{"id":"https://openalex.org/W2048837843","doi":"https://doi.org/10.1111/j.1399-3038.2008.00757.x","title":"Association of early growth response\u20101 gene polymorphisms with total IgE and atopy in asthmatic children","display_name":"Association of early growth response\u20101 gene polymorphisms with total IgE and atopy in asthmatic children","publication_year":2008,"publication_date":"2008-05-28","ids":{"openalex":"https://openalex.org/W2048837843","doi":"https://doi.org/10.1111/j.1399-3038.2008.00757.x","mag":"2048837843","pmid":"https://pubmed.ncbi.nlm.nih.gov/18507785"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-3038.2008.00757.x","doi":"https://doi.org/10.1111/j.1399-3038.2008.00757.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3038.2008.00757.x","pdf_url":null,"source":{"id":"https://openalex.org/S191932905","display_name":"Pediatric Allergy and Immunology","issn_l":"0905-6157","issn":["0905-6157","1399-3038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Allergy and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108293362","display_name":"Iris Hiu-Shuen Chan","orcid":"https://orcid.org/0009-0004-6650-7610","observed_orcids":["https://orcid.org/0009-0004-6650-7610"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Iris H. S. Chan","raw_affiliation_strings":["Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong","Department of Chemical Pathology","These authors contributed equally to this manuscript"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Department of Chemical Pathology","institution_ids":[]},{"raw_affiliation_string":"These authors contributed equally to this manuscript","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100735664","display_name":"Nelson L.S. Tang","orcid":"https://orcid.org/0000-0002-3607-5819","observed_orcids":["https://orcid.org/0000-0002-3607-5819"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nelson L. S. Tang","raw_affiliation_strings":["Department of Chemical Pathology","Joint Laboratory of Bioresource and Molecular Research of Common Disease","Li Ka Shing Institute of Health Sciences","These authors contributed equally to this manuscript"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology","institution_ids":[]},{"raw_affiliation_string":"Joint Laboratory of Bioresource and Molecular Research of Common Disease","institution_ids":[]},{"raw_affiliation_string":"Li Ka Shing Institute of Health Sciences","institution_ids":[]},{"raw_affiliation_string":"These authors contributed equally to this manuscript","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085633609","display_name":"Ting Fan Leung","orcid":"https://orcid.org/0000-0002-6469-1926","observed_orcids":["https://orcid.org/0000-0002-6469-1926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting F. Leung","raw_affiliation_strings":["Departments of Paediatrics","Joint Laboratory of Bioresource and Molecular Research of Common Disease","These authors contributed equally to this manuscript"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Paediatrics","institution_ids":[]},{"raw_affiliation_string":"Joint Laboratory of Bioresource and Molecular Research of Common Disease","institution_ids":[]},{"raw_affiliation_string":"These authors contributed equally to this manuscript","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"W. Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Huang","raw_affiliation_strings":["Department of Chemical Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013908037","display_name":"Yvonne Yi On Lam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yvonne Y. O. Lam","raw_affiliation_strings":["Department of Chemical Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074602745","display_name":"Gary Wong","orcid":"https://orcid.org/0000-0001-5939-812X","observed_orcids":["https://orcid.org/0000-0001-5939-812X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary W. K. Wong","raw_affiliation_strings":["Departments of Paediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Paediatrics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091832416","display_name":"Juliana C.N. Chan","orcid":"https://orcid.org/0000-0003-1325-1194","observed_orcids":["https://orcid.org/0000-0003-1325-1194"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Juliana C. N. Chan","raw_affiliation_strings":["Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057462303","display_name":"Michael H.M. Chan","orcid":"https://orcid.org/0000-0003-1949-1666","observed_orcids":["https://orcid.org/0000-0003-1949-1666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael H. M. Chan","raw_affiliation_strings":["Department of Chemical Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075382903","display_name":"Chun Kwok Wong","orcid":"https://orcid.org/0000-0002-5637-8331","observed_orcids":["https://orcid.org/0000-0002-5637-8331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun K. Wong","raw_affiliation_strings":["Department of Chemical Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071922450","display_name":"Ya P. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya P. Zhang","raw_affiliation_strings":["Joint Laboratory of Bioresource and Molecular Research of Common Disease","Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Bioresource and Molecular Research of Common Disease","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063663865","display_name":"Christopher Wai Kei Lam","orcid":"https://orcid.org/0000-0003-3994-2030","observed_orcids":["https://orcid.org/0000-0003-3994-2030"]},"institutions":[{"id":"https://openalex.org/I4391767947","display_name":"Macau University of Science and Technology Foundation","ror":"https://ror.org/02avx9m34","country_code":"MO","type":"nonprofit","lineage":["https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":true,"raw_author_name":"Christopher W. K. Lam","raw_affiliation_strings":["Department of Chemical Pathology","Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology Foundation, Macau"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology","institution_ids":[]},{"raw_affiliation_string":"Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology Foundation, Macau","institution_ids":["https://openalex.org/I4391767947"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5063663865"],"corresponding_institution_ids":["https://openalex.org/I4391767947"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":0.9024,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.7546358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"20","issue":"2","first_page":"142","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-growth-response-1","display_name":"early growth response 1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9470000267028809},{"id":"https://openalex.org/keywords/total-serum-ige","display_name":"total IgE","score":0.699999988079071},{"id":"https://openalex.org/keywords/atopy","display_name":"atopy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6669999957084656},{"id":"https://openalex.org/keywords/chinese-children","display_name":"Chinese children","score":0.46299999952316284},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.8812338709831238},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8404725193977356},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.727712869644165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6955456733703613},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5876554250717163},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5630490183830261},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5355380177497864},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5145627856254578},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5076311826705933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.436562716960907},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.19975200295448303},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19043821096420288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18924221396446228},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1759670078754425}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003058","descriptor_name":"Cockroaches","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013147","descriptor_name":"Spirometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039741","descriptor_name":"Antigens, Dermatophagoides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D040002","descriptor_name":"Dermatophagoides pteronyssinus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1399-3038.2008.00757.x","doi":"https://doi.org/10.1111/j.1399-3038.2008.00757.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3038.2008.00757.x","pdf_url":null,"source":{"id":"https://openalex.org/S191932905","display_name":"Pediatric Allergy and Immunology","issn_l":"0905-6157","issn":["0905-6157","1399-3038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Allergy and Immunology","raw_type":"journal-article"},{"id":"pmid:18507785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18507785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322170","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86"},{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W4443349","https://openalex.org/W105381371","https://openalex.org/W1512090235","https://openalex.org/W1567881416","https://openalex.org/W1642011293","https://openalex.org/W1972215399","https://openalex.org/W1984767179","https://openalex.org/W1990215671","https://openalex.org/W1991727971","https://openalex.org/W1992938326","https://openalex.org/W1995529555","https://openalex.org/W2001178280","https://openalex.org/W2003869191","https://openalex.org/W2007577379","https://openalex.org/W2010458075","https://openalex.org/W2023906945","https://openalex.org/W2027154318","https://openalex.org/W2037499241","https://openalex.org/W2059008263","https://openalex.org/W2065801967","https://openalex.org/W2066650638","https://openalex.org/W2083754122","https://openalex.org/W2091842964","https://openalex.org/W2092002446","https://openalex.org/W2096033851","https://openalex.org/W2108868985","https://openalex.org/W2124790523","https://openalex.org/W2138312725","https://openalex.org/W2140411489","https://openalex.org/W2159311328","https://openalex.org/W2162291597","https://openalex.org/W2162530578","https://openalex.org/W2334264687","https://openalex.org/W2408484017","https://openalex.org/W3144191822","https://openalex.org/W4236639597","https://openalex.org/W4242213537"],"related_works":["https://openalex.org/W2063784685","https://openalex.org/W4312945702","https://openalex.org/W2078021268","https://openalex.org/W2126503185","https://openalex.org/W1997253646","https://openalex.org/W2164141929","https://openalex.org/W2436330249","https://openalex.org/W2084380749","https://openalex.org/W4380361595","https://openalex.org/W1937970505"],"abstract_inverted_index":{"Early":[0],"growth":[1],"response-1":[2],"(Egr-1)":[3],"is":[4,217],"expressed":[5],"in":[6,24,41,103,135,152,234],"human":[7],"airways":[8],"and":[9,21,46,49,61,69,90,96,143,177,199,232],"found":[10,84],"to":[11,221,239],"modulate":[12],"tumor":[13],"necrosis":[14],"factor,":[15],"immunoglobulin":[16],"E":[17],"(IgE),":[18],"airway":[19],"responsiveness,":[20],"interleukin-13-induced":[22],"inflammation":[23],"mice.":[25],"We":[26],"investigated":[27],"the":[28,138,155,159,189,213,218,241],"effects":[29],"of":[30,36,54,127,196,203,225,243],"Chinese-tagging":[31],"single":[32],"nucleotide":[33],"polymorphisms":[34,227],"(SNPs)":[35],"Egr-1":[37,226,244],"on":[38],"asthma":[39],"traits":[40],"298":[42],"Chinese":[43],"asthmatic":[44,104],"children":[45],"175":[47],"controls,":[48],"a":[50,123,193,200],"replication":[51],"community":[52],"cohort":[53],"191":[55],"controls.":[56],"Tag":[57],"SNP":[58],"(-4071":[59],"A-->G)":[60],"three":[62,139],"additional":[63],"SNPs":[64,140],"(-1427":[65],"C-->T,":[66],"-151":[67],"C-->T":[68,99],"IVS1":[70,97],"-42":[71,98],"C-->T)":[72],"were":[73,83],"genotyped":[74],"by":[75],"restriction":[76],"fragment":[77],"length":[78],"polymorphism":[79],"(RFLP).":[80],"Significant":[81],"associations":[82],"between":[85],"plasma":[86,229],"total":[87,179,206,230],"IgE":[88,180,207,231],"concentration":[89,181,208],"-4071":[91,110,146,167],"A-->G":[92,111,168],"(p":[93,100,162,174,182],"=":[94,101,133,163,175,183],"0.008)":[95],"0.027)":[102],"patients.":[105],"After":[106],"Bonferroni":[107],"correction,":[108],"only":[109],"showed":[112],"significant":[113,120,223],"association.":[114],"Multivariate":[115],"regression":[116],"analysis":[117],"confirmed":[118],"this":[119],"association":[121,224],"with":[122,141,154,172,188,228],"standardized":[124],"coefficient":[125],"beta":[126],"0.156":[128],"(95%":[129],"CI:":[130],"0.046-0.317;":[131],"p":[132],"0.009)":[134],"asthmatics":[136],"among":[137,185],"age":[142],"gender-adjusted.":[144],"In":[145,165],"A-->G,":[147],"IgE(log)":[148],"was":[149,169],"significantly":[150,170],"higher":[151],"patients":[153],"GG":[156],"genotype":[157,161],"than":[158,209],"AA":[160],"0.009).":[164],"addition,":[166],"associated":[171],"atopy":[173,198,233],"0.016)":[176],"high":[178,205],"0.030)":[184],"asthmatics.":[186,235],"Patients":[187],"G":[190],"allele":[191],"had":[192],"3.5-fold":[194],"risk":[195,202],"having":[197,204],"2.0-fold":[201],"those":[210],"homozygous":[211],"for":[212],"A":[214],"allele.":[215],"This":[216],"first":[219],"report":[220],"show":[222],"It":[236],"may":[237],"help":[238],"explore":[240],"pharmacogenetics":[242],"inhibitors.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}