{"id":"https://openalex.org/W2048643605","doi":"https://doi.org/10.1016/s1556-0864(15)31599-9","title":"EGFR: A Prognostic and/or a Predictive Marker?","display_name":"EGFR: A Prognostic and/or a Predictive Marker?","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W2048643605","doi":"https://doi.org/10.1016/s1556-0864(15)31599-9","mag":"2048643605","pmid":"https://pubmed.ncbi.nlm.nih.gov/17409888"},"language":"en","primary_location":{"id":"doi:10.1016/s1556-0864(15)31599-9","doi":"https://doi.org/10.1016/s1556-0864(15)31599-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1556-0864(15)31599-9","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/s1556-0864(15)31599-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071851332","display_name":"Fred R. Hirsch","orcid":"https://orcid.org/0000-0002-6885-1894","observed_orcids":["https://orcid.org/0000-0002-6885-1894"]},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fred R. Hirsch","raw_affiliation_strings":["Departments of Medicine/Medical Oncology and Pathology, University of Colorado Cancer Center, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine/Medical Oncology and Pathology, University of Colorado Cancer Center, Aurora, CO","institution_ids":["https://openalex.org/I4210134151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071851332"],"corresponding_institution_ids":["https://openalex.org/I4210134151"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":1.0577,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.80012633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"5","first_page":"395","last_page":"397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.08879999816417694,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.902999997138977},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8429999947547913},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9160000085830688},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":1.0},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9789999723434448},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9393153190612793},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.809123158454895},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5348649621009827},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.4793615937232971},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46335864067077637},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.45277175307273865},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0973973274230957}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018900","descriptor_name":"Dinucleotide Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1556-0864(15)31599-9","doi":"https://doi.org/10.1016/s1556-0864(15)31599-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1556-0864(15)31599-9","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},{"id":"doi:10.1097/01243894-200606000-00001","doi":"https://doi.org/10.1097/01243894-200606000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01243894-200606000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},{"id":"pmid:17409888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17409888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1016/s1556-0864(15)31599-9","doi":"https://doi.org/10.1016/s1556-0864(15)31599-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1556-0864(15)31599-9","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1479896379","https://openalex.org/W1570974013","https://openalex.org/W1937846560","https://openalex.org/W1970476748","https://openalex.org/W1988442083","https://openalex.org/W2043696829","https://openalex.org/W2049484790","https://openalex.org/W2057316534","https://openalex.org/W2071551577","https://openalex.org/W2086971982","https://openalex.org/W2098076634","https://openalex.org/W2101055110","https://openalex.org/W2114060414","https://openalex.org/W2120718661","https://openalex.org/W2127101185","https://openalex.org/W2138297714","https://openalex.org/W2138604360","https://openalex.org/W2141393790","https://openalex.org/W2142564546","https://openalex.org/W2142850084","https://openalex.org/W2143859186","https://openalex.org/W2155384808","https://openalex.org/W2160866033","https://openalex.org/W2161821474","https://openalex.org/W2162724777","https://openalex.org/W2168554121","https://openalex.org/W2171152917","https://openalex.org/W2229637481","https://openalex.org/W2297901492","https://openalex.org/W2315493012"],"related_works":["https://openalex.org/W2411643622","https://openalex.org/W6996380229","https://openalex.org/W2061652685","https://openalex.org/W2046308569","https://openalex.org/W2120208580","https://openalex.org/W2011026203","https://openalex.org/W2026836017","https://openalex.org/W1973988862","https://openalex.org/W2168334299","https://openalex.org/W2145580674"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}