{"id":"https://openalex.org/W2048633347","doi":"https://doi.org/10.1016/0003-9861(85)90820-3","title":"3-Methylcholanthrene-induced expression of the cytochrome P-450c gene","display_name":"3-Methylcholanthrene-induced expression of the cytochrome P-450c gene","publication_year":1985,"publication_date":"1985-05-01","ids":{"openalex":"https://openalex.org/W2048633347","doi":"https://doi.org/10.1016/0003-9861(85)90820-3","mag":"2048633347","pmid":"https://pubmed.ncbi.nlm.nih.gov/4004253"},"language":"en","primary_location":{"id":"doi:10.1016/0003-9861(85)90820-3","doi":"https://doi.org/10.1016/0003-9861(85)90820-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-9861(85)90820-3","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049927188","display_name":"Robert L. Foldes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert L. Foldes","raw_affiliation_strings":["The Department of Pharmacology University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pharmacology University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055852244","display_name":"Ronald N. Hines","orcid":"https://orcid.org/0000-0002-3094-4200","observed_orcids":["https://orcid.org/0000-0002-3094-4200"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald N. Hines","raw_affiliation_strings":["The Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038643724","display_name":"Kai-Ling Ho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai-Ling Ho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111748864","display_name":"Mei-Ling Shen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei-Ling Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023724531","display_name":"Keith B. Nagel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith B. Nagel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000727984","display_name":"Edward Bresnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Bresnick","raw_affiliation_strings":["Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA","The Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA","The Department of Pharmacology University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"The Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"The Department of Pharmacology University of Nebraska Medical Center, Omaha, Nebraska, 68105 USA","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049927188"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":3.184,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.92345183,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"239","issue":"1","first_page":"137","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3-methylcholanthrene","display_name":"3-methylcholanthrene","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cytochrome-p-450c","display_name":"cytochrome P-450c","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.5239999890327454},{"id":"https://openalex.org/keywords/nuclear-rna","display_name":"nuclear RNA","score":0.45100000500679016},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.5350000262260437},{"id":"https://openalex.org/keywords/hepatic-nuclei","display_name":"hepatic nuclei","score":0.5320000052452087},{"id":"https://openalex.org/keywords/mrna-induction","display_name":"mRNA induction","score":0.515999972820282},{"id":"https://openalex.org/keywords/polyadenylation","display_name":"polyadenylation","score":0.625},{"id":"https://openalex.org/keywords/introns","display_name":"introns","score":0.5249999761581421},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.7960000038146973},{"id":"https://openalex.org/keywords/precursor-mrna","display_name":"mRNA precursors","score":0.40299999713897705},{"id":"https://openalex.org/keywords/in-vitro-transcription","display_name":"in vitro transcription","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2780303067","wikidata":"https://www.wikidata.org/wiki/Q223099","display_name":"Methylcholanthrene","level":3,"score":0.7500056028366089},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.5190242528915405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4889031946659088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4467403292655945},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.437283456325531},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42255860567092896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37321147322654724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3516504168510437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28774553537368774},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.14210104942321777},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0668419897556305}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008748","descriptor_name":"Methylcholanthrene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0003-9861(85)90820-3","doi":"https://doi.org/10.1016/0003-9861(85)90820-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-9861(85)90820-3","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:4004253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4004253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2211743046","display_name":null,"funder_award_id":"ES-03304","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2487883305","display_name":null,"funder_award_id":"ES-03304","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W233730272","https://openalex.org/W629757765","https://openalex.org/W647501213","https://openalex.org/W1486647359","https://openalex.org/W1501688570","https://openalex.org/W1512266787","https://openalex.org/W1532668225","https://openalex.org/W1551458838","https://openalex.org/W1558770975","https://openalex.org/W1562512611","https://openalex.org/W1563025751","https://openalex.org/W1597931093","https://openalex.org/W1598530978","https://openalex.org/W1862128096","https://openalex.org/W1965750059","https://openalex.org/W1972760299","https://openalex.org/W1973458805","https://openalex.org/W1994158911","https://openalex.org/W1997137408","https://openalex.org/W1997508004","https://openalex.org/W1999260436","https://openalex.org/W2003420525","https://openalex.org/W2005063559","https://openalex.org/W2005672080","https://openalex.org/W2006506558","https://openalex.org/W2007151377","https://openalex.org/W2021291137","https://openalex.org/W2024814032","https://openalex.org/W2027146260","https://openalex.org/W2029167148","https://openalex.org/W2029987769","https://openalex.org/W2054158586","https://openalex.org/W2054468433","https://openalex.org/W2055889835","https://openalex.org/W2056391548","https://openalex.org/W2058534626","https://openalex.org/W2060333964","https://openalex.org/W2064419581","https://openalex.org/W2064456217","https://openalex.org/W2078436276","https://openalex.org/W2081034153","https://openalex.org/W2088554998","https://openalex.org/W2093935549","https://openalex.org/W2095488937","https://openalex.org/W2111597989","https://openalex.org/W2112840494","https://openalex.org/W2136482187","https://openalex.org/W2171557581","https://openalex.org/W2277483343","https://openalex.org/W2342230255","https://openalex.org/W2419094179","https://openalex.org/W2420483227","https://openalex.org/W2437830317"],"related_works":["https://openalex.org/W2055889835","https://openalex.org/W2029167148","https://openalex.org/W2077334866","https://openalex.org/W1504512890","https://openalex.org/W2270348962","https://openalex.org/W4214682237","https://openalex.org/W2130838792","https://openalex.org/W1546506807","https://openalex.org/W1486647359","https://openalex.org/W2154333090"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
