{"id":"https://openalex.org/W2048675605","doi":"https://doi.org/10.1159/000065037","title":"Ameliorative Effect of Hepatocyte Growth Factor on Glycerol-Induced Acute Renal Failure with Acute Tubular Necrosis","display_name":"Ameliorative Effect of Hepatocyte Growth Factor on Glycerol-Induced Acute Renal Failure with Acute Tubular Necrosis","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2048675605","doi":"https://doi.org/10.1159/000065037","mag":"2048675605","pmid":"https://pubmed.ncbi.nlm.nih.gov/12138279"},"language":"en","primary_location":{"id":"doi:10.1159/000065037","doi":"https://doi.org/10.1159/000065037","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000065037","pdf_url":null,"source":{"id":"https://openalex.org/S4393917655","display_name":"The Nephron journals/Nephron journals","issn_l":"1660-8151","issn":["1660-8151","2235-3186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077729326","display_name":"Tomokazu Nagano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomokazu Nagano","raw_affiliation_strings":["Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075638012","display_name":"Ikue Mori\u2010Kudo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ikue Mori-Kudo","raw_affiliation_strings":["Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088443521","display_name":"Atsushi Tsuchida","orcid":"https://orcid.org/0000-0003-1271-6631","observed_orcids":["https://orcid.org/0000-0003-1271-6631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsushi Tsuchida","raw_affiliation_strings":["Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103371632","display_name":"Takao Kawamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takao Kawamura","raw_affiliation_strings":["Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022981263","display_name":"Mutsuo Taiji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mutsuo Taiji","raw_affiliation_strings":["Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008381839","display_name":"Hiroshi Noguchi","orcid":"https://orcid.org/0000-0001-9187-6611","observed_orcids":["https://orcid.org/0000-0001-9187-6611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Noguchi","raw_affiliation_strings":["Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1246,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.79322854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"91","issue":"4","first_page":"730","last_page":"738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":1.0},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9760000109672546},{"id":"https://openalex.org/keywords/acute-tubular-necrosis","display_name":"acute tubular necrosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/rhabdomyolysis","display_name":"rhabdomyolysis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.9390000104904175},{"id":"https://openalex.org/keywords/kidney-regeneration","display_name":"kidney regeneration","score":0.6119999885559082},{"id":"https://openalex.org/keywords/renal-recovery","display_name":"renal function recovery","score":0.492000013589859},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.8883241415023804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.711163341999054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6130207180976868},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5901244878768921},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5691825151443481},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.48401400446891785},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.45673370361328125},{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.4493456780910492},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3220398426055908},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1570982038974762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09015065431594849}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000065037","doi":"https://doi.org/10.1159/000065037","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000065037","pdf_url":null,"source":{"id":"https://openalex.org/S4393917655","display_name":"The Nephron journals/Nephron journals","issn_l":"1660-8151","issn":["1660-8151","2235-3186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron","raw_type":"journal-article"},{"id":"pmid:12138279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12138279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1965641790","https://openalex.org/W1970120554","https://openalex.org/W1975732704","https://openalex.org/W1981821798","https://openalex.org/W1986347387","https://openalex.org/W1995396825","https://openalex.org/W2002869143","https://openalex.org/W2005487014","https://openalex.org/W2007670239","https://openalex.org/W2008434851","https://openalex.org/W2014055440","https://openalex.org/W2025437703","https://openalex.org/W2043155095","https://openalex.org/W2044666189","https://openalex.org/W2048367533","https://openalex.org/W2048738742","https://openalex.org/W2052534316","https://openalex.org/W2054042846","https://openalex.org/W2070590535","https://openalex.org/W2072635469","https://openalex.org/W2077547816","https://openalex.org/W2091871375","https://openalex.org/W2162923280","https://openalex.org/W2166687975","https://openalex.org/W2209019250","https://openalex.org/W2337631781","https://openalex.org/W2346991516","https://openalex.org/W2411640738","https://openalex.org/W2411778756","https://openalex.org/W2436472070"],"related_works":["https://openalex.org/W2057941004","https://openalex.org/W2091871375","https://openalex.org/W1981821798","https://openalex.org/W2377478793","https://openalex.org/W1978616639","https://openalex.org/W1978999975","https://openalex.org/W2052534316","https://openalex.org/W2147078969","https://openalex.org/W2346991516","https://openalex.org/W1988660213"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Hepatocyte":[1],"growth":[2,7],"factor":[3],"(HGF),":[4],"a":[5,34],"multi-potent":[6],"factor,":[8],"is":[9],"known":[10],"to":[11,140],"promote":[12],"regeneration":[13],"of":[14,49,64,70,108,121,127,142,147,165,187,191,231],"damaged":[15],"renal":[16,26,170,178,207,232],"epithelial":[17],"cells.":[18],"Glycerol":[19,132],"injection":[20,63],"into":[21,66],"rats":[22,150],"induces":[23],"severe":[24,135,155],"acute":[25],"failure":[27],"(ARF)":[28],"with":[29,40],"ischemia":[30],"and":[31,85,91,101,105,119,195,212,234],"tubular":[32,166],"necrosis,":[33],"model":[35],"which":[36,137],"shares":[37],"many":[38],"features":[39],"human":[41],"ARF":[42,54,58,129,136,239],"or":[43,77],"rhabdomyolysis.":[44],"We":[45,113],"investigated":[46],"the":[47,67,109,125,143,169,192,200,203,206,229],"efficacy":[48],"HGF":[50,74,117,148,161,183,188,209,226],"in":[51,124,168,199,217,237],"this":[52],"glycerol-induced":[53,128,238],"rat":[55],"model.":[56],"METHODS:":[57],"was":[59,79,180,214],"induced":[60],"by":[61,154,182],"intramuscular":[62],"glycerol":[65,95],"hind":[68],"limbs":[69],"male":[71],"Wistar":[72],"rats.":[73,130,144,240],"(0.25":[75],"mg/kg/shot)":[76],"vehicle":[78],"administered":[80],"intravenously":[81],"1":[82],"h":[83,93],"before":[84],"1,":[86],"3,":[87],"5,":[88],"8,":[89],"24":[90],"36":[92],"after":[94],"injection.":[96],"Biochemical":[97],"parameters":[98,174],"for":[99],"serum":[100],"urine":[102],"were":[103,111],"measured":[104],"histological":[106],"analyses":[107,158],"kidneys":[110,126],"performed.":[112],"also":[114,175],"analyzed":[115],"endogenous":[116,208],"expression":[118],"phosphorylation":[120,190],"c-Met/HGF":[122,193,218],"receptor":[123,194,219],"RESULTS:":[131],"treatment":[133,162],"caused":[134,153],"invariably":[138],"led":[139],"death":[141,152],"Repeated":[145],"administration":[146,186],"protected":[149],"from":[151],"ARF.":[156],"Histological":[157],"revealed":[159],"that":[160,177,225],"reduced":[163],"necrosis":[164],"cells":[167],"cortex.":[171],"Serum/urine":[172],"biochemical":[173],"showed":[176],"dysfunction":[179],"improved":[181,235],"administration.":[184],"Intravenous":[185],"enhanced":[189],"mitogen-activated":[196],"protein":[197],"kinase":[198],"kidney.":[201],"In":[202],"vehicle-treated":[204],"group":[205],"concentration":[210],"decreased":[211],"there":[213],"no":[215],"change":[216],"phosphorylation.":[220],"CONCLUSION:":[221],"These":[222],"results":[223],"indicate":[224],"effectively":[227],"accelerated":[228],"recovery":[230],"function":[233],"survival":[236]},"counts_by_year":[{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}