{"id":"https://openalex.org/W2048815512","doi":"https://doi.org/10.4236/aad.2013.23014","title":"Calcineurin overexpression regulates APP metabolism","display_name":"Calcineurin overexpression regulates APP metabolism","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2048815512","doi":"https://doi.org/10.4236/aad.2013.23014","mag":"2048815512"},"language":"en","primary_location":{"id":"doi:10.4236/aad.2013.23014","doi":"https://doi.org/10.4236/aad.2013.23014","is_oa":true,"landing_page_url":"https://doi.org/10.4236/aad.2013.23014","pdf_url":"https://doi.org/10.4236/aad.2013.23014","source":{"id":"https://openalex.org/S4210197819","display_name":"Advances in Alzheimer s Disease","issn_l":"2169-2459","issn":["2169-2459","2169-2467"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4236/aad.2013.23014","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043104216","display_name":"Suruchi Utreja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suruchi Utreja","raw_affiliation_strings":["Department of Biology, Drexel University, Philadelphia, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Drexel University, Philadelphia, USA;","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013888616","display_name":"Sean Miller","orcid":"https://orcid.org/0000-0003-1432-9547","observed_orcids":["https://orcid.org/0000-0003-1432-9547"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean J. Miller","raw_affiliation_strings":["Department of Biology, Drexel University, Philadelphia, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Drexel University, Philadelphia, USA;","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061553021","display_name":"Aleister J. Saunders","orcid":"https://orcid.org/0000-0002-7298-7823","observed_orcids":["https://orcid.org/0000-0002-7298-7823"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleister Saunders","raw_affiliation_strings":["Department of Biology, Drexel University, Philadelphia, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Drexel University, Philadelphia, USA;","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I72816309"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.14286658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"02","issue":"03","first_page":"109","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7670000195503235},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8169999718666077},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7889999747276306},{"id":"https://openalex.org/keywords/app-processing","display_name":"APP processing","score":0.753000020980835},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6449999809265137},{"id":"https://openalex.org/keywords/feedforward-loop","display_name":"feed-forward loop","score":0.6510000228881836},{"id":"https://openalex.org/keywords/app-proteolysis","display_name":"APP proteolysis","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.810073971748352},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4500279724597931},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41674983501434326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3822013735771179},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34300553798675537},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3338015377521515},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19301289319992065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1895594596862793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14064070582389832},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.07734501361846924}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4236/aad.2013.23014","doi":"https://doi.org/10.4236/aad.2013.23014","is_oa":true,"landing_page_url":"https://doi.org/10.4236/aad.2013.23014","pdf_url":"https://doi.org/10.4236/aad.2013.23014","source":{"id":"https://openalex.org/S4210197819","display_name":"Advances in Alzheimer s Disease","issn_l":"2169-2459","issn":["2169-2459","2169-2467"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1030.4214","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1030.4214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://file.scirp.org/pdf/_2013092611521190.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.4236/aad.2013.23014","doi":"https://doi.org/10.4236/aad.2013.23014","is_oa":true,"landing_page_url":"https://doi.org/10.4236/aad.2013.23014","pdf_url":"https://doi.org/10.4236/aad.2013.23014","source":{"id":"https://openalex.org/S4210197819","display_name":"Advances in Alzheimer s Disease","issn_l":"2169-2459","issn":["2169-2459","2169-2467"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Alzheimer's Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2048815512.pdf","grobid_xml":"https://content.openalex.org/works/W2048815512.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W3114575","https://openalex.org/W129188136","https://openalex.org/W291634622","https://openalex.org/W1486031693","https://openalex.org/W1550942186","https://openalex.org/W1970722804","https://openalex.org/W1972037461","https://openalex.org/W1977916691","https://openalex.org/W1978559408","https://openalex.org/W1981008245","https://openalex.org/W1983668432","https://openalex.org/W1988278010","https://openalex.org/W1991163286","https://openalex.org/W1997020265","https://openalex.org/W2002001849","https://openalex.org/W2006459253","https://openalex.org/W2009062700","https://openalex.org/W2017842551","https://openalex.org/W2023200476","https://openalex.org/W2033382511","https://openalex.org/W2035241896","https://openalex.org/W2043095820","https://openalex.org/W2049134173","https://openalex.org/W2061872586","https://openalex.org/W2062429423","https://openalex.org/W2064292592","https://openalex.org/W2067155622","https://openalex.org/W2074664011","https://openalex.org/W2085052787","https://openalex.org/W2093906292","https://openalex.org/W2094058760","https://openalex.org/W2102256305","https://openalex.org/W2107538476","https://openalex.org/W2120258938","https://openalex.org/W2131819352","https://openalex.org/W2153438315","https://openalex.org/W2158545447","https://openalex.org/W2172196619"],"related_works":["https://openalex.org/W4206313252","https://openalex.org/W2518688305","https://openalex.org/W2000789260","https://openalex.org/W7074059739","https://openalex.org/W2891927706","https://openalex.org/W2109467780","https://openalex.org/W2061872586","https://openalex.org/W1981008245","https://openalex.org/W1959120602","https://openalex.org/W2044904524"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,37,49,78,97,122],"a":[4,38,69,191],"complex":[5],"neurodegenerative":[6,88],"disease,":[7],"pathologically":[8],"characterized":[9],"by":[10,26,60,184],"the":[11,23,27,32,56,64,81,100],"accumulation":[12],"of":[13,22,31,55,66,80,90,94,99,106,128,146,166,174,187],"\u03b2-amyloid":[14,33],"peptide":[15,25],"(A\u03b2)":[16],"and":[17,72,87,162],"intraneuronal":[18],"neurofibrillary":[19],"tangles.":[20],"Production":[21],"A\u03b2":[24,52,136],"regulated":[28],"intra-membrane":[29],"proteolysis":[30],"precursor":[34],"protein":[35,76],"(APP)":[36],"central":[39],"event":[40],"in":[41,46,104,130,182],"AD.":[42],"Cognitive":[43],"decline":[44],"observed":[45,181],"AD":[47,109,131,183],"models":[48],"dependent":[50],"on":[51],"generation.":[53],"One":[54],"downstream":[57],"effects":[58,89],"mediated":[59],"solubleA\u03b2":[61],"oligomers":[62],"includes":[63],"hyperactivation":[65],"calcineurin":[67],"(CaN),":[68],"Ca":[70],"2+":[71],"calmodulin":[73],"(CaM)-dependent,":[74],"serinethreonine":[75],"phosphatase.CaN":[77],"one":[79,98],"major":[82],"phosphatase":[83],"associated":[84],"with":[85],"cognitive":[86],"A\u03b2.A":[91],"specific":[92],"isoform":[93],"CaN,":[95],"CaNA\u03b2,":[96],"most":[101],"up-regulated":[102],"mRNAs":[103],"brains":[105],"early":[107],"stage":[108],"patients.While":[110],"A\u03b2's":[111],"ability":[112],"to":[113,158,179],"activate":[114],"CaN":[115,129,175],"has":[116],"been":[117],"well":[118],"studied,":[119],"not":[120],"much":[121],"known":[123],"about":[124],"how":[125],"increased":[126,144,154,159,163],"levels":[127,145,161,176,186],"brain":[132],"can":[133],"contribute":[134,178],"towards":[135],"generation.In":[137],"this":[138],"study":[139],"we":[140],"specifically":[141],"investigate":[142],"if":[143],"CaNA\u03b2":[147,155],"regulate":[148],"APP":[149,160],"metabolism.Our":[150],"results":[151],"demonstrate":[152],"that":[153,172],"expression":[156],"leads":[157],"proteolytic":[164],"products":[165],"APP,":[167],"including":[168],"A\u03b2.The":[169],"data":[170],"suggest":[171],"upregulation":[173],"could":[177],"neurodegeneration":[180],"increasing":[185],"A\u03b2,":[188],"potentially":[189],"forming":[190],"pathogenic":[192],"feed":[193],"forward":[194],"loop.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}