{"id":"https://openalex.org/W2048848243","doi":"https://doi.org/10.1111/j.1525-1470.2008.00800.x","title":"5% 5\u2010Fluorouracil Cream for Treatment of Verruca Vulgaris in Children","display_name":"5% 5\u2010Fluorouracil Cream for Treatment of Verruca Vulgaris in Children","publication_year":2009,"publication_date":"2009-03-11","ids":{"openalex":"https://openalex.org/W2048848243","doi":"https://doi.org/10.1111/j.1525-1470.2008.00800.x","mag":"2048848243","pmid":"https://pubmed.ncbi.nlm.nih.gov/19706088"},"language":"en","primary_location":{"id":"doi:10.1111/j.1525-1470.2008.00800.x","doi":"https://doi.org/10.1111/j.1525-1470.2008.00800.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-1470.2008.00800.x","pdf_url":null,"source":{"id":"https://openalex.org/S3992287","display_name":"Pediatric Dermatology","issn_l":"0736-8046","issn":["0736-8046","1525-1470"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007018788","display_name":"Julie Akiko Gladsjo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Akiko Gladsjo","raw_affiliation_strings":["University of California, San Diego, California, USA","University of California, San Diego, #N#California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"University of California, San Diego, #N#California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051850207","display_name":"Alessandra B Ali\u00f3 Saenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandra B. Ali\u00f3 S\u00e1enz","raw_affiliation_strings":["Rady Children\u2019s Hospital and Health Center, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rady Children\u2019s Hospital and Health Center, San Diego, California","institution_ids":["https://openalex.org/I4210087384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080166571","display_name":"James N. Bergman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James Bergman","raw_affiliation_strings":["Division of Dermatology, University of British Columbia, Vancouver, British Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Dermatology, University of British Columbia, Vancouver, British Columbia","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018239511","display_name":"Greg Kricorian","orcid":"https://orcid.org/0000-0002-9419-9836","observed_orcids":["https://orcid.org/0000-0002-9419-9836"]},"institutions":[{"id":"https://openalex.org/I4210097125","display_name":"Bausch Health (United States)","ror":"https://ror.org/00zdkew04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097125","https://openalex.org/I4210108068"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Kricorian","raw_affiliation_strings":["Valeant Pharmaceuticals International, Costa Mesa, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Valeant Pharmaceuticals International, Costa Mesa, California","institution_ids":["https://openalex.org/I4210097125"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113575048","display_name":"Bari B. Cunningham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bari B. Cunningham","raw_affiliation_strings":["Comprehensive Dermatology Group, Encinitas, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Dermatology Group, Encinitas, California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5113575048"],"corresponding_institution_ids":[],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":3.3279,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.91481726,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"26","issue":"3","first_page":"279","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.1703999936580658,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12116","display_name":"Dermatological diseases and infestations","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9340000152587891},{"id":"https://openalex.org/keywords/topical-chemotherapy","display_name":"topical chemotherapy","score":0.6700000166893005},{"id":"https://openalex.org/keywords/common-warts","display_name":"common warts","score":0.7630000114440918},{"id":"https://openalex.org/keywords/verruca-vulgaris","display_name":"verruca vulgaris","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hand-warts","display_name":"hand warts","score":0.8289999961853027},{"id":"https://openalex.org/keywords/wart-recurrence","display_name":"wart recurrence","score":0.7950000166893005},{"id":"https://openalex.org/keywords/treatment-tolerability","display_name":"treatment tolerability","score":0.7429999709129333},{"id":"https://openalex.org/keywords/occlusion-therapy","display_name":"occlusion therapy","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9539731740951538},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.8654302358627319},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8646535277366638},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.47170400619506836},{"id":"https://openalex.org/C2909003316","wikidata":"https://www.wikidata.org/wiki/Q101971","display_name":"Verruca Vulgaris","level":2,"score":0.4261839985847473},{"id":"https://openalex.org/C2779923671","wikidata":"https://www.wikidata.org/wiki/Q199602","display_name":"Itching","level":2,"score":0.41954925656318665},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3920031189918518},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38241010904312134},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.33113157749176025},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3100232481956482}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000963","descriptor_name":"Antimetabolites","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006229","descriptor_name":"Hand Dermatoses","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009824","descriptor_name":"Ointments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014860","descriptor_name":"Warts","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1525-1470.2008.00800.x","doi":"https://doi.org/10.1111/j.1525-1470.2008.00800.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-1470.2008.00800.x","pdf_url":null,"source":{"id":"https://openalex.org/S3992287","display_name":"Pediatric Dermatology","issn_l":"0736-8046","issn":["0736-8046","1525-1470"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Dermatology","raw_type":"journal-article"},{"id":"pmid:19706088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19706088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1507760891","https://openalex.org/W1584211240","https://openalex.org/W1864932294","https://openalex.org/W1973121679","https://openalex.org/W1977308926","https://openalex.org/W1978336933","https://openalex.org/W1990865349","https://openalex.org/W1993379681","https://openalex.org/W2004364535","https://openalex.org/W2017564324","https://openalex.org/W2026834712","https://openalex.org/W2040053844","https://openalex.org/W2047494752","https://openalex.org/W2049468550","https://openalex.org/W2075618409","https://openalex.org/W2084606377","https://openalex.org/W2100406698","https://openalex.org/W2100502747","https://openalex.org/W2107605789","https://openalex.org/W2128869982","https://openalex.org/W2129684203","https://openalex.org/W2135282782","https://openalex.org/W2163367279","https://openalex.org/W4211188924"],"related_works":["https://openalex.org/W3184226279","https://openalex.org/W4412788268","https://openalex.org/W2947016733","https://openalex.org/W2237032189","https://openalex.org/W2947292690","https://openalex.org/W2075618409","https://openalex.org/W3110231028","https://openalex.org/W2074188160","https://openalex.org/W29562800","https://openalex.org/W2069576817"],"abstract_inverted_index":{"Warts":[0],"are":[1,15],"a":[2,185],"common":[3,50],"pediatric":[4,60],"skin":[5],"disease.":[6],"Most":[7],"treatments":[8],"show":[9],"only":[10],"modest":[11],"benefit,":[12],"and":[13,26,30,41,92,101,103,111,131,155,188],"some":[14],"poorly":[16],"tolerated":[17],"because":[18],"of":[19,43,49,89,122,129,133,138,167,174],"pain.":[20],"5-fluorouracil":[21,46,73,183],"interferes":[22],"with":[23,59],"deoxyribonucleic":[24],"acid":[25,28],"ribonucleic":[27],"synthesis,":[29],"is":[31,184],"used":[32],"to":[33],"treat":[34],"genital":[35],"warts":[36,51,70,124,192],"in":[37,54,193],"adults.":[38],"Efficacy,":[39],"safety,":[40],"tolerability":[42],"topical":[44],"5%":[45,72,182],"for":[47,85,191],"treatment":[48,90,99,118,190],"were":[52,115,158],"examined":[53],"an":[55],"open-label":[56],"pilot":[57],"study":[58],"patients.":[61],"Thirty-nine":[62],"children":[63],"who":[64],"have":[65],"at":[66,97,117,139],"least":[67,140],"two":[68],"hand":[69],"applied":[71],"cream":[74],"(Efudex,":[75],"Valeant":[76],"Pharmaceuticals":[77],"International)":[78],"once":[79,149],"or":[80,150],"twice":[81,151],"daily,":[82],"under":[83],"occlusion":[84],"6":[86,127,170],"weeks.":[87],"Assessment":[88],"response":[91,144],"side":[93],"effects":[94],"was":[95],"performed":[96],"baseline,":[98],"completion,":[100],"3-":[102],"6-month":[104],"follow-ups.":[105],"Hematology":[106],"measures,":[107],"liver":[108],"function":[109],"tests,":[110],"medication":[112],"blood":[113,165],"levels":[114,166],"reassessed":[116],"completion.":[119],"Eighty-eight":[120],"percent":[121],"treated":[123],"improved":[125],"after":[126],"weeks":[128],"treatment,":[130],"41%":[132],"subjects":[134],"had":[135,162,177],"complete":[136,175],"resolution":[137],"one":[141],"wart.":[142],"Treatment":[143],"did":[145],"not":[146],"differ":[147],"between":[148],"daily":[152],"applications.":[153],"Tolerability":[154],"patient":[156],"satisfaction":[157],"excellent.":[159],"No":[160],"subject":[161],"clinically":[163],"significant":[164],"5-fluorouracil.":[168],"At":[169],"month":[171],"follow-up,":[172],"87%":[173],"responders":[176],"no":[178],"wart":[179],"recurrence.":[180],"Topical":[181],"safe,":[186],"effective,":[187],"well-tolerated":[189],"children.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
