{"id":"https://openalex.org/W2048743237","doi":"https://doi.org/10.1073/pnas.0507225103","title":"Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons","display_name":"Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons","publication_year":2006,"publication_date":"2006-01-03","ids":{"openalex":"https://openalex.org/W2048743237","doi":"https://doi.org/10.1073/pnas.0507225103","mag":"2048743237","pmid":"https://pubmed.ncbi.nlm.nih.gov/16407156","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1326162"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0507225103","doi":"https://doi.org/10.1073/pnas.0507225103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0507225103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1326162","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005788321","display_name":"Eric Beitz","orcid":"https://orcid.org/0000-0001-5912-6626","observed_orcids":["https://orcid.org/0000-0001-5912-6626"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","DK"],"is_corresponding":false,"raw_author_name":"Eric Beitz","raw_affiliation_strings":["Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063574519","display_name":"Binghua Wu","orcid":"https://orcid.org/0000-0002-1008-7678","observed_orcids":["https://orcid.org/0000-0002-1008-7678"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","DK"],"is_corresponding":false,"raw_author_name":"Binghua Wu","raw_affiliation_strings":["Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lars M. Holm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","DK"],"is_corresponding":false,"raw_author_name":"Lars M. Holm","raw_affiliation_strings":["Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004439886","display_name":"Joachim Erdmann Schultz","orcid":"https://orcid.org/0000-0002-1985-4853","observed_orcids":["https://orcid.org/0000-0002-1985-4853"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","DK"],"is_corresponding":false,"raw_author_name":"Joachim E. Schultz","raw_affiliation_strings":["Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042786766","display_name":"Thomas Zeuthen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","DK"],"is_corresponding":false,"raw_author_name":"Thomas Zeuthen","raw_affiliation_strings":["Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, University of T\u00fcbingen, Morgenstelle 8, D-72076 T\u00fcbingen, Germany; and Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3013,"has_fulltext":false,"cited_by_count":343,"citation_normalized_percentile":{"value":0.98021344,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"103","issue":"2","first_page":"269","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aquaporin-1","display_name":"aquaporin-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/solute-permeability","display_name":"solute permeability","score":0.6840000152587891},{"id":"https://openalex.org/keywords/urea-permeability","display_name":"urea permeability","score":0.8190000057220459},{"id":"https://openalex.org/keywords/glycerol-permeability","display_name":"glycerol permeability","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ammonia-permeability","display_name":"ammonia permeability","score":0.9179999828338623},{"id":"https://openalex.org/keywords/proton-permeability","display_name":"proton permeability","score":0.9210000038146973},{"id":"https://openalex.org/keywords/npa-motif","display_name":"NPA motif","score":0.5659999847412109},{"id":"https://openalex.org/keywords/water-permeability","display_name":"water permeability","score":0.6050000190734863},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.5809999704360962},{"id":"https://openalex.org/keywords/pore-constriction","display_name":"pore constriction","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6155499219894409},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.5999711751937866},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5375795960426331},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.5203565955162048},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.486316055059433},{"id":"https://openalex.org/C2775895851","wikidata":"https://www.wikidata.org/wiki/Q185906","display_name":"Asparagine","level":3,"score":0.45802223682403564},{"id":"https://openalex.org/C154280991","wikidata":"https://www.wikidata.org/wiki/Q623090","display_name":"Aquaporin","level":2,"score":0.4232219457626343},{"id":"https://openalex.org/C2776382133","wikidata":"https://www.wikidata.org/wiki/Q4087","display_name":"Ammonia","level":2,"score":0.4213860332965851},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4178650379180908},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.4150938093662262},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4015429615974426},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.25483644008636475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23505526781082153},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051398","descriptor_name":"Aquaporin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051398","descriptor_name":"Aquaporin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051398","descriptor_name":"Aquaporin 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.0507225103","doi":"https://doi.org/10.1073/pnas.0507225103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0507225103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:291099","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1326162","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:16407156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16407156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1326162","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1326162/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/6a616b50-6c38-11dc-bee9-02004c4f4f50","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/6a616b50-6c38-11dc-bee9-02004c4f4f50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Beitz, E, Wu, B, Holm, L M, Schultz, J E & Zeuthen, T 2006, 'Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia and protons', Proceedings of the National Academy of Science of the United States of America, no. 103(2), pp. 269-274. https://doi.org/10.1073/pnas.0507225103","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:291099","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1326162","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W13880714","https://openalex.org/W61051756","https://openalex.org/W1254580001","https://openalex.org/W1492555480","https://openalex.org/W1501773294","https://openalex.org/W1504082382","https://openalex.org/W1559236087","https://openalex.org/W1566695422","https://openalex.org/W1578684030","https://openalex.org/W1805989424","https://openalex.org/W1947778485","https://openalex.org/W1967096577","https://openalex.org/W1971909283","https://openalex.org/W1983417964","https://openalex.org/W1994179682","https://openalex.org/W1995087505","https://openalex.org/W1998467122","https://openalex.org/W1998548799","https://openalex.org/W2010182284","https://openalex.org/W2011357793","https://openalex.org/W2027153868","https://openalex.org/W2060594600","https://openalex.org/W2071375439","https://openalex.org/W2078936885","https://openalex.org/W2092398899","https://openalex.org/W2102589827","https://openalex.org/W2105546584","https://openalex.org/W2107452580","https://openalex.org/W2114489396","https://openalex.org/W2115579471","https://openalex.org/W2127270784","https://openalex.org/W2145611758","https://openalex.org/W2407923760","https://openalex.org/W3206572385"],"related_works":["https://openalex.org/W2055635231","https://openalex.org/W1997329885","https://openalex.org/W7110618899","https://openalex.org/W2623538715","https://openalex.org/W1982230840","https://openalex.org/W7110539447","https://openalex.org/W1498453842","https://openalex.org/W2112561074","https://openalex.org/W2997971220","https://openalex.org/W72549787"],"abstract_inverted_index":{"Water-specific":[0],"aquaporins":[1],"(AQP),":[2],"such":[3],"as":[4,141,226,228],"the":[5,11,28,37,45,51,57,101,115,119,158,178,182,192,202,214,223,229],"prototypical":[6],"mammalian":[7],"AQP1,":[8],"stringently":[9],"exclude":[10],"passage":[12,193],"of":[13,32,53,71,108,118,147,168,177,194],"solutes,":[14],"ions,":[15],"and":[16,40,62,73,77,83,111,123,126,163,187,212],"even":[17],"protons.":[18],"Supposedly,":[19],"this":[20],"is":[21,205],"accomplished":[22],"by":[23,75,105,144,154,165],"two":[24],"conserved":[25],"regions":[26],"within":[27],"pore,":[29],"a":[30,206],"pair":[31],"canonical":[33],"asparagine-proline-alanine":[34],"(NPA)":[35],"motifs,":[36],"central":[38],"constriction,":[39,44],"an":[41],"aromatic/arginine":[42],"(ar/R)":[43],"outer":[46],"constriction.":[47,231],"Here,":[48],"we":[49],"analyzed":[50],"function":[52],"three":[54],"residues":[55],"in":[56,64,173,181,185,219],"ar/R":[58,120,183,203,230],"constriction":[59,121,184,204,225],"(Phe-56,":[60],"His-180,":[61],"Arg-195)":[63],"rat":[65],"AQP1.":[66,197],"Individual":[67],"or":[68],"joint":[69],"replacement":[70,107],"His-180":[72,112],"Arg-195":[74],"alanine":[76],"valine":[78],"residues,":[79],"respectively":[80],"(AQP1-H180A,":[81],"AQP1-R195V,":[82],"AQP1-H180A/R195V),":[84],"did":[85],"not":[86],"affect":[87],"water":[88],"permeability.":[89],"The":[90,198],"double":[91],"mutant":[92],"AQP1-H180A/R195V":[93,188],"allowed":[94],"urea":[95,127],"to":[96,128,190],"pass.":[97,129],"In":[98],"line":[99],"with":[100,151],"predicted":[102],"solute":[103,210],"discrimination":[104],"size,":[106],"both":[109,222],"Phe-56":[110],"(AQP1-F56A/H180A)":[113],"enlarged":[114],"maximal":[116],"diameter":[117],"3-fold":[122],"enabled":[124],"glycerol":[125],"We":[130],"further":[131],"show":[132],"that":[133,201,213],"ammonia":[134,155,169],"passes":[135],"through":[136,196],"all":[137],"four":[138],"AQP1":[139],"mutants,":[140],"determined":[142],"(i)":[143],"growth":[145],"complementation":[146],"yeast":[148],"deletion":[149],"strains":[150],"ammonia,":[152],"(ii)":[153],"uptake":[156],"from":[157],"external":[159],"solution":[160],"into":[161],"oocytes,":[162],"(iii)":[164],"direct":[166],"recordings":[167],"induced":[170],"proton":[171,217],"currents":[172],"oocytes.":[174],"Unexpectedly,":[175],"removal":[176],"positive":[179],"charge":[180],"AQP1-R195V":[186],"appeared":[189],"allow":[191],"protons":[195],"data":[199],"indicate":[200],"major":[207],"checkpoint":[208],"for":[209],"permeability,":[211],"exquisite":[215],"electrostatic":[216],"barrier":[218],"AQPs":[220],"comprises":[221],"NPA":[224],"well":[227]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
