{"id":"https://openalex.org/W2048565177","doi":"https://doi.org/10.1084/jem.187.8.1285","title":"Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon \u03b3 and Inhibits Tumor Necrosis Factor \u03b1\u2013induced IL-8 Release","display_name":"Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon \u03b3 and Inhibits Tumor Necrosis Factor \u03b1\u2013induced IL-8 Release","publication_year":1998,"publication_date":"1998-04-20","ids":{"openalex":"https://openalex.org/W2048565177","doi":"https://doi.org/10.1084/jem.187.8.1285","mag":"2048565177","pmid":"https://pubmed.ncbi.nlm.nih.gov/9547339","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2212233"},"language":"en","primary_location":{"id":"doi:10.1084/jem.187.8.1285","doi":"https://doi.org/10.1084/jem.187.8.1285","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.187.8.1285","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2212233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068549832","display_name":"Karsten Gronert","orcid":"https://orcid.org/0000-0002-5329-7907","observed_orcids":["https://orcid.org/0000-0002-5329-7907"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karsten Gronert","raw_affiliation_strings":["From the *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, and the \u2021Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, and the \u2021Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019350885","display_name":"Andrew T. Gewirtz","orcid":"https://orcid.org/0000-0002-6338-7578","observed_orcids":["https://orcid.org/0000-0002-6338-7578"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Gewirtz","raw_affiliation_strings":["From the *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, and the \u2021Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, and the \u2021Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109841136","display_name":"James Madara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Madara","raw_affiliation_strings":["From the *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, and the \u2021Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, and the \u2021Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles N. Serhan","raw_affiliation_strings":["From the *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, and the \u2021Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, and the \u2021Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.7277,"has_fulltext":false,"cited_by_count":207,"citation_normalized_percentile":{"value":0.98244048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"187","issue":"8","first_page":"1285","last_page":"1294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoxin-a4-receptor","display_name":"lipoxin A4 receptor","score":0.9120000004768372},{"id":"https://openalex.org/keywords/enterocytes","display_name":"enterocytes","score":0.8939999938011169},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9449999928474426},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/il-8-release","display_name":"IL-8 release","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8149999976158142},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9300000071525574},{"id":"https://openalex.org/keywords/15-epi-lipoxin-a4","display_name":"15-epi-lipoxin A4","score":0.8740000128746033},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.6150000095367432},{"id":"https://openalex.org/keywords/mucosal-barrier-function","display_name":"mucosal barrier function","score":0.7490000128746033},{"id":"https://openalex.org/keywords/chloride-secretion","display_name":"chloride secretion","score":0.6389999985694885},{"id":"https://openalex.org/keywords/anti-inflammatory-signaling","display_name":"anti-inflammatory signaling","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2779604457","wikidata":"https://www.wikidata.org/wiki/Q1340349","display_name":"Enterocyte","level":3,"score":0.8078352212905884},{"id":"https://openalex.org/C2780415110","wikidata":"https://www.wikidata.org/wiki/Q4329","display_name":"Lipoxin","level":3,"score":0.7459245324134827},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.50809645652771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48999205231666565},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4711301028728485},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4413691759109497},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4348810315132141},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38244253396987915},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3559880554676056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29261961579322815},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26985442638397217},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24832960963249207},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.10378903150558472}],"mesh":[{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044042","descriptor_name":"Receptors, Formyl Peptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044045","descriptor_name":"Lipoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044067","descriptor_name":"Receptors, Lipoxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.187.8.1285","doi":"https://doi.org/10.1084/jem.187.8.1285","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.187.8.1285","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2212233","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2212233","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:9547339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9547339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.283.3395","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.283.3395","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/66/88/J_Exp_Med_1998_Apr_20_187(8)_1285-1294.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.335.887","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.887","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jem.rupress.org/content/187/8/1285.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2212233","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2212233","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2019571594","display_name":"BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTION","funder_award_id":"4r37gm038765-19","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G301977313","display_name":null,"funder_award_id":"GM 38765","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4512190805","display_name":null,"funder_award_id":"DK-35392","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6935072096","display_name":"Blood Cell Lipoxygenase Products -- Formation and Action","funder_award_id":"R01GM038765","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G712140867","display_name":null,"funder_award_id":"R37-GM038765","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7979141929","display_name":"Epithelial-Neutrophil Interactions in IBD","funder_award_id":"R01DK047662","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W12110462","https://openalex.org/W140981747","https://openalex.org/W162223277","https://openalex.org/W1484553440","https://openalex.org/W1521799099","https://openalex.org/W1542190151","https://openalex.org/W1582077381","https://openalex.org/W1601254282","https://openalex.org/W1640538369","https://openalex.org/W1640670825","https://openalex.org/W1648593433","https://openalex.org/W1672565987","https://openalex.org/W1869980306","https://openalex.org/W1964942556","https://openalex.org/W1968219794","https://openalex.org/W1977194082","https://openalex.org/W1979417079","https://openalex.org/W1986483382","https://openalex.org/W2010528809","https://openalex.org/W2011568956","https://openalex.org/W2013643526","https://openalex.org/W2019359180","https://openalex.org/W2021905899","https://openalex.org/W2024065712","https://openalex.org/W2026499711","https://openalex.org/W2037697142","https://openalex.org/W2040711587","https://openalex.org/W2048234380","https://openalex.org/W2049385249","https://openalex.org/W2050693247","https://openalex.org/W2054044627","https://openalex.org/W2057625875","https://openalex.org/W2059429399","https://openalex.org/W2065376096","https://openalex.org/W2071201771","https://openalex.org/W2080378803","https://openalex.org/W2085801558","https://openalex.org/W2089923844","https://openalex.org/W2133035274","https://openalex.org/W2145969791","https://openalex.org/W2150571795","https://openalex.org/W2155474314","https://openalex.org/W2162382352","https://openalex.org/W2412067085","https://openalex.org/W2415195951","https://openalex.org/W2576734941","https://openalex.org/W6606571740"],"related_works":["https://openalex.org/W7095590151","https://openalex.org/W2162569098","https://openalex.org/W1992431604","https://openalex.org/W2012967151","https://openalex.org/W2099788086","https://openalex.org/W7096892234","https://openalex.org/W2130939935","https://openalex.org/W2164273883","https://openalex.org/W2178216880","https://openalex.org/W2163137314"],"abstract_inverted_index":{"Epithelial":[0],"cells":[1],"of":[2,31,60,67,150,205],"the":[3,76,148,168,214],"alimentary":[4],"tract":[5],"play":[6],"a":[7,45,151,203,233],"central":[8],"role":[9],"in":[10,132,137,194],"mucosal":[11,19,228],"immunophysiology.":[12],"Pathogens":[13],"and/or":[14],"agonists":[15],"that":[16,25,58,180],"interact":[17],"with":[18],"surfaces":[20],"often":[21],"elicit":[22],"epithelial":[23,36],"responses":[24],"upregulate":[26],"inflammation.":[27],"Therefore,":[28],"it":[29],"was":[30,63],"interest":[32],"to":[33],"explore":[34],"potential":[35,234],"targeted":[37],"antiinflammatory":[38],"signals.":[39],"Here":[40],"we":[41],"identified":[42],"and":[43,56,72,81,113,135,140,175,188,231],"sequenced":[44],"human":[46],"enterocyte":[47,88],"lipoxin":[48],"(LX)":[49],"A4":[50],"[5(S),":[51],"6(R),15(S)-trihydroxy-7,9,13-trans-11-cis":[52],"eicosatetraenoic":[53],"acid]":[54],"receptor,":[55],"demonstrate":[57],"transcription":[59],"this":[61],"receptor":[62,153],"controlled":[64],"by":[65,143,213],"cytokines,":[66],"which":[68],"lymphocyte-derived":[69],"interleukin":[70],"(IL)-13":[71],"interferon":[73],"gamma":[74],"were":[75,85,211],"most":[77],"potent.":[78],"When":[79],"lipoxins":[80,95],"LXA4":[82,152,238],"stable":[83,215,239],"analogs":[84],"evaluated":[86],"for":[87,173,226,237],"functional":[89],"as":[90,92,128,183,185],"well":[91,184],"immune":[93],"responses,":[94],"sharply":[96],"inhibited":[97],"TNF-alpha-induced":[98],"IL-8":[99,121],"release":[100],"but":[101],"did":[102],"not":[103],"alter":[104],"either":[105],"barrier":[106],"function":[107],"or":[108,165],"agonist-stimulated":[109],"chloride":[110],"secretion.":[111],"15R/S-methyl-LXA4":[112],"16-phenoxy-LXA4":[114],"each":[115],"attenuated":[116],"(IC50":[117],"approximately":[118],"10":[119],"nM)":[120],"release.":[122],"Cyclooxygenase":[123],"(COX)":[124],"II":[125,170,191],"is":[126],"emerging":[127],"an":[129,186,223],"important":[130],"component":[131],"wound":[133],"healing":[134],"proliferation":[136],"intestinal":[138],"epithelia":[139],"when":[141],"acetylated":[142],"acetylsalicylic":[144],"acid":[145],"(aspirin)":[146],"initiates":[147],"biosynthesis":[149],"ligand.":[154],"We":[155],"therefore":[156],"determined":[157],"whether":[158],"colonic":[159],"cell":[160],"lines":[161],"(HT-29":[162],"Cl.19A,":[163],"Caco-2,":[164],"T84)":[166],"express":[167],"COX":[169,181,190],"isozyme.":[171],"Results":[172],"RT-PCR":[174],"Western":[176],"blot":[177],"analysis":[178],"showed":[179],"I":[182],"IL-1beta-":[187],"TNF-alpha-inducible":[189],"are":[192],"expressed":[193],"HT-29":[195],"Cl.19A.":[196],"In":[197],"addition,":[198],"aspirin-treated":[199],"enterocytes":[200],"generated":[201],"15R-HETE,":[202],"precursor":[204],"15-epi-LXA4":[206],"biosynthesis,":[207],"whose":[208],"potent":[209],"bioactions":[210],"mimicked":[212],"analog":[216],"15R/S-methyl-LXA4.":[217],"Taken":[218],"together,":[219],"these":[220],"results":[221],"identify":[222],"endogenous":[224],"pathway":[225],"downregulating":[227],"inflammatory":[229],"events":[230],"suggest":[232],"therapeutic":[235],"benefit":[236],"analogs.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
