{"id":"https://openalex.org/W2048635834","doi":"https://doi.org/10.1046/j.1365-3156.2003.01025.x","title":"Tuberculosis treatment in complex emergencies: are risks outweighing benefits?","display_name":"Tuberculosis treatment in complex emergencies: are risks outweighing benefits?","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2048635834","doi":"https://doi.org/10.1046/j.1365-3156.2003.01025.x","mag":"2048635834","pmid":"https://pubmed.ncbi.nlm.nih.gov/12631310"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-3156.2003.01025.x","doi":"https://doi.org/10.1046/j.1365-3156.2003.01025.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-3156.2003.01025.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-3156.2003.01025.x","source":{"id":"https://openalex.org/S148484591","display_name":"Tropical Medicine & International Health","issn_l":"1360-2276","issn":["1360-2276","1365-3156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Medicine &amp; International Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-3156.2003.01025.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021248790","display_name":"Marc Biot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Biot","raw_affiliation_strings":["marcisa.biot@swing.be","Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"marcisa.biot@swing.be","institution_ids":[]},{"raw_affiliation_string":"Brussels, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026726987","display_name":"Daniel Chandramohan","orcid":"https://orcid.org/0000-0002-6974-5620","observed_orcids":["https://orcid.org/0000-0002-6974-5620"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Chandramohan","raw_affiliation_strings":["London School of Hygiene and Tropical Medicine, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London School of Hygiene and Tropical Medicine, UK","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"last","author":{"id":null,"display_name":"J. D. H. Porter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. D. H. Porter","raw_affiliation_strings":["London School of Hygiene and Tropical Medicine, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London School of Hygiene and Tropical Medicine, UK","institution_ids":["https://openalex.org/I4210089966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.1941,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.61589803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"3","first_page":"211","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14090","display_name":"Health and Conflict Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13586","display_name":"HIV, TB, and STIs Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3300","display_name":"General Social Sciences"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.8870000243186951},{"id":"https://openalex.org/keywords/complex-humanitarian-emergencies","display_name":"complex emergencies","score":0.996999979019165},{"id":"https://openalex.org/keywords/humanitarian-settings","display_name":"humanitarian settings","score":0.5960000157356262},{"id":"https://openalex.org/keywords/treatment-guidelines","display_name":"treatment guidelines","score":0.5720000267028809},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6769999861717224},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.4580000042915344},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7726335525512695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7072633504867554},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.6602314114570618},{"id":"https://openalex.org/C2777363581","wikidata":"https://www.wikidata.org/wiki/Q15098235","display_name":"Harm","level":2,"score":0.6083325147628784},{"id":"https://openalex.org/C3019056677","wikidata":"https://www.wikidata.org/wiki/Q1189184","display_name":"Tb treatment","level":3,"score":0.4845384955406189},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.45411232113838196},{"id":"https://openalex.org/C127454912","wikidata":"https://www.wikidata.org/wiki/Q942582","display_name":"Cost\u2013benefit analysis","level":2,"score":0.4184833765029907},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.41738465428352356},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3927163779735565},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.11343640089035034},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.1013195812702179},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08566698431968689},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004630","descriptor_name":"Emergencies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010349","descriptor_name":"Patient Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011634","descriptor_name":"Public Health","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D012066","descriptor_name":"Relief Work","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D014857","descriptor_name":"Warfare","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015397","descriptor_name":"Program Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1046/j.1365-3156.2003.01025.x","doi":"https://doi.org/10.1046/j.1365-3156.2003.01025.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-3156.2003.01025.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-3156.2003.01025.x","source":{"id":"https://openalex.org/S148484591","display_name":"Tropical Medicine & International Health","issn_l":"1360-2276","issn":["1360-2276","1365-3156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Medicine &amp; International Health","raw_type":"journal-article"},{"id":"pmid:12631310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12631310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical medicine & international health : TM & IH","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.521.42","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.521.42","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://fieldresearch.msf.org/msf/bitstream/10144/39578/1/Biot Math Model.pdf","raw_type":"text"},{"id":"pmh:oai:fieldresearch.msf.org:10144/39578","doi":null,"is_oa":false,"landing_page_url":"http://fieldresearch.msf.org/msf/handle/10144/39578","pdf_url":null,"source":{"id":"https://openalex.org/S4306402090","display_name":"Medecins Sans Frontieres Field Research (Medecins Sans Frontieres)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210128224","host_organization_name":"M\u00e9decins Sans Fronti\u00e8res","host_organization_lineage":["https://openalex.org/I4210128224"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1046/j.1365-3156.2003.01025.x","doi":"https://doi.org/10.1046/j.1365-3156.2003.01025.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-3156.2003.01025.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-3156.2003.01025.x","source":{"id":"https://openalex.org/S148484591","display_name":"Tropical Medicine & International Health","issn_l":"1360-2276","issn":["1360-2276","1365-3156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Medicine &amp; International Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311430","display_name":"London School of Hygiene and Tropical Medicine","ror":"https://ror.org/00a0jsq62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2048635834.pdf","grobid_xml":"https://content.openalex.org/works/W2048635834.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W114187538","https://openalex.org/W116308367","https://openalex.org/W157589880","https://openalex.org/W655573348","https://openalex.org/W1594955627","https://openalex.org/W1971547696","https://openalex.org/W1977033353","https://openalex.org/W1984852290","https://openalex.org/W1993045306","https://openalex.org/W2002775590","https://openalex.org/W2010364452","https://openalex.org/W2025134312","https://openalex.org/W2031671348","https://openalex.org/W2037513566","https://openalex.org/W2065705468","https://openalex.org/W2072432025","https://openalex.org/W2131871259","https://openalex.org/W2139602507","https://openalex.org/W2145712643","https://openalex.org/W2147499656","https://openalex.org/W2151923407","https://openalex.org/W2280457616","https://openalex.org/W2409073090","https://openalex.org/W2413822258","https://openalex.org/W2416817366","https://openalex.org/W2621326298","https://openalex.org/W3146047146","https://openalex.org/W3204967580","https://openalex.org/W4236653558","https://openalex.org/W4238748109","https://openalex.org/W4239012015","https://openalex.org/W4243167694","https://openalex.org/W4243778166","https://openalex.org/W4244096444","https://openalex.org/W4247065054","https://openalex.org/W4300580349"],"related_works":["https://openalex.org/W2765969175","https://openalex.org/W2616101608","https://openalex.org/W2614987212","https://openalex.org/W2015066769","https://openalex.org/W2107919614","https://openalex.org/W2597102331","https://openalex.org/W7167212409","https://openalex.org/W4388011977","https://openalex.org/W2148282251","https://openalex.org/W4211180220"],"abstract_inverted_index":{"Tuberculosis":[0],"(TB)":[1],"is":[2,57],"a":[3,78,90,112],"major":[4],"public":[5,133,158],"health":[6,159],"problem":[7,35],"in":[8,39,89,104,130],"complex":[9,109],"emergencies.":[10],"Humanitarian":[11],"agencies":[12],"usually":[13],"postpone":[14],"the":[15,34,61,87,93,102,137,157,164],"decision":[16],"to":[17,23,59,77,154],"offer":[18,116],"TB":[19,25,113,165],"treatment":[20,38,45,67,106,118,147],"and":[21,42,63,99,101,161],"opportunities":[22],"treat":[24],"patients":[26,140],"are":[27,75],"often":[28],"missed.":[29],"This":[30],"paper":[31],"looks":[32],"at":[33,142],"of":[36,65,96,121,132,139,146,163],"tuberculosis":[37],"these":[40],"emergencies":[41],"questions":[43],"whether":[44],"guidelines":[46],"could":[47,115,125],"be":[48,127,149],"more":[49],"flexible":[50],"than":[51],"international":[52],"recommendations.":[53],"A":[54],"mathematical":[55],"model":[56],"used":[58,150],"calculate":[60],"risks":[62],"benefits":[64],"different":[66],"scenarios":[68],"with":[69],"increasing":[70],"default":[71],"rates.":[72],"Model":[73],"outcomes":[74],"compared":[76],"situation":[79],"without":[80],"treatment.":[81],"An":[82],"economic":[83],"analysis":[84],"further":[85],"discusses":[86],"findings":[88],"trade-off":[91],"between":[92],"extra":[94],"costs":[95],"treating":[97],"relapses":[98],"failures":[100],"savings":[103],"future":[105],"costs.":[107],"In":[108,135],"emergencies,":[110],"if":[111],"programme":[114],"4-month":[117],"for":[119],"75%":[120],"its":[122],"patients,":[123],"it":[124],"still":[126],"considered":[128],"beneficial":[129],"terms":[131],"health.":[134],"addition,":[136],"proportion":[138],"following":[141],"least":[143],"4":[144],"months":[145],"can":[148],"as":[151],"an":[152],"indicator":[153],"help":[155],"evaluate":[156],"harm":[160],"benefit":[162],"programme.":[166]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
