{"id":"https://openalex.org/W2047923399","doi":"https://doi.org/10.1007/s11684-009-0038-1","title":"Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer","display_name":"Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer","publication_year":2009,"publication_date":"2009-04-20","ids":{"openalex":"https://openalex.org/W2047923399","doi":"https://doi.org/10.1007/s11684-009-0038-1","mag":"2047923399"},"language":"en","primary_location":{"id":"doi:10.1007/s11684-009-0038-1","doi":"https://doi.org/10.1007/s11684-009-0038-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11684-009-0038-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210177422","display_name":"Frontiers of Medicine","issn_l":"1673-7342","issn":["1673-7342","1673-7458","2095-0217","2095-0225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311889","host_organization_name":"Higher Education Press","host_organization_lineage":["https://openalex.org/P4310311889"],"host_organization_lineage_names":["Higher Education Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers of Medicine in China","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101417852","display_name":"Lihui Wang","orcid":"https://orcid.org/0000-0001-8960-8642","observed_orcids":["https://orcid.org/0000-0001-8960-8642"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihui Wang","raw_affiliation_strings":["Department of Pathology, Dalian Medical University, Dalian, 116044, China","Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"Dalian Medical University","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103093504","display_name":"Lianhong Li","orcid":"https://orcid.org/0000-0003-0238-3845","observed_orcids":["https://orcid.org/0000-0003-0238-3845"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lianhong Li","raw_affiliation_strings":["Department of Pathology, Dalian Medical University, Dalian, 116044, China","Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"Dalian Medical University","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112125989","display_name":"Shen Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shen Lv","raw_affiliation_strings":["Center Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China","The second affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]},{"raw_affiliation_string":"The second affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071687930","display_name":"Shujun Fan","orcid":"https://orcid.org/0000-0002-3570-4484","observed_orcids":["https://orcid.org/0000-0002-3570-4484"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujun Fan","raw_affiliation_strings":["Department of Pathology, Dalian Medical University, Dalian, 116044, China","Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"Dalian Medical University","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349203","display_name":"Zhan Li","orcid":"https://orcid.org/0000-0003-1658-2378","observed_orcids":["https://orcid.org/0000-0003-1658-2378"]},"institutions":[{"id":"https://openalex.org/I4210131579","display_name":"Dalian Maternal and Child Health Hospital","ror":"https://ror.org/03aqtjw04","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhan","raw_affiliation_strings":["Department of Pathology, Dalian Maternity Hospital, Dalian, 116012, China","Dalian Maternity Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Maternity Hospital, Dalian, 116012, China","institution_ids":[]},{"raw_affiliation_string":"Dalian Maternity Hospital","institution_ids":["https://openalex.org/I4210131579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063446205","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0001-9234-035X","observed_orcids":["https://orcid.org/0000-0001-9234-035X"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Wang","raw_affiliation_strings":["Department of Pathology, Dalian Medical University, Dalian, 116044, China","Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"Dalian Medical University","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"last","author":{"id":null,"display_name":"Zhong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhong Zhang","raw_affiliation_strings":["Department of Pathology, Dalian Medical University, Dalian, 116044, China","Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"Dalian Medical University","institution_ids":["https://openalex.org/I191996457"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103093504"],"corresponding_institution_ids":["https://openalex.org/I191996457"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1860283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"2","first_page":"164","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9959999918937683},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":1.0},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.9369999766349792},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.9739999771118164},{"id":"https://openalex.org/keywords/histological-grade","display_name":"histological grade","score":0.9150000214576721},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7052381038665771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6152998208999634},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6081934571266174},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5958071947097778},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48451846837997437},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.44644075632095337},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42751413583755493},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4244728088378906},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.42393332719802856},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4108906388282776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40312299132347107},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38471436500549316}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s11684-009-0038-1","doi":"https://doi.org/10.1007/s11684-009-0038-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11684-009-0038-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210177422","display_name":"Frontiers of Medicine","issn_l":"1673-7342","issn":["1673-7342","1673-7458","2095-0217","2095-0225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311889","host_organization_name":"Higher Education Press","host_organization_lineage":["https://openalex.org/P4310311889"],"host_organization_lineage_names":["Higher Education Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers of Medicine in China","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1580211231","https://openalex.org/W1988723336","https://openalex.org/W1990933115","https://openalex.org/W2011502034","https://openalex.org/W2028118323","https://openalex.org/W2030714746","https://openalex.org/W2033601733","https://openalex.org/W2040964625","https://openalex.org/W2061257207","https://openalex.org/W2068434239","https://openalex.org/W2072084871","https://openalex.org/W2092272303","https://openalex.org/W2095022603","https://openalex.org/W2117225268","https://openalex.org/W2125381755","https://openalex.org/W2127121861","https://openalex.org/W2129185399","https://openalex.org/W2139647802","https://openalex.org/W2140551998","https://openalex.org/W2142739240","https://openalex.org/W2146530991","https://openalex.org/W2147469407","https://openalex.org/W2157877775","https://openalex.org/W2160738204"],"related_works":["https://openalex.org/W2378318049","https://openalex.org/W2350833341","https://openalex.org/W2384155104","https://openalex.org/W2394362571","https://openalex.org/W1976233203","https://openalex.org/W2001517548","https://openalex.org/W2008382887","https://openalex.org/W2362417897","https://openalex.org/W1998521388","https://openalex.org/W149191670"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}