{"id":"https://openalex.org/W2048425686","doi":"https://doi.org/10.1074/jbc.m112.381046","title":"Wingless-type Mammary Tumor Virus Integration Site Family, Member 5A (Wnt5a) Regulates Human Immunodeficiency Virus Type 1 (HIV-1) Envelope Glycoprotein 120 (gp120)-induced Expression of Pro-Inflammatory Cytokines via the Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and c-Jun N-terminal Kinase (JNK) Signaling Pathways","display_name":"Wingless-type Mammary Tumor Virus Integration Site Family, Member 5A (Wnt5a) Regulates Human Immunodeficiency Virus Type 1 (HIV-1) Envelope Glycoprotein 120 (gp120)-induced Expression of Pro-Inflammatory Cytokines via the Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and c-Jun N-terminal Kinase (JNK) Signaling Pathways","publication_year":2013,"publication_date":"2013-03-29","ids":{"openalex":"https://openalex.org/W2048425686","doi":"https://doi.org/10.1074/jbc.m112.381046","mag":"2048425686","pmid":"https://pubmed.ncbi.nlm.nih.gov/23539626","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3650396"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112.381046","doi":"https://doi.org/10.1074/jbc.m112.381046","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.381046","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m112.381046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100356443","display_name":"Bei Li","orcid":"https://orcid.org/0000-0001-6901-6420","observed_orcids":["https://orcid.org/0000-0001-6901-6420"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bei Li","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA","Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555","Hainan Provincial Institute for Drug Control, Haikou, Hainan 570216, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Hainan Provincial Institute for Drug Control, Haikou, Hainan 570216, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009838803","display_name":"Yuqiang Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuqiang Shi","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032958129","display_name":"Jianhong Shu","orcid":"https://orcid.org/0000-0002-1080-9108","observed_orcids":["https://orcid.org/0000-0002-1080-9108"]},"institutions":[{"id":"https://openalex.org/I1328775524","display_name":"Zhejiang Sci-Tech University","ror":"https://ror.org/03893we55","country_code":"CN","type":"education","lineage":["https://openalex.org/I1328775524"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jianhong Shu","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555","Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China","institution_ids":["https://openalex.org/I1328775524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101674157","display_name":"Junling Gao","orcid":"https://orcid.org/0000-0002-9727-1338","observed_orcids":["https://orcid.org/0000-0002-9727-1338"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junling Gao","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473021","display_name":"Ping Wu","orcid":"https://orcid.org/0000-0002-7020-6237","observed_orcids":["https://orcid.org/0000-0002-7020-6237"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Wu","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038577267","display_name":"Shao\u2010Jun Tang","orcid":"https://orcid.org/0000-0002-6076-5481","observed_orcids":["https://orcid.org/0000-0002-6076-5481"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shao-Jun Tang","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038577267"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.0696,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.87918552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"288","issue":"19","first_page":"13610","last_page":"13619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt5a","display_name":"Wnt5a","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hiv-1-gp120","display_name":"HIV-1 gp120","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7839999794960022},{"id":"https://openalex.org/keywords/camkii-signaling","display_name":"CaMKII signaling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.9869999885559082},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.8050000071525574},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.875},{"id":"https://openalex.org/keywords/hiv-associated-neurological-disorders","display_name":"HIV-associated neurological disease","score":0.8519999980926514},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.7049999833106995},{"id":"https://openalex.org/keywords/chronic-hiv-infection","display_name":"chronic HIV infection","score":0.46299999952316284},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2780176071","wikidata":"https://www.wikidata.org/wiki/Q18032361","display_name":"WNT5A","level":4,"score":0.6907119154930115},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6685158014297485},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6246300935745239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6172240376472473},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5878204107284546},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5832715034484863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5552006959915161},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.541423499584198},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4552016854286194},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.33534467220306396},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.2449052631855011}],"mesh":[{"descriptor_ui":"D000071818","descriptor_name":"Wnt-5a Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m112.381046","doi":"https://doi.org/10.1074/jbc.m112.381046","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.381046","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2992214","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3650396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3650396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3650396","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:23539626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23539626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112.381046","doi":"https://doi.org/10.1074/jbc.m112.381046","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.381046","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6532358745","display_name":"Pathogenic Mechanisms of HIV-Associated Pain","funder_award_id":"R01NS079166","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7793970971","display_name":"Interplay of HIV-1 gp120 and opioids in astrocyte activation","funder_award_id":"R01DA036165","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W565127267","https://openalex.org/W1511350327","https://openalex.org/W1602964111","https://openalex.org/W1817103017","https://openalex.org/W1973526162","https://openalex.org/W1978047924","https://openalex.org/W1981484636","https://openalex.org/W1994829994","https://openalex.org/W1998225973","https://openalex.org/W2004998891","https://openalex.org/W2006595571","https://openalex.org/W2007076203","https://openalex.org/W2010040953","https://openalex.org/W2015974087","https://openalex.org/W2016448869","https://openalex.org/W2016836786","https://openalex.org/W2018204780","https://openalex.org/W2019108043","https://openalex.org/W2020586880","https://openalex.org/W2021235911","https://openalex.org/W2022634850","https://openalex.org/W2023186669","https://openalex.org/W2030685002","https://openalex.org/W2031036912","https://openalex.org/W2033971249","https://openalex.org/W2034021063","https://openalex.org/W2034102455","https://openalex.org/W2038968007","https://openalex.org/W2050488012","https://openalex.org/W2055557491","https://openalex.org/W2059979104","https://openalex.org/W2061791832","https://openalex.org/W2062113336","https://openalex.org/W2064153835","https://openalex.org/W2067056588","https://openalex.org/W2068784545","https://openalex.org/W2072846008","https://openalex.org/W2074455521","https://openalex.org/W2081476431","https://openalex.org/W2082574041","https://openalex.org/W2085011864","https://openalex.org/W2087959682","https://openalex.org/W2089074317","https://openalex.org/W2089171992","https://openalex.org/W2091323534","https://openalex.org/W2096931514","https://openalex.org/W2097221719","https://openalex.org/W2097527975","https://openalex.org/W2099011309","https://openalex.org/W2104813699","https://openalex.org/W2113246377","https://openalex.org/W2119048927","https://openalex.org/W2120453416","https://openalex.org/W2124701846","https://openalex.org/W2126709873","https://openalex.org/W2127459075","https://openalex.org/W2128027922","https://openalex.org/W2141140780","https://openalex.org/W2142618969","https://openalex.org/W2142884277","https://openalex.org/W2146455000","https://openalex.org/W2156364336","https://openalex.org/W2157374802","https://openalex.org/W2164012871","https://openalex.org/W2164964874","https://openalex.org/W2169745984","https://openalex.org/W2171986099","https://openalex.org/W3085062646"],"related_works":["https://openalex.org/W2037211461","https://openalex.org/W2032812716","https://openalex.org/W2113246377","https://openalex.org/W2722121236","https://openalex.org/W1994829994","https://openalex.org/W1032381249","https://openalex.org/W273961921","https://openalex.org/W2132817620","https://openalex.org/W1996446259","https://openalex.org/W2901824260"],"abstract_inverted_index":{"BACKGROUND:":[0],"HIV-1":[1,19,53],"infection":[2],"causes":[3],"chronic":[4],"neuroinflammation":[5],"in":[6,33,82,98,104,119,148,174,252,261],"the":[7,34,65,73,78,83,99,105,149,160,167,170,185,211,217,223,231,253,262],"central":[8],"nervous":[9],"system":[10],"(CNS).":[11],"RESULTS:":[12],"The":[13,44],"spinal":[14,35,106,120,150],"cytokine":[15,31,80,176],"up-regulation":[16,142],"induced":[17,108],"by":[18,39,51,109,125,137,237],"gp120":[20,29,200],"protein":[21],"depends":[22],"on":[23,181],"Wnt5a/CaMKII":[24,212],"and/or":[25],"Wnt5a/JNK":[26,224],"pathways.":[27,239],"CONCLUSION:":[28],"stimulates":[30,159],"expression":[32,58,81,100,161,219,232,257],"cord":[36,107],"dorsal":[37],"horn":[38],"activating":[40],"Wnt5a":[41,96,115,136,158,191,196,245],"signaling.":[42,192,206],"SIGNIFICANCE:":[43],"finding":[45],"reveals":[46],"Wnt":[47],"signaling-mediated":[48],"novel":[49],"mechanisms":[50],"which":[52],"may":[54],"cause":[55],"neuroinflammation.":[56],"Chronic":[57],"of":[59,67,95,101,129,135,143,155,162,169,190,220,233,255,258],"pro-inflammatory":[60,102,259],"cytokines":[61,103,260],"critically":[62],"contributes":[63],"to":[64,201],"pathogenesis":[66],"HIV-associated":[68],"neurological":[69],"disorders":[70],"(HANDs),":[71],"but":[72],"host":[74],"mechanism":[75],"that":[76,133,195,210,244],"regulates":[77],"HIV-induced":[79],"CNS":[84],"remains":[85],"elusive.":[86],"Here,":[87],"we":[88,178,208],"present":[89],"evidence":[90],"for":[91,199,216,227],"a":[92,110,249],"crucial":[93,250],"role":[94,168,251],"signaling":[97,172,246],"major":[111],"HIV-envelope":[112],"protein,":[113],"gp120.":[114,130],"is":[116,197,214,226,235],"mainly":[117],"expressed":[118],"neurons,":[121],"and":[122,146,183,204],"rapidly":[123],"up-regulated":[124],"intrathecal":[126],"injection":[127,153],"(i.t.)":[128,154],"We":[131,193],"show":[132],"inhibition":[134],"specific":[138],"antagonists":[139],"blocks":[140],"gp120-induced":[141,175,218,256],"IL-1\u03b2,":[144,221],"IL-6,":[145],"TNF-\u03b1":[147,228],"cord.":[151],"Conversely,":[152],"purified":[156],"recombinant":[157],"these":[163],"cytokines.":[164],"To":[165],"elucidate":[166],"Wnt5a-regulated":[171],"pathways":[173],"expression,":[177],"have":[179],"focused":[180],"CaMKII":[182,203],"JNKs,":[184],"well":[186],"characterized":[187],"down-stream":[188],"targets":[189],"find":[194],"required":[198],"activate":[202],"JNK":[205],"Furthermore,":[207],"demonstrate":[209],"pathway":[213,225],"critical":[215],"whereas":[222],"expression.":[229],"Meanwhile,":[230],"IL-6":[234],"co-regulated":[236],"both":[238],"These":[240],"results":[241],"collectively":[242],"suggest":[243],"cascades":[247],"play":[248],"regulation":[254],"CNS.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}