38863593339920044},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.38077312707901},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31589198112487793},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3066529631614685},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21794500946998596},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20829811692237854},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.17569950222969055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13588932156562805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10408750176429749}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015796","descriptor_name":"HLA-B27 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050296","descriptor_name":"Microbial Viability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055647","descriptor_name":"Rats, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0042645","doi":"https://doi.org/10.1371/journal.pone.0042645","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0042645","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042645&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3411805","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3411805","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22880065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22880065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:qn59qc34h","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/qy7x-mr77","pdf_url":"https://doi.org/10.17615/qy7x-mr77","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PloS One, 7(8)","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.946.2597","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.946.2597","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3411805%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6208a66cd4ca4c94be696925670e5763","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6208a66cd4ca4c94be696925670e5763","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 8, p e42645 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/121825","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_Colitis_Associated_Transcriptional_Profile_of_Commensal_Bacteroides_thetaiotaomicron_Enhances_Adaptive_Immune_Responses_to_a_Bacterial_Antigen/121825","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.17615/qy7x-mr77","doi":"https://doi.org/10.17615/qy7x-mr77","is_oa":true,"landing_page_url":"https://doi.org/10.17615/qy7x-mr77","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0042645","doi":"https://doi.org/10.1371/journal.pone.0042645","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0042645","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042645&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1715857622","display_name":null,"funder_award_id":"P30 DK34987","funder_id":"https://openalex.org/F4320338389","funder_display_name":"Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill"},{"id":"https://openalex.org/G3097878166","display_name":null,"funder_award_id":"P40 RR18803","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3329188363","display_name":null,"funder_award_id":"DK34987","funder_id":"https://openalex.org/F4320338389","funder_display_name":"Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill"},{"id":"https://openalex.org/G4055263915","display_name":"Bacterial Stress Responses to Intestinal Inflammation","funder_award_id":"K08DK087896","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7205445978","display_name":null,"funder_award_id":"DK42086","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7294357767","display_name":null,"funder_award_id":"DK42086","funder_id":"https://openalex.org/F4320309626","funder_display_name":"University of Chicago"},{"id":"https://openalex.org/G7467722993","display_name":"Colitis Induced by immune responses to luminal bacteria-mouse","funder_award_id":"R01DK053347","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000012814","display_name":null,"funder_award_id":"DK42086","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000083219","display_name":null,"funder_award_id":"DK-34987","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000863902","display_name":"Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)","funder_award_id":"P30DK042086","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868127","display_name":"Center for Gastrointestinal Biology and Disease","funder_award_id":"P30DK034987","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320338389","display_name":"Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2048879110.pdf","grobid_xml":"https://content.openalex.org/works/W2048879110.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1642457845","https://openalex.org/W1670573097","https://openalex.org/W1708068686","https://openalex.org/W1963890672","https://openalex.org/W1965792653","https://openalex.org/W1970279206","https://openalex.org/W1973668364","https://openalex.org/W1985609109","https://openalex.org/W1987660324","https://openalex.org/W1991723267","https://openalex.org/W2002170378","https://openalex.org/W2002477604","https://openalex.org/W2003525072","https://openalex.org/W2008764825","https://openalex.org/W2039625460","https://openalex.org/W2040113209","https://openalex.org/W2042045767","https://openalex.org/W2044894353","https://openalex.org/W2044977356","https://openalex.org/W2047059509","https://openalex.org/W2057759034","https://openalex.org/W2059101019","https://openalex.org/W2060144150","https://openalex.org/W2060144673","https://openalex.org/W2063688039","https://openalex.org/W2064318892","https://openalex.org/W2084512022","https://openalex.org/W2097875133","https://openalex.org/W2103847109","https://openalex.org/W2105190780","https://openalex.org/W2107879555","https://openalex.org/W2108155566","https://openalex.org/W2112970127","https://openalex.org/W2130410032","https://openalex.org/W2134617060","https://openalex.org/W2141125135","https://openalex.org/W2146279598","https://openalex.org/W2153386849","https://openalex.org/W2153905079","https://openalex.org/W2156028799","https://openalex.org/W2157795344","https://openalex.org/W2165407078","https://openalex.org/W4244000631","https://openalex.org/W4294107304","https://openalex.org/W4300541889"],"related_works":["https://openalex.org/W877972657","https://openalex.org/W872641795","https://openalex.org/W1647337402","https://openalex.org/W1805438519","https://openalex.org/W1973304227","https://openalex.org/W1978631024","https://openalex.org/W2150183744","https://openalex.org/W1981951847","https://openalex.org/W2911801045","https://openalex.org/W2137781541"],"abstract_inverted_index":{"BACKGROUND:":[0],"Inflammatory":[1],"bowel":[2],"diseases":[3],"(IBD)":[4],"may":[5,271,282],"be":[6],"caused":[7],"in":[8,56,59,173,182,187,194,210,228,244,252,264],"part":[9],"by":[10,94],"aberrant":[11],"immune":[12,140,242,274],"responses":[13,141,243],"to":[14,73,137,142,284],"commensal":[15,23,42],"intestinal":[16],"microbes":[17,71],"including":[18],"the":[19,51,211,279,285],"well-characterized":[20],"anaerobic":[21],"gut":[22,41,70],"Bacteroides":[24],"thetaiotaomicron":[25],"(B.":[26],"theta).":[27],"Healthy,":[28],"germ-free":[29,159],"HLA-B27":[30,253],"transgenic":[31],"(Tg)":[32],"rats":[33,47,61,80,199,233],"develop":[34],"chronic":[35,162],"colitis":[36,201,251],"when":[37],"colonized":[38],"with":[39,83,200,259],"complex":[40],"bacteria":[43],"whereas":[44],"non-transgenic":[45],"(nTg)":[46],"remain":[48],"disease-free.":[49],"However,":[50],"role":[52],"of":[53,87,106,124,166,219,261,278,287],"B.":[54,88,107,146,150,168,195,229,248],"theta":[55,108,147,151,169,196,230,249],"causing":[57],"disease":[58],"Tg":[60,77,153,174,198,232,245,254],"is":[62,65,257],"unknown":[63],"nor":[64],"much":[66],"known":[67],"about":[68],"how":[69],"respond":[72],"host":[74,273],"inflammation.":[75],"METHODS:":[76],"and":[78,97,117,126,190,234,266],"nTg":[79,157,176],"were":[81,135,170,192,206,225],"monoassociated":[82,152],"a":[84,143,236],"human":[85],"isolate":[86],"theta.":[89],"Colonic":[90],"inflammation":[91],"was":[92,112],"assessed":[93],"histologic":[95],"scoring":[96],"tissue":[98],"pro-inflammatory":[99],"cytokine":[100],"measurement.":[101],"Whole":[102],"genome":[103],"transcriptional":[104],"profiling":[105],"recovered":[109],"from":[110,197,231],"ceca":[111],"performed":[113],"using":[114,120],"custom":[115],"GeneChips":[116],"data":[118],"analyzed":[119],"dChip,":[121],"Significance":[122],"Analysis":[123,130],"Microarrays,":[125],"Gene":[127,212],"Set":[128],"Enrichment":[129],"(GSEA)":[131],"software.":[132],"Western":[133],"Blots":[134],"used":[136],"determine":[138],"adaptive":[139,241],"differentially":[144],"expressed":[145],"gene.":[148],"RESULTS:":[149],"rats,":[154,255],"but":[155],"not":[156],"or":[158],"controls,":[160],"developed":[161],"colitis.":[163],"Transcriptional":[164],"profiles":[165],"cecal":[167],"significantly":[171,226],"different":[172],"vs.":[175],"rats.":[177,246],"GSEA":[178],"revealed":[179],"that":[180,239,270],"genes":[181,209,263],"KEGG":[183],"canonical":[184],"pathways":[185,269],"involved":[186],"bacterial":[188,204,262],"growth":[189],"metabolism":[191],"downregulated":[193],"though":[202],"luminal":[203],"concentrations":[205],"unaffected.":[207],"Bacterial":[208],"Ontology":[213],"molecular":[214],"function":[215],"\"receptor":[216],"activity\",":[217],"most":[218],"which":[220,256],"encode":[221],"nutrient":[222,267],"binding":[223,268],"proteins,":[224],"upregulated":[227],"include":[235],"SusC":[237],"homolog":[238],"induces":[240,250],"CONCLUSIONS:":[247],"associated":[258],"regulation":[260],"metabolic":[265],"affect":[272],"responses.":[275],"These":[276],"studies":[277],"host-microbial":[280],"dialogue":[281],"lead":[283],"identification":[286],"novel":[288],"microbial":[289],"targets":[290],"for":[291],"IBD":[292],"therapies.":[293]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}