{"id":"https://openalex.org/W2048469845","doi":"https://doi.org/10.1074/jbc.m110.200139","title":"Dynamic Interdomain Interactions Contribute to the Inhibition of Matrix Metalloproteinases by Tissue Inhibitors of Metalloproteinases","display_name":"Dynamic Interdomain Interactions Contribute to the Inhibition of Matrix Metalloproteinases by Tissue Inhibitors of Metalloproteinases","publication_year":2011,"publication_date":"2011-04-26","ids":{"openalex":"https://openalex.org/W2048469845","doi":"https://doi.org/10.1074/jbc.m110.200139","mag":"2048469845","pmid":"https://pubmed.ncbi.nlm.nih.gov/21518756","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121501"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110.200139","doi":"https://doi.org/10.1074/jbc.m110.200139","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.200139","pdf_url":"http://www.jbc.org/article/S0021925819491631/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819491631/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042267819","display_name":"Albert G. Remacle","orcid":"https://orcid.org/0000-0003-1475-6346","observed_orcids":["https://orcid.org/0000-0003-1475-6346"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert G. Remacle","raw_affiliation_strings":["Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085936954","display_name":"Sergey A. Shiryaev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergey A. Shiryaev","raw_affiliation_strings":["Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","Sanford-Burnham-Prebys Medical Discovery Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Sanford-Burnham-Prebys Medical Discovery Institute","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032456513","display_name":"Ilian Radichev","orcid":"https://orcid.org/0000-0001-9585-8453","observed_orcids":["https://orcid.org/0000-0001-9585-8453"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilian A. Radichev","raw_affiliation_strings":["Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","Sanford-Burnham-Prebys Medical Discovery Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Sanford-Burnham-Prebys Medical Discovery Institute","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021997935","display_name":"Dmitri V. Rozanov","orcid":"https://orcid.org/0000-0001-9867-4596","observed_orcids":["https://orcid.org/0000-0001-9867-4596"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitri V. Rozanov","raw_affiliation_strings":["Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","Molecular & Medical Genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Molecular & Medical Genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084942532","display_name":"Boguslaw Stec","orcid":"https://orcid.org/0000-0002-8696-0349","observed_orcids":["https://orcid.org/0000-0002-8696-0349"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boguslaw Stec","raw_affiliation_strings":["Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","Sanford-Burnham-Prebys Medical Discovery Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Sanford-Burnham-Prebys Medical Discovery Institute","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013154347","display_name":"Alex Y. Strongin","orcid":"https://orcid.org/0000-0003-3765-3016","observed_orcids":["https://orcid.org/0000-0003-3765-3016"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alex Y. Strongin","raw_affiliation_strings":["Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","Sanford-Burnham-Prebys Medical Discovery Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Sanford-Burnham-Prebys Medical Discovery Institute","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013154347"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9788,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75735204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"286","issue":"23","first_page":"21002","last_page":"21012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.9929999709129333},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mt1-mmp","display_name":"MT1-MMP","score":0.824999988079071},{"id":"https://openalex.org/keywords/hemopexin-domain","display_name":"hemopexin domain","score":0.8679999709129333},{"id":"https://openalex.org/keywords/interdomain-interactions","display_name":"domain-domain interactions","score":0.7559999823570251},{"id":"https://openalex.org/keywords/steric-clashes","display_name":"steric clashes","score":0.6380000114440918},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.6840000152587891},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8993829488754272},{"id":"https://openalex.org/C2776474381","wikidata":"https://www.wikidata.org/wiki/Q409414","display_name":"Hemopexin","level":4,"score":0.7620254755020142},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.6295849084854126},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5585480332374573},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4956148862838745},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49319809675216675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4333818554878235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38374054431915283},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35864585638046265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31306055188179016},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25151485204696655},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1979025900363922},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1016245186328888},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m110.200139","doi":"https://doi.org/10.1074/jbc.m110.200139","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.200139","pdf_url":"http://www.jbc.org/article/S0021925819491631/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2377392","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121501","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3121501","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121501","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21518756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21518756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110.200139","doi":"https://doi.org/10.1074/jbc.m110.200139","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.200139","pdf_url":"http://www.jbc.org/article/S0021925819491631/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1762213146","display_name":"MT1-MMP pericellular proteolysis in malignancy","funder_award_id":"R01CA077470","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1884386682","display_name":null,"funder_award_id":"CA77470","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2568812009","display_name":null,"funder_award_id":"CA83017","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3414950272","display_name":"Metalloproteinases in tumor neovascularization","funder_award_id":"R01CA083017","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2048469845.pdf","grobid_xml":"https://content.openalex.org/works/W2048469845.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W148052990","https://openalex.org/W1501988955","https://openalex.org/W1649452503","https://openalex.org/W1928161708","https://openalex.org/W1971723451","https://openalex.org/W1975755455","https://openalex.org/W1976056601","https://openalex.org/W1977803215","https://openalex.org/W1979390430","https://openalex.org/W1982593288","https://openalex.org/W1983583471","https://openalex.org/W1985858578","https://openalex.org/W1986309446","https://openalex.org/W1992481780","https://openalex.org/W2000831618","https://openalex.org/W2002771508","https://openalex.org/W2003500892","https://openalex.org/W2004101410","https://openalex.org/W2010912389","https://openalex.org/W2012805799","https://openalex.org/W2013215928","https://openalex.org/W2023916307","https://openalex.org/W2026475713","https://openalex.org/W2026979911","https://openalex.org/W2035043633","https://openalex.org/W2037786647","https://openalex.org/W2040166170","https://openalex.org/W2042419096","https://openalex.org/W2043691312","https://openalex.org/W2045491115","https://openalex.org/W2047973155","https://openalex.org/W2049220062","https://openalex.org/W2050846830","https://openalex.org/W2052528675","https://openalex.org/W2056420432","https://openalex.org/W2059919196","https://openalex.org/W2060003849","https://openalex.org/W2062122607","https://openalex.org/W2063345899","https://openalex.org/W2063897047","https://openalex.org/W2064752762","https://openalex.org/W2064930914","https://openalex.org/W2068522981","https://openalex.org/W2068561314","https://openalex.org/W2068843202","https://openalex.org/W2069118847","https://openalex.org/W2071288353","https://openalex.org/W2081619019","https://openalex.org/W2087775449","https://openalex.org/W2088290460","https://openalex.org/W2089719502","https://openalex.org/W2091092639","https://openalex.org/W2092378032","https://openalex.org/W2106115645","https://openalex.org/W2110088633","https://openalex.org/W2115062156","https://openalex.org/W2135081762","https://openalex.org/W2146833615","https://openalex.org/W2151523705","https://openalex.org/W2151634828","https://openalex.org/W2154401382","https://openalex.org/W2155602568","https://openalex.org/W2208747862","https://openalex.org/W2506465085","https://openalex.org/W4250908540"],"related_works":["https://openalex.org/W2102991281","https://openalex.org/W2943221422","https://openalex.org/W1996962373","https://openalex.org/W4393138869","https://openalex.org/W70565427","https://openalex.org/W2414380262","https://openalex.org/W1965724404","https://openalex.org/W1981776699","https://openalex.org/W3165986481","https://openalex.org/W1980803553"],"abstract_inverted_index":{"Because":[0,118],"of":[1,19,60,93,98,104,119,148,166,175,201,221,224,242],"their":[2,233],"important":[3],"function,":[4],"matrix":[5],"metalloproteinases":[6],"(MMPs)":[7],"are":[8,33,56,65],"promising":[9],"drug":[10],"targets":[11],"in":[12,47,75,126,162,187,239],"multiple":[13],"diseases,":[14],"including":[15],"malignancies.":[16],"The":[17],"structure":[18],"MMPs":[20,49],"includes":[21],"a":[22,25,28,36,44,101,170,179],"catalytic":[23,110],"domain,":[24],"hinge,":[26],"and":[27,38,54,69,95,174,211],"hemopexin":[29],"domain":[30,92,111],"(PEX),":[31],"which":[32,163],"followed":[34],"by":[35,43,208],"transmembrane":[37],"cytoplasmic":[39],"tail":[40],"domains":[41,74,223],"or":[42],"glycosylphosphatidylinositol":[45],"linker":[46],"membrane-type":[48],"(MT-MMPs).":[50],"TIMPs-1,":[51],"-2,":[52],"-3,":[53],"-4":[55],"potent":[57],"natural":[58],"regulators":[59],"the":[61,66,70,89,96,105,109,149,158,164,184,188,194,197,202,218,237,243],"MMP":[62,246],"activity.":[63],"These":[64],"inhibitory":[67,150],"N-terminal":[68],"non-inhibitory":[71,90],"C-terminal":[72,91],"structural":[73,80,219],"TIMPs.":[76],"Based":[77],"on":[78],"our":[79,143,214],"modeling,":[81],"we":[82],"hypothesized":[83],"that":[84,217],"steric":[85],"clashes":[86],"exist":[87],"between":[88],"TIMPs":[94,225],"PEX":[97,106,165,186],"MMPs.":[99],"Conversely,":[100],"certain":[102],"mobility":[103],"relative":[107],"to":[108,114,141,227,235],"is":[112,131],"required":[113],"avoid":[115],"these":[116],"obstacles.":[117],"its":[120],"exceedingly":[121],"poor":[122],"association":[123],"constant":[124],"and,":[125],"contrast":[127,192],"with":[128,172,181,193,248],"TIMP-2,":[129],"TIMP-1":[130,210],"inefficient":[132],"against":[133],"MT1-MMP.":[134],"We":[135,156],"specifically":[136],"selected":[137],"an":[138],"MT1-MMP\u00b7TIMP-1":[139],"pair":[140],"test":[142],"hypothesis,":[144],"because":[145],"any":[146],"improvement":[147],"potency":[151],"would":[152],"be":[153,228],"readily":[154],"recorded.":[155],"characterized":[157],"domain-swapped":[159],"MT1-MMP":[160,189],"chimeras":[161,204],"MMP-2":[167],"(that":[168,177],"forms":[169,178],"complex":[171,180],"TIMP-2)":[173],"MMP-9":[176],"TIMP-1)":[182],"replaced":[183],"original":[185],"structure.":[190],"In":[191],"wild-type":[195],"MT1-MMP,":[196],"diverse":[198],"proteolytic":[199],"activities":[200],"swapped-PEX":[203],"were":[205],"then":[206],"inhibited":[207],"both":[209,222],"TIMP-2.":[212],"Overall,":[213],"studies":[215],"suggest":[216],"parameters":[220],"have":[226],"taken":[229],"into":[230],"account":[231],"for":[232],"re-engineering":[234],"harness":[236],"therapeutic":[238],"vivo":[240],"potential":[241],"novel":[244],"TIMP-based":[245],"antagonists":[247],"constrained":[249],"selectivity.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
