{"id":"https://openalex.org/W2047923976","doi":"https://doi.org/10.1158/1538-7445.am10-340","title":"Abstract 340: Kaempferol inhibits angiogenesis and tumorigenesis by regulating Akt-HIF, cMyc-p21, and ERR\u03b1 genes","display_name":"Abstract 340: Kaempferol inhibits angiogenesis and tumorigenesis by regulating Akt-HIF, cMyc-p21, and ERR\u03b1 genes","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2047923976","doi":"https://doi.org/10.1158/1538-7445.am10-340","mag":"2047923976"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-340","doi":"https://doi.org/10.1158/1538-7445.am10-340","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-340","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102210991","display_name":"Haitao Luo","orcid":"https://orcid.org/0009-0009-0844-6406","observed_orcids":["https://orcid.org/0009-0009-0844-6406"]},"institutions":[{"id":"https://openalex.org/I249887453","display_name":"Alderson Broaddus University","ror":"https://ror.org/04wkwbq27","country_code":"US","type":"education","lineage":["https://openalex.org/I249887453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haitao Luo","raw_affiliation_strings":["1Alderson-Broaddus College, Philippi, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Alderson-Broaddus College, Philippi, WV","institution_ids":["https://openalex.org/I249887453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026517567","display_name":"Gary O'Neal Rankin","orcid":"https://orcid.org/0000-0002-5385-3512","observed_orcids":["https://orcid.org/0000-0002-5385-3512"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Rankin","raw_affiliation_strings":["2Marshall University, Huntington, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Marshall University, Huntington, WV","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010837478","display_name":"Ann Federoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I249887453","display_name":"Alderson Broaddus University","ror":"https://ror.org/04wkwbq27","country_code":"US","type":"education","lineage":["https://openalex.org/I249887453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Federoff","raw_affiliation_strings":["1Alderson-Broaddus College, Philippi, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Alderson-Broaddus College, Philippi, WV","institution_ids":["https://openalex.org/I249887453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028548977","display_name":"Noelle Juliano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I249887453","display_name":"Alderson Broaddus University","ror":"https://ror.org/04wkwbq27","country_code":"US","type":"education","lineage":["https://openalex.org/I249887453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noelle Juliano","raw_affiliation_strings":["1Alderson-Broaddus College, Philippi, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Alderson-Broaddus College, Philippi, WV","institution_ids":["https://openalex.org/I249887453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055653838","display_name":"Bing\u2010Hua Jiang","orcid":"https://orcid.org/0000-0003-4526-2031","observed_orcids":["https://orcid.org/0000-0003-4526-2031"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing-Hua Jiang","raw_affiliation_strings":["3West Virginia University, Morgantown, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3West Virginia University, Morgantown, WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100419218","display_name":"Yi Chen","orcid":"https://orcid.org/0000-0001-6865-9512","observed_orcids":["https://orcid.org/0000-0001-6865-9512"]},"institutions":[{"id":"https://openalex.org/I249887453","display_name":"Alderson Broaddus University","ror":"https://ror.org/04wkwbq27","country_code":"US","type":"education","lineage":["https://openalex.org/I249887453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi C. Chen","raw_affiliation_strings":["1Alderson-Broaddus College, Philippi, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Alderson-Broaddus College, Philippi, WV","institution_ids":["https://openalex.org/I249887453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"340","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.2493000030517578,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":1.0},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.9769999980926514},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6079999804496765},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/estrogen-related-receptor-alpha","display_name":"estrogen-related receptor alpha","score":0.7910000085830688},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.875},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dietary-phytochemicals","display_name":"dietary phytochemicals","score":0.6549999713897705},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.796999990940094},{"id":"https://openalex.org/keywords/ovcar-3-cells","display_name":"OVCAR-3 cells","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8244550228118896},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.7284335494041443},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5875484347343445},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.52895188331604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5087819695472717},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5038344264030457},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4989604949951172},{"id":"https://openalex.org/C97230052","wikidata":"https://www.wikidata.org/wiki/Q3854334","display_name":"Chorioallantoic membrane","level":3,"score":0.46310800313949585},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4617958068847656},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4286792278289795},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.42590320110321045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4148680567741394},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4108266830444336},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.336626797914505},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3063772916793823},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.23927295207977295},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23840126395225525},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2089613378047943},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20517024397850037},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.12308245897293091},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10137933492660522},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.09302628040313721},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0786234438419342},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-340","doi":"https://doi.org/10.1158/1538-7445.am10-340","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-340","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011984268","https://openalex.org/W2900971827","https://openalex.org/W2057164395","https://openalex.org/W2791587093","https://openalex.org/W2793450445","https://openalex.org/W2110377062","https://openalex.org/W4410154744","https://openalex.org/W1486891320","https://openalex.org/W2132772974","https://openalex.org/W1946811"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"study":[2,133,234],"was":[3,81,103,249],"designed":[4],"to":[5],"investigate":[6,92],"kaempferol's":[7,93,174,223,255],"effects":[8,27,94,121,199,225],"on":[9,28,95,176,200,226,251],"VEGF":[10,29,44,96,126,141,177,190,201,227],"expression":[11,30,99,202,228],"and":[12,18,36,42,49,60,118,144,147,165,171,211,246,268,274,282],"angiogenesis":[13,51],"in":[14,31,72,139,173,189,209,229,242,279],"ovarian":[15,32,73,230,243,272],"cancer":[16,33,74,231,244],"cells":[17,59,75],"the":[19,98,119,252,294,299],"underlying":[20],"mechanisms/pathways":[21,161,253],"responsible":[22],"for":[23,162,169,222,240,254,266,302],"these":[24,163],"effects.":[25,256],"Kaempferol's":[26],"cells,":[34,245],"OVCAR-3":[35,210],"A2780/CP70,":[37],"were":[38,52],"studied":[39,53],"with":[40,54,77,83],"ELISA":[41,88],"a":[43,125,167,182,219,258,263],"promoter":[45,127],"reporter":[46,128],"assay.":[47],"In-vitro":[48],"in-vivo":[50,145,148],"human":[55,283],"umbilical":[56],"vein":[57],"endothelial":[58],"chicken":[61],"embryo":[62],"chorioallantoic":[63],"membranes,":[64],"respectively.":[65],"Expression":[66],"or":[67,87,111,130],"phosphorylation":[68],"of":[69,100,108,116,271,293,298],"pertinent":[70],"genes":[71,102],"treated":[76],"kaempferol":[78,136,196,237,261],"(0-160":[79],"\u00b5M)":[80],"examined":[82],"RT-qPCR,":[84],"western":[85],"blot,":[86],"as":[89,218],"appropriate.":[90],"To":[91],"expression,":[97,142],"certain":[101],"either":[104],"enhanced":[105],"by":[106,114,123],"transfection":[107,115],"plasmid":[109],"DNA":[110],"knocked":[112],"down":[113],"siRNA,":[117],"resultant":[120],"evaluated":[122],"using":[124],"assay":[129],"RT-qPCR.":[131],"Our":[132,192,233],"found":[134,235],"that":[135,181,195,236],"is":[137,186,238,262],"effective":[138,239],"inhibiting":[140],"in-vitro":[143],"angiogenesis,":[146],"tumorigenesis":[149],"at":[150],"physiologically":[151],"relevant":[152],"concentrations":[153],"(e.g.":[154],"40":[155],"\u00b5M).":[156],"We":[157,179,214],"further":[158,277],"looked":[159],"into":[160],"effects,":[164],"confirmed":[166],"role":[168],"Akt":[170],"HIF-1\u03b1":[172],"inhibition":[175],"expression.":[178],"discovered":[180],"new":[183,247],"HIF-1\u03b1-independent":[184],"pathway":[185,221],"also":[187,215],"involved":[188],"regulation.":[191],"results":[193],"showed":[194],"executes":[197],"its":[198],"through":[203],"regulating":[204],"ERR\u03b1":[205],"but":[206],"not":[207],"PPARGC1A":[208],"A2780/CP70":[212],"cells.":[213,232],"identified":[216],"cMyc/p21":[217],"novel":[220],"inhibitory":[224],"angio-prevention":[241,267],"information":[248],"obtained":[250],"As":[257],"dietary":[259],"flavonoid,":[260],"good":[264],"candidate":[265],"primary":[269],"prevention":[270],"cancers,":[273],"it":[275],"deserves":[276],"investigation":[278],"animal":[280],"studies":[281],"trials.":[284],"Citation":[285],"Format:":[286],"{Authors}.":[287],"{Abstract":[288],"title}":[289],"[abstract].":[290],"In:":[291],"Proceedings":[292],"101st":[295],"Annual":[296],"Meeting":[297],"American":[300],"Association":[301],"Cancer":[303,313],"Research;":[304],"2010":[305],"Apr":[306],"17-21;":[307],"Washington,":[308],"DC.":[309],"Philadelphia":[310],"(PA):":[311],"AACR;":[312],"Res":[314],"2010;70(8":[315],"Suppl):Abstract":[316],"nr":[317],"340.":[318]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}