{"id":"https://openalex.org/W2048047330","doi":"https://doi.org/10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.0.co;2-f","title":"Involvement of the low-affinity neurotrophin receptor (p75NTR) in apoptosis of differentiated PC12 cells","display_name":"Involvement of the low-affinity neurotrophin receptor (p75NTR) in apoptosis of differentiated PC12 cells","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W2048047330","doi":"https://doi.org/10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.0.co;2-f","mag":"2048047330"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S196311374","display_name":"Neuroscience Research Communications","issn_l":"0893-6609","issn":["0893-6609","1520-6769"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041979394","display_name":"Scott M. Jenkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott M. Jenkins","raw_affiliation_strings":["Departments of Psychiatry and Psychology, University of Alabama at Birmingham, Birmingham, AL 35294-0017"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Psychology, University of Alabama at Birmingham, Birmingham, AL 35294-0017","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025207687","display_name":"Gail V.W. Johnson","orcid":"https://orcid.org/0000-0003-3464-0404","observed_orcids":["https://orcid.org/0000-0003-3464-0404"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gail V. W. Johnson","raw_affiliation_strings":["Departments of Psychiatry and Psychology, University of Alabama at Birmingham, Birmingham, AL 35294-0017"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Psychology, University of Alabama at Birmingham, Birmingham, AL 35294-0017","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041979394"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":0.1165,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.36773968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"3","first_page":"137","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6420000195503235},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.781000018119812},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9729999899864197},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.984000027179718},{"id":"https://openalex.org/keywords/trk-receptors","display_name":"Trk receptors","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.6710000038146973},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/trophic-support","display_name":"trophic support","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ligand-specificity","display_name":"ligand specificity","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C134139212","wikidata":"https://www.wikidata.org/wiki/Q24719927","display_name":"Trk receptor","level":4,"score":0.7567077875137329},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.7555869817733765},{"id":"https://openalex.org/C56703729","wikidata":"https://www.wikidata.org/wiki/Q14897872","display_name":"Low-affinity nerve growth factor receptor","level":4,"score":0.7080057859420776},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6175864934921265},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6097334027290344},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.5958935618400574},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5272670984268188},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5072112083435059},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4821597933769226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4718572795391083},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4317556917667389},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42662927508354187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35430389642715454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27560967206954956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14659476280212402}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S196311374","display_name":"Neuroscience Research Communications","issn_l":"0893-6609","issn":["0893-6609","1520-6769"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Research Communications","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.3.co;2-6","doi":"https://doi.org/10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.3.co;2-6","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6769(199705)20:3<137::aid-nrc195>3.3.co;2-6","pdf_url":null,"source":{"id":"https://openalex.org/S196311374","display_name":"Neuroscience Research Communications","issn_l":"0893-6609","issn":["0893-6609","1520-6769"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Research Communications","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090193932","https://openalex.org/W2063639508","https://openalex.org/W2131870085","https://openalex.org/W2163706911","https://openalex.org/W2411593190","https://openalex.org/W2385433995","https://openalex.org/W2332793877","https://openalex.org/W4245275885","https://openalex.org/W2093983913","https://openalex.org/W1996019192"],"abstract_inverted_index":{"Although":[0],"the":[1,4,39,42,50,79,102,109,112],"function":[2],"of":[3,32,44,117,123,127,137,152,162],"low-affinity":[5],"neurotrophin":[6],"receptor":[7,129],"(p75NTR)":[8],"has":[9],"not":[10],"yet":[11],"been":[12],"clearly":[13],"established,":[14],"there":[15],"is":[16],"increasing":[17],"evidence":[18],"to":[19,52,78,100,159],"suggest":[20],"that":[21,69,111,135],"it":[22],"may":[23,156],"play":[24],"a":[25,75,91,172],"role":[26],"in":[27,144,171],"determining":[28],"cell":[29,147],"viability":[30],"independent":[31,126],"an":[33],"interaction":[34],"with":[35],"Trk":[36,128],"receptors.":[37],"In":[38,86],"present":[40],"study,":[41],"ability":[43],"both":[45,70],"neurotrophins":[46],"and":[47,74,96],"antibodies":[48],"against":[49,146],"p75NTR":[51,80,93,113,138,170],"rescue":[53,101],"differentiated":[54,103,118],"PC12":[55,104,119],"cells":[56,83,120],"from":[57,84],"apoptotic":[58],"death":[59,148],"induced":[60],"by":[61,140,150,169],"serum":[62],"withdrawal":[63],"was":[64],"examined.":[65],"The":[66],"results":[67,107,143],"demonstrate":[68,134],"nerve":[71],"growth":[72],"factor":[73],"polyclonal":[76],"antibody":[77,94],"effectively":[81],"rescued":[82],"apoptosis.":[85],"contrast,":[87],"brain-derived":[88],"neurotrophic":[89],"factor,":[90],"monoclonal":[92],"(192-IgG),":[95],"non-immune":[97],"IgG":[98],"failed":[99],"cells.":[105],"These":[106,131],"support":[108,125],"hypothesis":[110],"can":[114],"mediate":[115],"survival":[116],"after":[121],"removal":[122,151],"trophic":[124,153],"activity.":[130],"data":[132],"also":[133],"occupancy":[136],"only":[139],"specific":[141,163],"ligands":[142],"protection":[145],"invoked":[149],"support.":[154],"This":[155],"be":[157],"due":[158],"select":[160],"activation":[161],"intracellular":[164],"cascades":[165],"which":[166],"are":[167],"modulated":[168],"ligand-specific":[173],"manner.":[174],"\u00a9":[175],"1997":[176],"John":[177],"Wiley":[178],"&":[179],"Sons,":[180],"Ltd.":[181]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}