{"id":"https://openalex.org/W2048765000","doi":"https://doi.org/10.1073/pnas.1002301107","title":"Plasmacytoid dendritic cells sense hepatitis C virus\u2013infected cells, produce interferon, and inhibit infection","display_name":"Plasmacytoid dendritic cells sense hepatitis C virus\u2013infected cells, produce interferon, and inhibit infection","publication_year":2010,"publication_date":"2010-03-15","ids":{"openalex":"https://openalex.org/W2048765000","doi":"https://doi.org/10.1073/pnas.1002301107","mag":"2048765000","pmid":"https://pubmed.ncbi.nlm.nih.gov/20231459","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2867703"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1002301107","doi":"https://doi.org/10.1073/pnas.1002301107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1002301107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2867703","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076551859","display_name":"Ken Takahashi","orcid":"https://orcid.org/0000-0002-7310-2257","observed_orcids":["https://orcid.org/0000-0002-7310-2257"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Takahashi","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075549982","display_name":"Shinichi Asabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shinichi Asabe","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051928481","display_name":"Stefan F. Wieland","orcid":"https://orcid.org/0000-0002-4444-977X","observed_orcids":["https://orcid.org/0000-0002-4444-977X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Wieland","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011327938","display_name":"Urtzi Garaigorta","orcid":"https://orcid.org/0000-0002-0683-5725","observed_orcids":["https://orcid.org/0000-0002-0683-5725"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Urtzi Garaigorta","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081961105","display_name":"Pablo Gastaminza","orcid":"https://orcid.org/0000-0002-7873-5491","observed_orcids":["https://orcid.org/0000-0002-7873-5491"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo Gastaminza","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073157558","display_name":"Masanori Isogawa","orcid":"https://orcid.org/0000-0001-8730-4303","observed_orcids":["https://orcid.org/0000-0001-8730-4303"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Isogawa","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004916033","display_name":"Francis V. Chisari","orcid":"https://orcid.org/0000-0002-4832-1044","observed_orcids":["https://orcid.org/0000-0002-4832-1044"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Francis V. Chisari","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004916033"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":11.7938,"has_fulltext":false,"cited_by_count":268,"citation_normalized_percentile":{"value":0.9914948,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"107","issue":"16","first_page":"7431","last_page":"7436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.875},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.6570000052452087},{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.925000011920929},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.625},{"id":"https://openalex.org/keywords/interferon-receptor","display_name":"interferon receptor","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hcv-subgenomic-replicon","display_name":"HCV subgenomic replicon","score":0.7889999747276306},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.7551730275154114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7466284036636353},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7167187929153442},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5700604319572449},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5673502683639526},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47726863622665405},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.46089428663253784},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34107545018196106},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18960285186767578}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1002301107","doi":"https://doi.org/10.1073/pnas.1002301107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1002301107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2867703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2867703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:20231459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20231459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/345640","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/345640","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2867703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2867703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2180012982","display_name":"Innate Control of Hepatitis C Virus Infection: Antiviral and Evasion Mechanisms","funder_award_id":"R56AI079043","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3974511421","display_name":null,"funder_award_id":"AI-079043","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5544881829","display_name":"Innate Control of Hepatitis C Virus  Infection: Antiviral and Evasion Mechanisms","funder_award_id":"R01AI079043","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5953358903","display_name":"CELLULAR GENES THAT CONTROL HCV REPLICATION","funder_award_id":"R01CA108304","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8883367568","display_name":null,"funder_award_id":"HEK293","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320309680","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333295","display_name":"Lerner Research Institute, Cleveland Clinic","ror":null},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1502104604","https://openalex.org/W1561788579","https://openalex.org/W1967491261","https://openalex.org/W1974733477","https://openalex.org/W1978741561","https://openalex.org/W1986315531","https://openalex.org/W1994391392","https://openalex.org/W2002442746","https://openalex.org/W2021068494","https://openalex.org/W2023645777","https://openalex.org/W2026101939","https://openalex.org/W2041442788","https://openalex.org/W2044193462","https://openalex.org/W2069823852","https://openalex.org/W2071670416","https://openalex.org/W2076294822","https://openalex.org/W2076815050","https://openalex.org/W2077467499","https://openalex.org/W2078586740","https://openalex.org/W2079007590","https://openalex.org/W2084009106","https://openalex.org/W2086068563","https://openalex.org/W2093579074","https://openalex.org/W2097135837","https://openalex.org/W2109708832","https://openalex.org/W2110525565","https://openalex.org/W2112222308","https://openalex.org/W2118537722","https://openalex.org/W2118926211","https://openalex.org/W2129708174","https://openalex.org/W2136011975","https://openalex.org/W2138038141","https://openalex.org/W2147727360","https://openalex.org/W2152620027","https://openalex.org/W2156089065","https://openalex.org/W2160632084","https://openalex.org/W2167044622","https://openalex.org/W2169686453"],"related_works":["https://openalex.org/W2907269670","https://openalex.org/W7099322689","https://openalex.org/W2030629842","https://openalex.org/W2019159816","https://openalex.org/W7097430130","https://openalex.org/W1976467819","https://openalex.org/W2528695945","https://openalex.org/W2040960293","https://openalex.org/W2465117483","https://openalex.org/W2135059690"],"abstract_inverted_index":{"Hepatitis":[0],"C":[1],"virus":[2,15,138],"(HCV),":[3],"a":[4,11,50,82,92,144,177],"member":[5],"of":[6,63,143,181],"the":[7,37,58,111,124,141,172,182,191,196],"Flaviviridae":[8],"family,":[9],"is":[10,70],"single-stranded":[12],"positive-sense":[13],"RNA":[14,147],"that":[16,78,94,110,188],"infects":[17],">170":[18],"million":[19],"people":[20],"worldwide":[21],"and":[22,25,29,67,102,107,174,200],"causes":[23],"acute":[24],"chronic":[26],"hepatitis,":[27],"cirrhosis,":[28],"hepatocellular":[30],"carcinoma.":[31],"Despite":[32],"its":[33],"ability":[34],"to":[35,156,186],"block":[36],"innate":[38,183],"host":[39,184],"response":[40,56,85,185],"in":[41,46,57,65,86,118,171,195],"infected":[42,59],"hepatocyte":[43],"cell":[44],"lines":[45],"vitro,":[47],"HCV":[48,116,130,167],"induces":[49,168],"strong":[51],"type":[52],"1":[53],"interferon":[54],"(IFN)":[55],"liver.":[60],"The":[61],"source":[62],"IFN":[64,84,120,158,169],"vivo":[66],"how":[68,166],"it":[69],"induced":[71],"are":[72,127],"currently":[73],"undefined.":[74],"Here":[75],"we":[76,108],"report":[77],"HCV-infected":[79,151],"cells":[80,89,133,152,197],"trigger":[81],"robust":[83],"plasmacytoid":[87],"dendritic":[88],"(pDCs)":[90],"by":[91,129,136],"mechanism":[93],"requires":[95],"active":[96],"viral":[97],"replication,":[98],"direct":[99],"cell-cell":[100,146],"contact,":[101],"Toll-like":[103],"receptor":[104],"7":[105],"signaling,":[106],"show":[109],"activated":[112],"pDC":[113],"supernatant":[114],"inhibits":[115],"infection":[117],"an":[119],"receptor-dependent":[121],"manner.":[122],"Importantly,":[123],"same":[125],"events":[126],"triggered":[128],"subgenomic":[131],"replicon":[132],"but":[134],"not":[135,202],"free":[137],"particles,":[139],"suggesting":[140],"existence":[142],"novel":[145],"transfer":[148],"process":[149],"whereby":[150],"can":[153,189],"activate":[154,206],"pDCs":[155],"produce":[157],"without":[159],"infecting":[160],"them.":[161],"These":[162],"results":[163],"may":[164],"explain":[165],"production":[170],"liver,":[173],"they":[175,198],"reveal":[176],"heretofore":[178],"unsuspected":[179],"aspect":[180],"viruses":[187],"subvert":[190],"classical":[192],"sensing":[193],"machinery":[194],"infect,":[199],"do":[201],"infect":[203],"or":[204],"directly":[205],"pDCs.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}