{"id":"https://openalex.org/W2048604010","doi":"https://doi.org/10.1016/j.etp.2008.04.016","title":"Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats","display_name":"Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats","publication_year":2008,"publication_date":"2008-08-06","ids":{"openalex":"https://openalex.org/W2048604010","doi":"https://doi.org/10.1016/j.etp.2008.04.016","mag":"2048604010","pmid":"https://pubmed.ncbi.nlm.nih.gov/18684602"},"language":"en","primary_location":{"id":"doi:10.1016/j.etp.2008.04.016","doi":"https://doi.org/10.1016/j.etp.2008.04.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etp.2008.04.016","pdf_url":null,"source":{"id":"https://openalex.org/S93526581","display_name":"Experimental and Toxicologic Pathology","issn_l":"0940-2993","issn":["0940-2993","1618-1433"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024568691","display_name":"Suna Atasayar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S. Atasayar","raw_affiliation_strings":["Department of Toxicology, Hacettepe University, Sihhiye, Ankara, Turkey","Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 Sihhiye-, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Hacettepe University, Sihhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 Sihhiye-, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046696950","display_name":"Hande G\u00fcrer-Orhan","orcid":"https://orcid.org/0000-0002-4890-299X","observed_orcids":["https://orcid.org/0000-0002-4890-299X"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H. G\u00fcrer-Orhan","raw_affiliation_strings":["Department of Toxicology, Ege University, Faculty of Pharmacy, \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Ege University, Faculty of Pharmacy, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003157478","display_name":"Hi\u0307lmi\u0307 Orhan","orcid":"https://orcid.org/0000-0003-2464-1841","observed_orcids":["https://orcid.org/0000-0003-2464-1841"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H. Orhan","raw_affiliation_strings":["Department of Toxicology, Ege University, Faculty of Pharmacy, \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Ege University, Faculty of Pharmacy, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019797870","display_name":"Bora G\u00fcrel","orcid":"https://orcid.org/0000-0002-5018-8078","observed_orcids":["https://orcid.org/0000-0002-5018-8078","https://orcid.org/0000-0002-5887-6924"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"B. G\u00fcrel","raw_affiliation_strings":["Faculty of Medicine, Department of Pathology, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Pathology, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061998188","display_name":"G\u00f6zde Girgin","orcid":"https://orcid.org/0000-0002-7051-0490","observed_orcids":["https://orcid.org/0000-0002-7051-0490"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G. Girgin","raw_affiliation_strings":["Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 S\u0131hhiye, Ankara, Turkey","Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 Sihhiye-, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 S\u0131hhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 Sihhiye-, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025646957","display_name":"Hil\u00e2l \u00d6zg\u00fcne\u015f","orcid":"https://orcid.org/0000-0002-5561-3491","observed_orcids":["https://orcid.org/0000-0002-5561-3491"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"H. \u00d6zg\u00fcne\u015f","raw_affiliation_strings":["Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 S\u0131hhiye, Ankara, Turkey","Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 Sihhiye-, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 S\u0131hhiye, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100 Sihhiye-, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025646957"],"corresponding_institution_ids":["https://openalex.org/I66514158"],"apc_list":null,"apc_paid":null,"fwci":2.601,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.88744249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"61","issue":"1","first_page":"23","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoguanidine","display_name":"aminoguanidine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cisplatin-induced-nephrotoxicity","display_name":"cisplatin nephrotoxicity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.8220000267028809},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6209999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9629999995231628},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.6850000023841858},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9909999966621399},{"id":"https://openalex.org/keywords/renal-tubular-injury","display_name":"renal tubular injury","score":0.8859999775886536},{"id":"https://openalex.org/keywords/perivascular-inflammation","display_name":"perivascular inflammation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/serum-creatinine-and-urea","display_name":"serum urea and creatinine","score":0.8849999904632568},{"id":"https://openalex.org/keywords/liver-glutathione","display_name":"liver glutathione","score":0.6069999933242798},{"id":"https://openalex.org/keywords/drug-induced-nephrotoxicity","display_name":"drug-induced nephrotoxicity","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.9092283844947815},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.8231683969497681},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.776075541973114},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.6979751586914062},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6055487394332886},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5991649627685547},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.576996386051178},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.568831741809845},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5449158549308777},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.5073975920677185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49088913202285767},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48163288831710815},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.44997721910476685},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41227641701698303},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3088938295841217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2812398076057434},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.12745314836502075},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.050991714000701904}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.etp.2008.04.016","doi":"https://doi.org/10.1016/j.etp.2008.04.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etp.2008.04.016","pdf_url":null,"source":{"id":"https://openalex.org/S93526581","display_name":"Experimental and Toxicologic Pathology","issn_l":"0940-2993","issn":["0940-2993","1618-1433"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:18684602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18684602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323272","display_name":"Hacettepe \u00dcniversitesi","ror":"https://ror.org/04kwvgz42"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W91109734","https://openalex.org/W1551392207","https://openalex.org/W1967094642","https://openalex.org/W1970933571","https://openalex.org/W1981653365","https://openalex.org/W1985021708","https://openalex.org/W1986408454","https://openalex.org/W1991352662","https://openalex.org/W1996542153","https://openalex.org/W2002337501","https://openalex.org/W2004242660","https://openalex.org/W2005177023","https://openalex.org/W2005998580","https://openalex.org/W2007543485","https://openalex.org/W2007996849","https://openalex.org/W2008741015","https://openalex.org/W2010094123","https://openalex.org/W2020003158","https://openalex.org/W2023020232","https://openalex.org/W2027737927","https://openalex.org/W2028629615","https://openalex.org/W2032082822","https://openalex.org/W2032980304","https://openalex.org/W2036940703","https://openalex.org/W2041293207","https://openalex.org/W2052304690","https://openalex.org/W2056567773","https://openalex.org/W2062115472","https://openalex.org/W2065741201","https://openalex.org/W2065906579","https://openalex.org/W2071438280","https://openalex.org/W2079736357","https://openalex.org/W2087690555","https://openalex.org/W2092954078","https://openalex.org/W2109276608","https://openalex.org/W2114640031","https://openalex.org/W2116749308","https://openalex.org/W2121394574","https://openalex.org/W2121852212","https://openalex.org/W2123668146","https://openalex.org/W2131237241","https://openalex.org/W2131843660","https://openalex.org/W2159098534","https://openalex.org/W2159758267","https://openalex.org/W2168807041"],"related_works":["https://openalex.org/W7208718980","https://openalex.org/W2121852212","https://openalex.org/W2003572460","https://openalex.org/W2945484052","https://openalex.org/W2725666753","https://openalex.org/W2109276608","https://openalex.org/W2743336850","https://openalex.org/W3033426919","https://openalex.org/W2927047920","https://openalex.org/W2514222938"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}