{"id":"https://openalex.org/W2048032392","doi":"https://doi.org/10.1615/critrevtherdrugcarriersyst.v14.i2.10","title":"The Role of Immunoproteins in the Survival","display_name":"The Role of Immunoproteins in the Survival","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2048032392","doi":"https://doi.org/10.1615/critrevtherdrugcarriersyst.v14.i2.10","mag":"2048032392","pmid":"https://pubmed.ncbi.nlm.nih.gov/9107519"},"language":"en","primary_location":{"id":"doi:10.1615/critrevtherdrugcarriersyst.v14.i2.10","doi":"https://doi.org/10.1615/critrevtherdrugcarriersyst.v14.i2.10","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevtherdrugcarriersyst.v14.i2.10","pdf_url":null,"source":{"id":"https://openalex.org/S22829174","display_name":"Critical Reviews in Therapeutic Drug Carrier Systems","issn_l":"0743-4863","issn":["0743-4863","2162-660X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u0099 in Therapeutic Drug Carrier Systems","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006207744","display_name":"Dana V. Devine","orcid":"https://orcid.org/0000-0002-9059-0344","observed_orcids":["https://orcid.org/0000-0002-9059-0344"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I51917231","display_name":"Canadian Red Cross Society","ror":"https://ror.org/01t0p7s78","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I51917231"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dana V. Devine","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook  Mall,Vancouver, B.C. V6T 2B5, Canada; and The Canadian Red Cross Society Blood Services,Vancouver,Canada","Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook  Mall,Vancouver, B.C. V6T 2B5, Canada","The Canadian Red Cross Society Blood Services,Vancouver,Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook  Mall,Vancouver, B.C. V6T 2B5, Canada; and The Canadian Red Cross Society Blood Services,Vancouver,Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I51917231"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook  Mall,Vancouver, B.C. V6T 2B5, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"The Canadian Red Cross Society Blood Services,Vancouver,Canada","institution_ids":["https://openalex.org/I51917231"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026208938","display_name":"Jihan M.J. Marjan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jihan M. J. Marjan","raw_affiliation_strings":["Department of  Pharmacology, University of Alberta, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of  Pharmacology, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9899,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.90275908,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"2","first_page":"27","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposome-clearance","display_name":"liposome clearance","score":0.875},{"id":"https://openalex.org/keywords/reticuloendothelial-system","display_name":"reticuloendothelial system","score":0.9049999713897705},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.777999997138977},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.8970000147819519},{"id":"https://openalex.org/keywords/antibody-binding","display_name":"antibody binding","score":0.8889999985694885},{"id":"https://openalex.org/keywords/plasma-proteins","display_name":"plasma proteins","score":0.8809999823570251},{"id":"https://openalex.org/keywords/liposome-biodistribution","display_name":"liposome biodistribution","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.8220142126083374},{"id":"https://openalex.org/C19702531","wikidata":"https://www.wikidata.org/wiki/Q929966","display_name":"Mononuclear phagocyte system","level":2,"score":0.6771154999732971},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6653332710266113},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6110588312149048},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5589752793312073},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.4833666682243347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43077534437179565},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39379385113716125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37728387117385864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3178291320800781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3054552972316742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22301211953163147},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009895","descriptor_name":"Opsonin Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1615/critrevtherdrugcarriersyst.v14.i2.10","doi":"https://doi.org/10.1615/critrevtherdrugcarriersyst.v14.i2.10","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevtherdrugcarriersyst.v14.i2.10","pdf_url":null,"source":{"id":"https://openalex.org/S22829174","display_name":"Critical Reviews in Therapeutic Drug Carrier Systems","issn_l":"0743-4863","issn":["0743-4863","2162-660X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u0099 in Therapeutic Drug Carrier Systems","raw_type":"journal-article"},{"id":"pmid:9107519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9107519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in therapeutic drug carrier systems","raw_type":"Journal Article"},{"id":"mag:2415782992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9107519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2415782992","https://openalex.org/W2000121492","https://openalex.org/W2256379121","https://openalex.org/W2490781136","https://openalex.org/W2293875620","https://openalex.org/W2157485847","https://openalex.org/W2005367319","https://openalex.org/W1596131832","https://openalex.org/W2345230548","https://openalex.org/W184474482"],"abstract_inverted_index":{"The":[0],"clearance":[1],"of":[2,13,31,33,58,68],"liposomes":[3,69],"from":[4],"the":[5,11,14,29,34,46,56,64],"circulation":[6],"is":[7,70],"mediated":[8],"largely":[9],"by":[10],"cells":[12,18],"reticuloendothelial":[15],"system.":[16],"These":[17],"recognize":[19],"liposome-bound":[20],"immunoproteins,":[21],"particularly":[22],"immunoglobulins":[23],"and":[24,42,45,52,60],"complement.":[25],"This":[26],"review":[27],"addresses":[28],"state":[30],"knowledge":[32],"plasma":[35],"proteins":[36,51],"that":[37],"can":[38],"initiate":[39],"complement":[40],"activation":[41],"antibody":[43],"binding":[44],"known":[47],"interactions":[48],"among":[49],"these":[50],"liposomes.":[53],"Evidence":[54],"for":[55],"involvement":[57],"immunoproteins":[59],"other":[61],"molecules":[62],"in":[63,65],"vivo":[66],"survival":[67],"also":[71],"reviewed.":[72]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}