{"id":"https://openalex.org/W2048510089","doi":"https://doi.org/10.1117/12.585093","title":"Imaging cellular dynamics in vivo with multicolor fluorescent proteins","display_name":"Imaging cellular dynamics in vivo with multicolor fluorescent proteins","publication_year":2005,"publication_date":"2005-04-04","ids":{"openalex":"https://openalex.org/W2048510089","doi":"https://doi.org/10.1117/12.585093","mag":"2048510089"},"language":"en","primary_location":{"id":"doi:10.1117/12.585093","doi":"https://doi.org/10.1117/12.585093","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.585093","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["AntiCancer, Inc. (United States)","Univ. of California/San Diego (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc. (United States)","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Univ. of California/San Diego (United States)","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040819666"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19470699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5704","issue":null,"first_page":"146","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vivo-cell-imaging","display_name":"in vivo cell imaging","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dual-color-fluorescence-imaging","display_name":"dual-color fluorescence imaging","score":0.859000027179718},{"id":"https://openalex.org/keywords/red-fluorescent-protein","display_name":"red fluorescent protein","score":0.9729999899864197},{"id":"https://openalex.org/keywords/green-fluorescent-protein","display_name":"green fluorescent protein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/stromal-fibroblasts","display_name":"stromal fibroblasts","score":0.8930000066757202},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9559999704360962},{"id":"https://openalex.org/keywords/stem-cell-tracking","display_name":"stem cell tracking","score":0.9570000171661377},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.5540000200271606},{"id":"https://openalex.org/keywords/hair-follicle-stem-cells","display_name":"hair follicle stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.8259999752044678},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.7361180186271667},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6977505087852478},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.5244148969650269},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5162577629089355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.513256311416626},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.512803852558136},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46346157789230347},{"id":"https://openalex.org/C140051345","wikidata":"https://www.wikidata.org/wiki/Q7251501","display_name":"Protein subcellular localization prediction","level":3,"score":0.4480651617050171},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.42260491847991943},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09990721940994263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08327335119247437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08000746369361877}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.585093","doi":"https://doi.org/10.1117/12.585093","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.585093","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2170789568","https://openalex.org/W1595801582","https://openalex.org/W2145729112","https://openalex.org/W2013718088","https://openalex.org/W2169032395","https://openalex.org/W2508319946","https://openalex.org/W2047942864","https://openalex.org/W2578821662","https://openalex.org/W1992303404","https://openalex.org/W2410998230"],"abstract_inverted_index":{"The":[0],"new":[1,37],"field":[2],"of":[3,18,23,35,66,85,124,168,185,201],"in":[4,29,51,103,113,119,157,162,182,194,196,211,233],"vivo":[5,114,183,212],"cell":[6,38,94,172,186],"biology":[7,39],"is":[8,40,82],"being":[9],"developed":[10],"with":[11,61,87,115],"multi-colored":[12],"fluorescent":[13,19,46,53,116],"proteins.":[14,117],"With":[15],"the":[16,21,30,36,64,67,83,121,125,158,163,181],"use":[17],"proteins,":[20],"behavior":[22],"individual":[24],"cells":[25,86,106,140,154,178,202],"can":[26,99,107,132],"be":[27,100,109,133,208],"visualized":[28,102,110,210],"living":[31,197],"animal.":[32],"An":[33],"example":[34,81],"dual-color":[41],"fluorescence":[42],"imaging":[43,184],"using":[44],"red":[45],"protein":[47,54,220],"(RFP)-expressing":[48],"tumors":[49],"transplanted":[50],"green":[52],"(GFP)-expressing":[55],"transgenic":[56],"mice.":[57],"These":[58],"models":[59],"show":[60],"great":[62],"clarity":[63],"details":[65],"tumor-stroma":[68],"cell-cell":[69,214],"interaction":[70,98],"especially":[71],"tumor-induced":[72],"angiogenesis,":[73],"tumor-infiltrating":[74],"lymphocytes,":[75],"stromal":[76],"fibroblasts":[77],"and":[78,96,111,160,175,187,221,226],"macrophages.":[79],"Another":[80],"color-coding":[84],"RFP":[88,161],"or":[89],"GFP":[90,130,156],"such":[91],"that":[92],"both":[93],"types":[95],"their":[97,142],"simultaneously":[101,209],"vivo.":[104],"Stem":[105],"also":[108,179],"tracked":[112],"Mice,":[118],"which":[120],"regulatory":[122],"elements":[123],"stem-cell":[126],"marker":[127],"nestin":[128],"drive":[129],"expression,":[131,217],"used":[134],"to":[135,144,207],"visualize":[136],"hair":[137,146],"follicle":[138],"stem":[139],"including":[141,171,213],"ability":[143],"form":[145],"follicles":[147],"as":[148,150,190,192],"well":[149,191],"blood":[151],"vessels.":[152],"Dual-color":[153,177],"expressing":[155],"nucleus":[159],"cytoplasm":[164],"enable":[165,180,204],"real-time":[166],"visualization":[167],"nuclear-cytoplasm":[169],"dynamics":[170,225],"cycle":[173],"events":[174,206],"apoptosis.":[176],"nuclear":[188],"deformation":[189],"trafficking":[193],"capillaries":[195],"animals.":[198],"Multiple-color":[199],"labeling":[200],"will":[203],"multiple":[205],"interaction,":[215],"gene":[216],"ion":[218],"fluxes,":[219],"organelle":[222],"trafficking,":[223],"chromosome":[224],"numerous":[227],"other":[228],"processes":[229],"currently":[230],"still":[231],"studied":[232],"vitro.":[234]},"counts_by_year":[],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2016-06-24T00:00:00"}
