{"id":"https://openalex.org/W2048024360","doi":"https://doi.org/10.1016/s0168-8278(88)80504-x","title":"Primary culture of cryopreserved adult human hepatocytes on homologous extracellular matrix and the influence of monocytic products on albumin synthesis","display_name":"Primary culture of cryopreserved adult human hepatocytes on homologous extracellular matrix and the influence of monocytic products on albumin synthesis","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2048024360","doi":"https://doi.org/10.1016/s0168-8278(88)80504-x","mag":"2048024360","pmid":"https://pubmed.ncbi.nlm.nih.gov/2460521"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-8278(88)80504-x","doi":"https://doi.org/10.1016/s0168-8278(88)80504-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(88)80504-x","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043968888","display_name":"Han J. Moshage","orcid":"https://orcid.org/0000-0002-4764-0246","observed_orcids":["https://orcid.org/0000-0002-4764-0246"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H.J. Moshage","raw_affiliation_strings":["Department of Medicine, University Hospital of Nijmegen, The Netherlands","Divisions of Gastrointestinal and Liver Diseases, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital of Nijmegen, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Divisions of Gastrointestinal and Liver Diseases, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090583614","display_name":"P. J. M. Rijntjes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P.J.M. Rijntjes","raw_affiliation_strings":["Divisions of Gastrointestinal and Liver Diseases, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Gastrointestinal and Liver Diseases, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111839775","display_name":"Jan C. M. Hafkenscheid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.C.M. Hafkenscheid","raw_affiliation_strings":["Divisions of Clinical Chemistry, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Chemistry, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022207213","display_name":"H.M.J. Roelofs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H.M.J. Roelofs","raw_affiliation_strings":["Divisions of Gastrointestinal and Liver Diseases, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Gastrointestinal and Liver Diseases, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111838651","display_name":"Sing Hiem Yap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"S.H. Yap","raw_affiliation_strings":["Divisions of Gastrointestinal and Liver Diseases, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Gastrointestinal and Liver Diseases, Department of Medicine, University Hospital of Nijmegen, Nijmegen (The Netherlands)","institution_ids":["https://openalex.org/I145872427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111838651"],"corresponding_institution_ids":["https://openalex.org/I145872427"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.7522,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.83830911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"34","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-hepatocytes","display_name":"human hepatocytes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/primary-hepatocyte-culture","display_name":"primary hepatocyte culture","score":0.7950000166893005},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.949999988079071},{"id":"https://openalex.org/keywords/cell-attachment","display_name":"cell attachment","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hepatocyte-viability","display_name":"hepatocyte viability","score":0.9139999747276306},{"id":"https://openalex.org/keywords/albumin-synthesis","display_name":"albumin synthesis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.9700000286102295},{"id":"https://openalex.org/keywords/total-protein-synthesis","display_name":"total protein synthesis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.7722785472869873},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.6909834146499634},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.682391881942749},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6130470037460327},{"id":"https://openalex.org/C2994367422","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Primary culture","level":3,"score":0.5932866930961609},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5066074132919312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4572964608669281},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.44799676537513733},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4328538477420807},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4144169092178345},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33526092767715454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2930491268634796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22007668018341064},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.158330500125885},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.08216765522956848},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.058883458375930786},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.05359053611755371}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0168-8278(88)80504-x","doi":"https://doi.org/10.1016/s0168-8278(88)80504-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(88)80504-x","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},{"id":"pmid:2460521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2460521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1503521828","https://openalex.org/W1941199801","https://openalex.org/W1971161082","https://openalex.org/W1974783983","https://openalex.org/W1979348855","https://openalex.org/W1989431810","https://openalex.org/W1991236676","https://openalex.org/W2000834887","https://openalex.org/W2002983094","https://openalex.org/W2007802831","https://openalex.org/W2013672165","https://openalex.org/W2034013376","https://openalex.org/W2042152404","https://openalex.org/W2058153935","https://openalex.org/W2061092255","https://openalex.org/W2061954876","https://openalex.org/W2071356981","https://openalex.org/W2079669800","https://openalex.org/W2088227793","https://openalex.org/W2109769822","https://openalex.org/W2253986594","https://openalex.org/W2411053432","https://openalex.org/W2466534437","https://openalex.org/W2977569009"],"related_works":["https://openalex.org/W1941199801","https://openalex.org/W175670171","https://openalex.org/W2466858045","https://openalex.org/W2006686106","https://openalex.org/W2071356981","https://openalex.org/W2094082503","https://openalex.org/W2134719977","https://openalex.org/W4233301082","https://openalex.org/W2331222496","https://openalex.org/W2068301983"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}