{"id":"https://openalex.org/W2048294889","doi":"https://doi.org/10.1242/dev.065508","title":"Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary","display_name":"Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary","publication_year":2011,"publication_date":"2011-05-10","ids":{"openalex":"https://openalex.org/W2048294889","doi":"https://doi.org/10.1242/dev.065508","mag":"2048294889","pmid":"https://pubmed.ncbi.nlm.nih.gov/21558370","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3091492"},"language":"en","primary_location":{"id":"doi:10.1242/dev.065508","doi":"https://doi.org/10.1242/dev.065508","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.065508","pdf_url":"https://journals.biologists.com/dev/article-pdf/138/11/2207/1196396/2207.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.biologists.com/dev/article-pdf/138/11/2207/1196396/2207.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080215650","display_name":"Lucy X. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy X. Morris","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210117844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016264819","display_name":"Allan C. Spradling","orcid":"https://orcid.org/0000-0002-5251-1801","observed_orcids":["https://orcid.org/0000-0002-5251-1801"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan C. Spradling","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210117844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016264819"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210117844"],"apc_list":null,"apc_paid":null,"fwci":5.4395,"has_fulltext":true,"cited_by_count":168,"citation_normalized_percentile":{"value":0.97354425,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"138","issue":"11","first_page":"2207","last_page":"2215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drosophila-ovary","display_name":"Drosophila ovary","score":0.9589999914169312},{"id":"https://openalex.org/keywords/follicle-stem-cells","display_name":"follicle stem cells","score":0.7229999899864197},{"id":"https://openalex.org/keywords/germline-stem-cells","display_name":"germline stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/follicular-development","display_name":"folliculogenesis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/escort-cells","display_name":"escort cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/glial-like-cells","display_name":"glial-like cells","score":0.5809999704360962},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.621999979019165},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mitotic-spindle-orientation","display_name":"mitotic spindle orientation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/stem-cell-quiescence","display_name":"stem cell quiescence","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gametogenesis","display_name":"gametogenesis","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9157947301864624},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8004454970359802},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.756849467754364},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.7510252594947815},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.5905223488807678},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5866875052452087},{"id":"https://openalex.org/C39297687","wikidata":"https://www.wikidata.org/wiki/Q1410510","display_name":"Gametogenesis","level":4,"score":0.5159205198287964},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.47866472601890564},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.4781542718410492},{"id":"https://openalex.org/C5512455","wikidata":"https://www.wikidata.org/wiki/Q2142940","display_name":"Folliculogenesis","level":4,"score":0.4424847364425659},{"id":"https://openalex.org/C163949779","wikidata":"https://www.wikidata.org/wiki/Q507032","display_name":"Oogenesis","level":4,"score":0.4240190088748932},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.37883448600769043},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.37372851371765137},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29990193247795105},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2661607265472412},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.09134021401405334},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.07447963953018188},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.065508","doi":"https://doi.org/10.1242/dev.065508","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.065508","pdf_url":"https://journals.biologists.com/dev/article-pdf/138/11/2207/1196396/2207.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3091492","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3091492","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:21558370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21558370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1242/dev.065508","doi":"https://doi.org/10.1242/dev.065508","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.065508","pdf_url":"https://journals.biologists.com/dev/article-pdf/138/11/2207/1196396/2207.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2048294889.pdf","grobid_xml":"https://content.openalex.org/works/W2048294889.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1545962441","https://openalex.org/W1600103888","https://openalex.org/W1910221226","https://openalex.org/W1968650783","https://openalex.org/W1971913477","https://openalex.org/W1979450683","https://openalex.org/W1983880033","https://openalex.org/W1986814731","https://openalex.org/W1991615598","https://openalex.org/W1999751317","https://openalex.org/W2012668509","https://openalex.org/W2021892293","https://openalex.org/W2031353653","https://openalex.org/W2038211069","https://openalex.org/W2044854823","https://openalex.org/W2045349952","https://openalex.org/W2057697250","https://openalex.org/W2060685261","https://openalex.org/W2062767343","https://openalex.org/W2064236697","https://openalex.org/W2065258374","https://openalex.org/W2066768498","https://openalex.org/W2066818389","https://openalex.org/W2070132269","https://openalex.org/W2076783881","https://openalex.org/W2086265207","https://openalex.org/W2091884095","https://openalex.org/W2094524167","https://openalex.org/W2103046819","https://openalex.org/W2105241495","https://openalex.org/W2106313405","https://openalex.org/W2109472768","https://openalex.org/W2114692975","https://openalex.org/W2115363971","https://openalex.org/W2118806304","https://openalex.org/W2135541869","https://openalex.org/W2144495019","https://openalex.org/W2147026515","https://openalex.org/W2154996517","https://openalex.org/W2164991328","https://openalex.org/W2169337437","https://openalex.org/W2170983659","https://openalex.org/W2182689882","https://openalex.org/W2295049624","https://openalex.org/W7073944887"],"related_works":["https://openalex.org/W2897379042","https://openalex.org/W3135522057","https://openalex.org/W2529985135","https://openalex.org/W4405625380","https://openalex.org/W2053378168","https://openalex.org/W2114692975","https://openalex.org/W2031353653","https://openalex.org/W1600103888","https://openalex.org/W2066818389","https://openalex.org/W2135541869"],"abstract_inverted_index":{"The":[0],"Drosophila":[1],"ovariole":[2],"tip":[3],"produces":[4],"new":[5],"ovarian":[6,54],"follicles":[7],"on":[8],"a":[9,29,47,176],"12-hour":[10],"cycle":[11],"by":[12,155],"controlling":[13],"niche-based":[14],"germline":[15,128],"and":[16,21,60,95,105,124,171],"follicle":[17,43,76],"stem":[18,55,92,129,161],"cell":[19,56,93,130,138,145,180],"divisions":[20],"nurturing":[22],"their":[23,107],"developing":[24],"daughters.":[25],"Static":[26],"images":[27],"provide":[28],"thumbnail":[30],"view":[31],"of":[32,75,91,116,159],"folliculogenesis":[33],"but":[34],"imperfectly":[35],"capture":[36],"the":[37,73,113,147,156],"dynamic":[38],"cellular":[39],"interactions":[40],"that":[41,51,81],"underlie":[42],"production.":[44],"We":[45],"describe":[46],"live-imaging":[48],"culture":[49],"system":[50],"supports":[52],"normal":[53],"activity,":[57],"cyst":[58],"movement":[59],"intercellular":[61],"interaction":[62],"over":[63],"14":[64],"hours,":[65],"which":[66],"is":[67],"long":[68],"enough":[69],"to":[70,87,103,123,146,174],"visualize":[71],"all":[72],"steps":[74],"generation.":[77],"Our":[78],"results":[79],"show":[80],"live":[82],"imaging":[83],"has":[84],"unique":[85],"potential":[86],"address":[88],"diverse":[89],"aspects":[90],"biology":[94],"gametogenesis.":[96],"Stem":[97],"cells":[98,151,162,168],"in":[99],"cultured":[100],"tissue":[101],"respond":[102],"insulin":[104],"orient":[106],"mitotic":[108],"spindles.":[109],"Somatic":[110],"escort":[111,144,150,160,167],"cells,":[112,119],"glial-like":[114],"partners":[115],"early":[117],"germ":[118,178],"do":[120],"not":[121,153],"adhere":[122],"migrate":[125],"along":[126],"with":[127],"daughters":[131],"as":[132,163],"previously":[133,164],"proposed.":[134],"Instead,":[135],"dynamic,":[136],"microtubule-rich":[137],"membranes":[139],"pass":[140],"cysts":[141],"from":[142],"one":[143],"next.":[148],"Additionally,":[149],"are":[152],"replenished":[154],"regular":[157],"division":[158],"suggested.":[165],"Rather,":[166],"remain":[169],"quiescent":[170],"divide":[172],"only":[173],"maintain":[175],"constant":[177],"cell:escort":[179],"ratio.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
