{"id":"https://openalex.org/W2048432018","doi":"https://doi.org/10.1186/1472-6882-11-105","title":"Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression","display_name":"Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression","publication_year":2011,"publication_date":"2011-11-03","ids":{"openalex":"https://openalex.org/W2048432018","doi":"https://doi.org/10.1186/1472-6882-11-105","mag":"2048432018","pmid":"https://pubmed.ncbi.nlm.nih.gov/22051322","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3231956"},"language":"en","primary_location":{"id":"doi:10.1186/1472-6882-11-105","doi":"https://doi.org/10.1186/1472-6882-11-105","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6882-11-105","pdf_url":"https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/1472-6882-11-105","source":{"id":"https://openalex.org/S163220592","display_name":"BMC Complementary and Alternative Medicine","issn_l":"1472-6882","issn":["1472-6882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/1472-6882-11-105","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001767449","display_name":"Joseph Schwager","orcid":"https://orcid.org/0000-0002-6174-6063","observed_orcids":["https://orcid.org/0000-0002-6174-6063"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph Schwager","raw_affiliation_strings":["DSM Nutritional Products Ltd, Department of Human Nutrition & Health, PO Box 2676, CH-4002 Basel, Switzerland. Joseph.Schwager@dsm.com","DSM Nutritional Products Ltd., Department of Human Nutrition and Health, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Nutritional Products Ltd, Department of Human Nutrition & Health, PO Box 2676, CH-4002 Basel, Switzerland. Joseph.Schwager@dsm.com","institution_ids":[]},{"raw_affiliation_string":"DSM Nutritional Products Ltd., Department of Human Nutrition and Health, Basel, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021853694","display_name":"Ulrich Hoeller","orcid":"https://orcid.org/0009-0004-8186-3429","observed_orcids":["https://orcid.org/0009-0004-8186-3429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrich Hoeller","raw_affiliation_strings":["DSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, CH-4002, Basel, Switzerland","DSM Nutritional Products Ltd., Department of Human Nutrition and Health, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, CH-4002, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"DSM Nutritional Products Ltd., Department of Human Nutrition and Health, Basel, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113554462","display_name":"Swen Wolfram","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Swen Wolfram","raw_affiliation_strings":["DSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, CH-4002, Basel, Switzerland","DSM Nutritional Products Ltd., Department of Human Nutrition and Health, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, CH-4002, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"DSM Nutritional Products Ltd., Department of Human Nutrition and Health, Basel, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077669688","display_name":"Nathalie Richard","orcid":"https://orcid.org/0000-0002-7091-6896","observed_orcids":["https://orcid.org/0000-0002-7091-6896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathalie Richard","raw_affiliation_strings":["DSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, CH-4002, Basel, Switzerland","DSM Nutritional Products Ltd., Department of Human Nutrition and Health, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, CH-4002, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"DSM Nutritional Products Ltd., Department of Human Nutrition and Health, Basel, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001767449"],"corresponding_institution_ids":[],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":2.6076,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.88392329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"105","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galactolipids","display_name":"galactolipids","score":0.9169999957084656},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/chondroprotection","display_name":"chondroprotection","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7049999833106995},{"id":"https://openalex.org/keywords/peripheral-blood-leukocytes","display_name":"peripheral blood leukocytes","score":0.824999988079071},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5820000171661377},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":1.0},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8199999928474426},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8320000171661377},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cartilage-catabolism","display_name":"cartilage catabolism","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.7362192869186401},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.686955451965332},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5465755462646484},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.516572117805481},{"id":"https://openalex.org/C116484652","wikidata":"https://www.wikidata.org/wiki/Q3492926","display_name":"CCL5","level":5,"score":0.508995771408081},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4975145161151886},{"id":"https://openalex.org/C2776157581","wikidata":"https://www.wikidata.org/wiki/Q4692239","display_name":"Aggrecanase","level":5,"score":0.4856351912021637},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4712885916233063},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.43382126092910767},{"id":"https://openalex.org/C2779783865","wikidata":"https://www.wikidata.org/wiki/Q410228","display_name":"Anandamide","level":5,"score":0.4299084544181824},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.4248467683792114},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42330506443977356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4007367789745331},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3746948540210724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29128575325012207},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.2890905737876892},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15816837549209595},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.14379215240478516},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14286869764328003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13691124320030212},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12111175060272217},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07985785603523254},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06507238745689392},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.0},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D027826","descriptor_name":"Rosa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D038983","descriptor_name":"Galactolipids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1472-6882-11-105","doi":"https://doi.org/10.1186/1472-6882-11-105","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6882-11-105","pdf_url":"https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/1472-6882-11-105","source":{"id":"https://openalex.org/S163220592","display_name":"BMC Complementary and Alternative Medicine","issn_l":"1472-6882","issn":["1472-6882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2239684","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3231956","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3231956","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3231956","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complement Altern Med","raw_type":"Text"},{"id":"pmid:22051322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22051322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC complementary and alternative medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.5611","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.5611","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/db/c2/BMC_Complement_Altern_Med_2011_Nov_3_11_105.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d13c64e256a94631a26776dbad7df117","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d13c64e256a94631a26776dbad7df117","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Complementary and Alternative Medicine, Vol 11, Iss 1, p 105 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1472-6882-11-105","doi":"https://doi.org/10.1186/1472-6882-11-105","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6882-11-105","pdf_url":"https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/1472-6882-11-105","source":{"id":"https://openalex.org/S163220592","display_name":"BMC Complementary and Alternative Medicine","issn_l":"1472-6882","issn":["1472-6882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337289","display_name":"DSM Nutritional Products","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2048432018.pdf","grobid_xml":"https://content.openalex.org/works/W2048432018.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1568585026","https://openalex.org/W1582431281","https://openalex.org/W1676185943","https://openalex.org/W1774678646","https://openalex.org/W1943190408","https://openalex.org/W1969721611","https://openalex.org/W1971290810","https://openalex.org/W1973050434","https://openalex.org/W1973344119","https://openalex.org/W1976133234","https://openalex.org/W1979972616","https://openalex.org/W1984248230","https://openalex.org/W1988011959","https://openalex.org/W1990324389","https://openalex.org/W1990844960","https://openalex.org/W1991040567","https://openalex.org/W1995246567","https://openalex.org/W1996739759","https://openalex.org/W1998544084","https://openalex.org/W1998866269","https://openalex.org/W2001358890","https://openalex.org/W2004065216","https://openalex.org/W2011928284","https://openalex.org/W2024890586","https://openalex.org/W2027304696","https://openalex.org/W2029322332","https://openalex.org/W2029355740","https://openalex.org/W2029784909","https://openalex.org/W2031236163","https://openalex.org/W2032962802","https://openalex.org/W2036123458","https://openalex.org/W2038236031","https://openalex.org/W2039113875","https://openalex.org/W2039799680","https://openalex.org/W2042245363","https://openalex.org/W2043302857","https://openalex.org/W2050310995","https://openalex.org/W2050959488","https://openalex.org/W2055291298","https://openalex.org/W2055340082","https://openalex.org/W2056242762","https://openalex.org/W2057491978","https://openalex.org/W2060021617","https://openalex.org/W2062522737","https://openalex.org/W2063580118","https://openalex.org/W2067694345","https://openalex.org/W2068775998","https://openalex.org/W2070408281","https://openalex.org/W2075735641","https://openalex.org/W2078575815","https://openalex.org/W2080801901","https://openalex.org/W2081050068","https://openalex.org/W2081577257","https://openalex.org/W2082273415","https://openalex.org/W2086199599","https://openalex.org/W2090113481","https://openalex.org/W2095085805","https://openalex.org/W2099603714","https://openalex.org/W2106171259","https://openalex.org/W2107210147","https://openalex.org/W2107396673","https://openalex.org/W2119108876","https://openalex.org/W2122751744","https://openalex.org/W2133633020","https://openalex.org/W2138960046","https://openalex.org/W2146051414","https://openalex.org/W2154476101","https://openalex.org/W2159382220","https://openalex.org/W2160989052","https://openalex.org/W2161277214","https://openalex.org/W2168119720","https://openalex.org/W2168649322","https://openalex.org/W2254082366","https://openalex.org/W2314791461"],"related_works":["https://openalex.org/W7099537916","https://openalex.org/W7100058317","https://openalex.org/W2068247846","https://openalex.org/W2007050109","https://openalex.org/W1992271013","https://openalex.org/W2944103344","https://openalex.org/W2082456059","https://openalex.org/W4224212787","https://openalex.org/W1995357836","https://openalex.org/W3187854771"],"abstract_inverted_index":{"BACKGROUND:":[0],"Clinical":[1],"studies":[2],"have":[3],"shown":[4,243],"that":[5,309],"rose":[6],"hip":[7],"powder":[8],"(RHP)":[9],"alleviates":[10],"osteoarthritis":[11,320],"(OA).":[12],"This":[13],"might":[14],"be":[15],"due":[16],"to":[17,41,52,151,157,168],"anti-inflammatory":[18],"and":[19,37,43,57,87,96,125,130,139,180,195,200,203,207,210,221,228,232,238,265,287,298,305,311,331],"cartilage-protective":[20],"properties":[21],"of":[22,29,60,164,190,214,248,269,275],"the":[23,54,92,126,188,212],"complete":[24],"RHP":[25,106,194,202,231,286,310],"or":[26,71,107,322],"specific":[27],"constituents":[28],"RHP.":[30,61,339],"Cellular":[31],"systems":[32,295],"(macrophages,":[33,296],"peripheral":[34,73],"blood":[35,74],"leukocytes":[36,75],"chondrocytes),":[38],"which":[39,277],"respond":[40],"inflammatory":[42,239,257,290],"OA-inducing":[44],"stimuli,":[45],"are":[46],"used":[47],"as":[48,242],"in":[49,68,153,161,184,292],"vitro":[50,154],"surrogates":[51],"evaluate":[53],"possible":[55],"pain-relief":[56],"disease-modifying":[58],"effects":[59,127,268,301],"METHODS:":[62],"(1)":[63],"Inflammatory":[64,79],"processes":[65,155,317],"were":[66,89,120,133,146,175,271],"induced":[67],"RAW264.7":[69],"cells":[70,138,227],"human":[72,141],"(PBL)":[76],"with":[77,148,319],"LPS.":[78],"mediators":[80],"(nitric":[81],"oxide":[82],"(NO),":[83],"prostaglandin":[84],"E(2)":[85],"(PGE(2))":[86],"cytokines/chemokines)":[88],"determined":[90],"by":[91,104,177,193,244,338],"Griess":[93],"reaction,":[94],"EIA":[95],"multiplex":[97,178],"ELISA,":[98],"respectively.":[99],"Gene":[100],"expression":[101,182,237,307],"was":[102],"quantified":[103],"RT-PCR.":[105],"its":[108,312],"constituent":[109,313],"galactolipid,":[110],"GLGPG":[111,204,233,270,288,314],"(galactolipid":[112],"(2S)-1,":[113],"2-di-O-[(9Z,":[114],"12Z,":[115],"15Z)-octadeca-9,":[116],"12,":[117],"15-trienoyl]-3-O-\u03b2-D-galactopyranosyl":[118],"glycerol),":[119],"added":[121],"at":[122],"various":[123],"concentrations":[124],"on":[128,302],"biochemical":[129,332],"molecular":[131,330],"parameters":[132],"evaluated.":[134],"(2)":[135],"SW1353":[136,226],"chondrosarcoma":[137],"primary":[140,229],"knee":[142],"articular":[143],"chondrocytes":[144],"(NHAC-kn)":[145],"treated":[147],"interleukin":[149],"(IL)-1\u03b2":[150],"induce":[152],"similar":[156],"those":[158,274],"occurring":[159],"during":[160],"vivo":[162],"degradation":[163],"cartilage.":[165],"Biomarkers":[166],"related":[167],"OA":[169],"(NO,":[170],"PGE(2),":[171],"cytokines,":[172],"chemokines,":[173],"metalloproteinases)":[174],"measured":[176],"ELISA":[179],"gene":[181,236],"analysis":[183],"chondrocytes.":[185],"We":[186],"investigated":[187],"modulation":[189],"these":[191],"events":[192],"GLGPG.":[196,284],"RESULTS:":[197],"In":[198,225],"macrophages":[199],"PBL,":[201],"inhibited":[205],"NO":[206],"PGE(2)":[208],"production":[209,304],"reduced":[211],"secretion":[213,241],"cytokines":[215],"(TNF-\u03b1,":[216],"IFN-\u03b3,":[217],"IL-1\u03b2,":[218],"IL-6,":[219],"IL-12)":[220],"chemokines":[222],"(CCL5/RANTES,":[223],"CXCL10/IP-10).":[224],"chondrocytes,":[230],"diminished":[234],"catabolic":[235,316],"protein":[240,258],"lower":[245],"mRNA":[246],"levels":[247],"matrix":[249],"metalloproteinases":[250],"(MMP-1,":[251],"MMP-3,":[252],"MMP-13),":[253],"aggrecanase":[254],"(ADAMTS-4),":[255],"macrophage":[256],"(MIP-2,":[259],"MIP-3\u03b1),":[260],"CCL5/RANTES,":[261],"CXCL10/IP-10,":[262],"IL-8,":[263],"IL-1\u03b1":[264],"IL-6.":[266],"The":[267,300],"weaker":[272],"than":[273],"RHP,":[276],"presumably":[278],"contains":[279],"other":[280],"chondro-protective":[281],"substances":[282],"besides":[283],"CONCLUSIONS:":[285],"attenuate":[289],"responses":[291],"different":[293],"cellular":[294],"PBLs":[297],"chondrocytes).":[299],"cytokine":[303],"MMP":[306],"indicate":[308],"down-regulate":[315],"associated":[318],"(OA)":[321],"rheumatoid":[323],"arthritis":[324],"(RA).":[325],"These":[326],"data":[327],"provide":[328],"a":[329],"basis":[333],"for":[334],"cartilage":[335],"protection":[336],"provided":[337]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}