{"id":"https://openalex.org/W2048845786","doi":"https://doi.org/10.3892/ijmm.13.6.849","title":"Plasma osteoprotegerin as a biochemical marker for vascular dementia and Alzheimer's disease","display_name":"Plasma osteoprotegerin as a biochemical marker for vascular dementia and Alzheimer's disease","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2048845786","doi":"https://doi.org/10.3892/ijmm.13.6.849","mag":"2048845786","pmid":"https://pubmed.ncbi.nlm.nih.gov/15138623"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.13.6.849","doi":"https://doi.org/10.3892/ijmm.13.6.849","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.13.6.849","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087722833","display_name":"Enzo Emanuele","orcid":"https://orcid.org/0000-0003-3908-0290","observed_orcids":["https://orcid.org/0000-0003-3908-0290","https://orcid.org/0000-0002-4356-9366"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enzo Emanuele","raw_affiliation_strings":["Molecular Medicine Laboratory, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Laboratory, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054691090","display_name":"Emmanouil Peros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emmanouil Peros","raw_affiliation_strings":["University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009637971","display_name":"Giuseppe Antonio Scioli","orcid":"https://orcid.org/0009-0008-3455-4622","observed_orcids":["https://orcid.org/0009-0008-3455-4622"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Scioli","raw_affiliation_strings":["University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049217502","display_name":"Angela D\u2019Angelo","orcid":"https://orcid.org/0000-0003-3008-9264","observed_orcids":["https://orcid.org/0000-0003-3008-9264"]},"institutions":[{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela D'Angelo","raw_affiliation_strings":["IRCCS Fondazione Policlinico San Matteo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Fondazione Policlinico San Matteo","institution_ids":["https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103945501","display_name":"Carlo Olivieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Olivieri","raw_affiliation_strings":["University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060492514","display_name":"Lorenza Montagna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenza Montagna","raw_affiliation_strings":["University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111554000","display_name":"Diego Geroldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego Geroldi","raw_affiliation_strings":["University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2431,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.79355679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"6","first_page":"849","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":1.0},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.902999997138977},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.48399999737739563},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.6179999709129333},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6579999923706055},{"id":"https://openalex.org/keywords/italian-population","display_name":"Italian population","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.7693725824356079},{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.7474435567855835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7069698572158813},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.703628420829773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6889513731002808},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.6566685438156128},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5777713060379028},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5649181008338928},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5512158870697021},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5330459475517273},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3505488336086273},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3447721302509308},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3207595944404602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16870790719985962},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053244","descriptor_name":"Osteoprotegerin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.13.6.849","doi":"https://doi.org/10.3892/ijmm.13.6.849","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.13.6.849","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:15138623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15138623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321499","display_name":"Fondazione Cariplo","ror":"https://ror.org/01gb56c55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3131835296","https://openalex.org/W2607173357","https://openalex.org/W4386501742","https://openalex.org/W2178087668","https://openalex.org/W7007937193","https://openalex.org/W2119589807","https://openalex.org/W2341722459","https://openalex.org/W3016132114","https://openalex.org/W4399918167","https://openalex.org/W2744986294"],"abstract_inverted_index":{"Elevated":[0],"level":[1],"of":[2,34,50,63,151,181,205,212],"osteoprotegerin":[3],"(OPG),":[4],"a":[5,37,178,200],"pleiotropic":[6],"cytokine":[7],"involved":[8],"in":[9,40,58,88,99,183,202,209],"bone":[10],"metabolism,":[11],"has":[12],"been":[13],"associated":[14,147],"with":[15,148],"coronary":[16],"heart":[17],"disease":[18,38,46],"and":[19,44,70,78,91,110,138,160],"higher":[20,98],"cardiovascular":[21,24],"mortality.":[22],"Because":[23],"disorders":[25],"are":[26],"recognized":[27],"risk":[28],"factors":[29,135,195],"for":[30,76,133],"dementia,":[31],"the":[32,149,184,191,203,210],"study":[33,170],"OPG":[35,52,81,94,143,173],"as":[36,177],"marker":[39],"vascular":[41,194],"dementia":[42,182],"(VaD)":[43],"Alzheimer's":[45],"(AD)":[47],"seemed":[48],"worthy":[49],"investigation.":[51],"concentration":[53],"was":[54],"determined":[55],"by":[56],"ELISA":[57],"an":[59],"Italian":[60,185],"cohort":[61],"consisting":[62],"39":[64,71],"VaD":[65,101,152,206],"patients,":[66,69],"36":[67],"AD":[68,111,161],"non-demented":[72,92,122],"controls":[73,123],"strictly":[74],"matched":[75],"age":[77,87],"gender.":[79],"Plasma":[80],"levels":[82,144],"were":[83,96],"positively":[84],"related":[85],"to":[86,121],"both":[89,100],"demented":[90],"persons.":[93],"concentrations":[95],"significantly":[97],"(median:":[102,112,124],"4.75":[103],"pmol/l;":[104,108,114,118],"interquartile":[105,115,127],"range:":[106,116,128],"3.42-6.85":[107],"P<0.0001)":[109],"4.02":[113],"3.07-4.77":[117],"P=0.0278)":[119],"compared":[120],"3.24":[125],"pmol/l,":[126],"2.70-3.98":[129],"pmol/l).":[130],"After":[131],"allowance":[132],"confounding":[134],"(age,":[136],"gender":[137],"APOE":[139],"epsilon4":[140],"allele),":[141],"plasma":[142],"remained":[145],"independently":[146],"presence":[150],"(OR":[153,162],"=":[154,163],"2.51;":[155],"95%":[156,165],"CI":[157,166],"1.46-4.32;":[158],"P=0.0009)":[159],"2.17;":[164],"1.18-3.99;":[167],"P=0.0126).":[168],"Our":[169],"demonstrates":[171],"that":[172,193],"may":[174,196],"be":[175],"regarded":[176],"novel":[179],"biomarker":[180],"population.":[186],"These":[187],"results":[188],"further":[189],"support":[190],"hypothesis":[192],"not":[197],"only":[198],"play":[199],"role":[201],"pathogenesis":[204,211],"but":[207],"also":[208],"AD.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
