{"id":"https://openalex.org/W2048008367","doi":"https://doi.org/10.1113/jphysiol.1994.sp020370","title":"Na+ channel mis\u2010expression accelerates K+ channel development in embryonic Xenopus laevis skeletal muscle.","display_name":"Na+ channel mis\u2010expression accelerates K+ channel development in embryonic Xenopus laevis skeletal muscle.","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W2048008367","doi":"https://doi.org/10.1113/jphysiol.1994.sp020370","mag":"2048008367","pmid":"https://pubmed.ncbi.nlm.nih.gov/7869255","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1155815"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1994.sp020370","doi":"https://doi.org/10.1113/jphysiol.1994.sp020370","is_oa":true,"landing_page_url":"https://doi.org/10.1113/jphysiol.1994.sp020370","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/jphysiol.1994.sp020370","source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/jphysiol.1994.sp020370","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033237248","display_name":"Paul Linsdell","orcid":"https://orcid.org/0000-0001-6257-6273","observed_orcids":["https://orcid.org/0000-0001-6257-6273"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Linsdell","raw_affiliation_strings":["Department of Zoology, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090298967","display_name":"William J. Moody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W J Moody","raw_affiliation_strings":["Department of Zoology, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":1.2656,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.79238714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"480","issue":"3","first_page":"405","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.8100000023841858},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.7940000295639038},{"id":"https://openalex.org/keywords/skeletal-muscle-development","display_name":"skeletal muscle development","score":0.7120000123977661},{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.843999981880188},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mrna-injection","display_name":"mRNA injection","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.8938865661621094},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6125127077102661},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6091214418411255},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.5959672927856445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5071189403533936},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4868451952934265},{"id":"https://openalex.org/C153461711","wikidata":"https://www.wikidata.org/wiki/Q5072487","display_name":"Channel blocker","level":3,"score":0.44988352060317993},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.443270206451416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4282941222190857},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4249504804611206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4012010991573334},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1798894703388214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13572365045547485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09462150931358337},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1994.sp020370","doi":"https://doi.org/10.1113/jphysiol.1994.sp020370","is_oa":true,"landing_page_url":"https://doi.org/10.1113/jphysiol.1994.sp020370","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/jphysiol.1994.sp020370","source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1155815","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1155815","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:7869255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7869255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1113/jphysiol.1994.sp020370","doi":"https://doi.org/10.1113/jphysiol.1994.sp020370","is_oa":true,"landing_page_url":"https://doi.org/10.1113/jphysiol.1994.sp020370","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/jphysiol.1994.sp020370","source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4251480945","display_name":null,"funder_award_id":"HD 17486","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G549400383","display_name":"DEVELOPMENTAL MODULATION OF ION CHANNEL PROPERTIES","funder_award_id":"5r01hd017486-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2048008367.pdf"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1608420792","https://openalex.org/W1985146688","https://openalex.org/W1997511216","https://openalex.org/W2004002713","https://openalex.org/W2009667219","https://openalex.org/W2011920501","https://openalex.org/W2015426350","https://openalex.org/W2015648089","https://openalex.org/W2037384321","https://openalex.org/W2051431785","https://openalex.org/W2083516287","https://openalex.org/W2087301046","https://openalex.org/W2112796297"],"related_works":["https://openalex.org/W2344280024","https://openalex.org/W1597565396","https://openalex.org/W1535575187","https://openalex.org/W1605391828","https://openalex.org/W1990054991","https://openalex.org/W2032043530","https://openalex.org/W1966782574","https://openalex.org/W1553690038","https://openalex.org/W2087301046","https://openalex.org/W2023898046"],"abstract_inverted_index":{"1.":[0],"The":[1],"normal":[2,157],"developmental":[3,50],"pattern":[4],"of":[5,15,24,33,79,84,123],"voltage-gated":[6,64],"ion":[7],"channel":[8,34,100,111,119,146],"expression":[9,78,94],"in":[10,44,91,117,127],"embryonic":[11],"skeletal":[12],"muscle":[13,45,158],"cells":[14,46,60,71],"the":[16,48,98],"frog":[17],"Xenopus":[18],"laevis":[19],"was":[20,95],"disrupted":[21],"by":[22,97,109,144],"introduction":[23],"cloned":[25],"rat":[26],"brain":[27],"Na+":[28,40,74,99,110,125,145,151],"channels.":[29],"2.":[30],"Following":[31],"injection":[32],"mRNA":[35],"into":[36],"fertilized":[37],"eggs,":[38],"large":[39],"currents":[41,65],"were":[42],"observed":[43],"at":[47,52,66,80],"earliest":[49],"stage":[51],"which":[53],"they":[54],"could":[55],"be":[56],"uniquely":[57],"identified.":[58],"Muscle":[59,70],"normally":[61],"have":[62],"no":[63],"this":[67],"stage.":[68],"3.":[69],"expressing":[72],"exogenous":[73],"channels":[75,126],"showed":[76],"increased":[77,105],"least":[81],"two":[82],"classes":[83],"endogenous":[85,124],"K+":[86,92,118,132,153],"currents.":[87],"4.":[88],"This":[89],"increase":[90,116],"current":[93,133,154],"inhibited":[96],"blocker":[101],"tetrodotoxin,":[102],"suggesting":[103],"that":[104,136,142],"electrical":[106],"activity":[107],"caused":[108],"mis-expression":[112,147],"triggers":[113],"a":[114,137],"compensatory":[115,139],"expression.":[120],"5.":[121],"Block":[122],"later":[128],"control":[129],"myocytes":[130],"retards":[131],"development,":[134],"indicating":[135],"similar":[138],"mechanism":[140],"to":[141,149],"triggered":[143],"operates":[148],"balance":[150],"and":[152],"densities":[155],"during":[156],"development.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
