{"id":"https://openalex.org/W2048725958","doi":"https://doi.org/10.1016/0006-3223(88)90016-9","title":"An examination of the opiate receptor subtypes labeled by [3H]cyclofoxy: An opiate antagonist suitable for positron emission tomography","display_name":"An examination of the opiate receptor subtypes labeled by [3H]cyclofoxy: An opiate antagonist suitable for positron emission tomography","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W2048725958","doi":"https://doi.org/10.1016/0006-3223(88)90016-9","mag":"2048725958","pmid":"https://pubmed.ncbi.nlm.nih.gov/2894229"},"language":"en","primary_location":{"id":"doi:10.1016/0006-3223(88)90016-9","doi":"https://doi.org/10.1016/0006-3223(88)90016-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-3223(88)90016-9","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103446078","display_name":"Richard B. Rothman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B. Rothman","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Bethesda, MD 20892","Laboratory of Preclinical Pharmacology (R.B.R.) National Institute of Mental Health, Bethesda, MD and St. Elizabeths Hospital (R.B.R.), Washington, D.C.USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology (R.B.R.) National Institute of Mental Health, Bethesda, MD and St. Elizabeths Hospital (R.B.R.), Washington, D.C.USA","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110618940","display_name":"Stafford McLean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stafford McLean","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology (R.B.R.) National Institute of Mental Health, Bethesda, MD and St. Elizabeths Hospital (R.B.R.), Washington, D.C.USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology (R.B.R.) National Institute of Mental Health, Bethesda, MD and St. Elizabeths Hospital (R.B.R.), Washington, D.C.USA","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5489,"currency":"USD","value_usd":5489},"apc_paid":null,"fwci":2.064,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.87011236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"23","issue":"5","first_page":"435","last_page":"458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.8169999718666077},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":1.0}],"concepts":[{"id":"https://openalex.org/C2778140631","wikidata":"https://www.wikidata.org/wiki/Q2026938","display_name":"Opiate","level":3,"score":0.7696733474731445},{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.7569286227226257},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6917491555213928},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.6413973569869995},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6094744205474854},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5872687697410583},{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.580378532409668},{"id":"https://openalex.org/C2909005528","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand Assay","level":3,"score":0.4867565631866455},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4686163067817688},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46858447790145874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43373528122901917},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.4140341877937317},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4126926362514496},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3964884281158447},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.37551772594451904},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3335617184638977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21532738208770752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13638123869895935},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004745","descriptor_name":"Enkephalins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013570","descriptor_name":"Synaptic Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020875","descriptor_name":"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-3223(88)90016-9","doi":"https://doi.org/10.1016/0006-3223(88)90016-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-3223(88)90016-9","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:2894229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2894229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W131478621","https://openalex.org/W201153995","https://openalex.org/W241407708","https://openalex.org/W1573840829","https://openalex.org/W1574798273","https://openalex.org/W1637481752","https://openalex.org/W1764777080","https://openalex.org/W1775749144","https://openalex.org/W1926302616","https://openalex.org/W1936333617","https://openalex.org/W1963839456","https://openalex.org/W1969777423","https://openalex.org/W1971541795","https://openalex.org/W1973839452","https://openalex.org/W1976026888","https://openalex.org/W1979385488","https://openalex.org/W1994068522","https://openalex.org/W1996997570","https://openalex.org/W2000050064","https://openalex.org/W2000149891","https://openalex.org/W2009559454","https://openalex.org/W2011449287","https://openalex.org/W2014649003","https://openalex.org/W2015503563","https://openalex.org/W2017379748","https://openalex.org/W2019953824","https://openalex.org/W2026933998","https://openalex.org/W2028012756","https://openalex.org/W2028731188","https://openalex.org/W2031235671","https://openalex.org/W2032643119","https://openalex.org/W2033324585","https://openalex.org/W2038651864","https://openalex.org/W2043001244","https://openalex.org/W2043813981","https://openalex.org/W2049676012","https://openalex.org/W2057432773","https://openalex.org/W2058338587","https://openalex.org/W2065441372","https://openalex.org/W2069269138","https://openalex.org/W2070316919","https://openalex.org/W2074725593","https://openalex.org/W2080428214","https://openalex.org/W2082679563","https://openalex.org/W2082801820","https://openalex.org/W2089108699","https://openalex.org/W2130617969","https://openalex.org/W2270012899","https://openalex.org/W2295765304","https://openalex.org/W2315066199","https://openalex.org/W2332470175","https://openalex.org/W2336020568","https://openalex.org/W2342102423","https://openalex.org/W2410839352","https://openalex.org/W2412334055","https://openalex.org/W2427973984","https://openalex.org/W2474896643","https://openalex.org/W4211071386","https://openalex.org/W4240184732","https://openalex.org/W6718872731"],"related_works":["https://openalex.org/W1971415798","https://openalex.org/W1986260532","https://openalex.org/W2043001244","https://openalex.org/W2069269138","https://openalex.org/W1967735651","https://openalex.org/W2038651864","https://openalex.org/W2038084663","https://openalex.org/W1958222516","https://openalex.org/W254113586","https://openalex.org/W2013863632"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}