{"id":"https://openalex.org/W2048394134","doi":"https://doi.org/10.1182/blood-2006-04-017392","title":"Involvement of various hematopoietic-cell lineages by the JAK2V617F mutation in polycythemia vera","display_name":"Involvement of various hematopoietic-cell lineages by the JAK2V617F mutation in polycythemia vera","publication_year":2006,"publication_date":"2006-06-07","ids":{"openalex":"https://openalex.org/W2048394134","doi":"https://doi.org/10.1182/blood-2006-04-017392","mag":"2048394134","pmid":"https://pubmed.ncbi.nlm.nih.gov/16757685"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2006-04-017392","doi":"https://doi.org/10.1182/blood-2006-04-017392","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2006-04-017392","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108907871","display_name":"Takefumi Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takefumi Ishii","raw_affiliation_strings":["From the Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL","Section of Hematology/Oncology, University of Illinois College of Medicine, 909 S Wolcott Ave, COMRB, Rm 5035 (M/C 704), Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Section of Hematology/Oncology, University of Illinois College of Medicine, 909 S Wolcott Ave, COMRB, Rm 5035 (M/C 704), Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058425712","display_name":"Edward Bruno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Bruno","raw_affiliation_strings":["From the Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006372952","display_name":"Ronald Hoffman","orcid":"https://orcid.org/0000-0001-6564-6732","observed_orcids":["https://orcid.org/0000-0001-6564-6732"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Hoffman","raw_affiliation_strings":["From the Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033704013","display_name":"Mingjiang Xu","orcid":"https://orcid.org/0000-0002-7063-6253","observed_orcids":["https://orcid.org/0000-0002-7063-6253"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingjiang Xu","raw_affiliation_strings":["From the Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":12.6065,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.9896789,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"108","issue":"9","first_page":"3128","last_page":"3134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":1.0},{"id":"https://openalex.org/keywords/hematopoietic-lineage","display_name":"hematopoietic lineage","score":0.9369999766349792},{"id":"https://openalex.org/keywords/myeloid-lineage","display_name":"myeloid lineage","score":0.6620000004768372},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":1.0},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/clonal-hematopoiesis","display_name":"clonal hematopoiesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.6539999842643738},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.5899999737739563},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.8709999918937683},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mutant-allele-frequency","display_name":"mutant allele frequency","score":0.421999990940094},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.7300707697868347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6847971677780151},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6619952321052551},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5603983402252197},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5533561110496521},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5493060946464539},{"id":"https://openalex.org/C67982717","wikidata":"https://www.wikidata.org/wiki/Q24724397","display_name":"Glycophorin","level":3,"score":0.5397762656211853},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.539092481136322},{"id":"https://openalex.org/C176290653","wikidata":"https://www.wikidata.org/wiki/Q21114013","display_name":"CD33","level":4,"score":0.49002277851104736},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46797966957092285},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42720675468444824},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35074537992477417},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.29093679785728455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2776150703430176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1329268515110016},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1038055419921875}],"mesh":[{"descriptor_ui":"D006021","descriptor_name":"Glycophorins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011087","descriptor_name":"Polycythemia Vera","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2006-04-017392","doi":"https://doi.org/10.1182/blood-2006-04-017392","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2006-04-017392","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:16757685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16757685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328638","display_name":"China International Medical Foundation","ror":"https://ror.org/03hy6ga56"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W2185173","https://openalex.org/W126539919","https://openalex.org/W344393255","https://openalex.org/W1487246151","https://openalex.org/W1571376117","https://openalex.org/W1965116574","https://openalex.org/W1978892900","https://openalex.org/W1980568348","https://openalex.org/W1985187261","https://openalex.org/W1987925274","https://openalex.org/W1996502308","https://openalex.org/W2000991239","https://openalex.org/W2002302430","https://openalex.org/W2005925345","https://openalex.org/W2016692566","https://openalex.org/W2022930434","https://openalex.org/W2029613730","https://openalex.org/W2029818817","https://openalex.org/W2032973700","https://openalex.org/W2038611905","https://openalex.org/W2039285688","https://openalex.org/W2049145190","https://openalex.org/W2057360098","https://openalex.org/W2061370440","https://openalex.org/W2074700940","https://openalex.org/W2079486309","https://openalex.org/W2080755822","https://openalex.org/W2093216476","https://openalex.org/W2095750011","https://openalex.org/W2099762777","https://openalex.org/W2105949419","https://openalex.org/W2117234999","https://openalex.org/W2134699909","https://openalex.org/W2144664431","https://openalex.org/W2152414109","https://openalex.org/W2156318711","https://openalex.org/W2158427750","https://openalex.org/W2161735519","https://openalex.org/W2162258100","https://openalex.org/W2170963974","https://openalex.org/W2327579133","https://openalex.org/W2404783736","https://openalex.org/W2426926330","https://openalex.org/W2460472526","https://openalex.org/W2555811471","https://openalex.org/W4241965933"],"related_works":["https://openalex.org/W2029818817","https://openalex.org/W2051330828","https://openalex.org/W4310126632","https://openalex.org/W2162013503","https://openalex.org/W2905730148","https://openalex.org/W2093290834","https://openalex.org/W2573171762","https://openalex.org/W2993681477","https://openalex.org/W2099194970","https://openalex.org/W2017957175"],"abstract_inverted_index":{"The":[0,80,110],"JAK2(V617F)":[1,68,81,117,144,161],"mutation":[2,24,82,118,145,162],"has":[3],"been":[4],"shown":[5],"to":[6,88,181],"occur":[7],"in":[8,25,33,85,98,103,125,127,167],"the":[9,20,23,26,48,65,91,116,128,143,155,160,168,177],"overwhelming":[10],"majority":[11],"of":[12,22,29,52,67,90,106,112,122,130,133,171],"patients":[13,54,107],"with":[14,55,62,108],"polycythemia":[15],"vera":[16],"(PV).":[17],"To":[18],"study":[19],"role":[21,166],"excessive":[27],"production":[28],"differentiated":[30],"hematopoietic":[31,113],"cells":[32,42,86,114,124],"PV,":[34,172],"CD19+,":[35],"CD3+,":[36],"CD34+,":[37],"CD33+,":[38],"and":[39,43,57,64,94,100,137],"glycophorin":[40],"A+":[41],"granulocytes":[44],"were":[45],"isolated":[46],"from":[47],"peripheral":[49],"blood":[50],"(PB)":[51],"8":[53],"PV":[56,157],"3":[58],"healthy":[59],"donors":[60],"mobilized":[61],"G-CSF,":[63],"percentage":[66],"mutant":[69],"allele":[70],"was":[71,83,95],"determined":[72],"by":[73],"quantitative":[74],"real-time":[75],"polymerase":[76],"chain":[77],"reaction":[78],"(PCR).":[79],"present":[84,97],"belonging":[87],"each":[89],"myeloid":[92],"lineages":[93],"also":[96],"B":[99],"T":[101],"lymphocytes":[102],"a":[104,149],"subpopulation":[105],"PV.":[109,182],"proportion":[111],"expressing":[115],"decreased":[119],"after":[120],"differentiation":[121],"CD34+":[123],"vitro":[126],"presence":[129],"optimal":[131],"concentrations":[132],"SCF,":[134],"IL-3,":[135],"IL-6,":[136],"Epo.":[138],"These":[139],"data":[140],"suggest":[141],"that":[142],"may":[146],"not":[147,176],"provide":[148],"proliferative":[150],"and/or":[151],"survival":[152],"advantage":[153],"for":[154],"abnormal":[156],"clone.":[158],"Although":[159],"plays":[163],"an":[164],"important":[165],"biologic":[169],"origins":[170],"it":[173],"is":[174],"likely":[175],"sole":[178],"event":[179],"leading":[180]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
