{"id":"https://openalex.org/W2047915768","doi":"https://doi.org/10.1161/strokeaha.110.594069","title":"Personalized Approaches to Clopidogrel Therapy","display_name":"Personalized Approaches to Clopidogrel Therapy","publication_year":2010,"publication_date":"2010-10-29","ids":{"openalex":"https://openalex.org/W2047915768","doi":"https://doi.org/10.1161/strokeaha.110.594069","mag":"2047915768","pmid":"https://pubmed.ncbi.nlm.nih.gov/21030701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3014683"},"language":"en","primary_location":{"id":"doi:10.1161/strokeaha.110.594069","doi":"https://doi.org/10.1161/strokeaha.110.594069","is_oa":true,"landing_page_url":"https://doi.org/10.1161/strokeaha.110.594069","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.110.594069","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.110.594069","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006140547","display_name":"Christopher D. Anderson","orcid":"https://orcid.org/0000-0002-0053-2002","observed_orcids":["https://orcid.org/0000-0002-0053-2002","https://orcid.org/0000-0002-3856-9775"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Anderson","raw_affiliation_strings":["From the Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research (C.D.A., A.B., J.R.), and the Hemorrhagic Stroke Research Program (C.D.A., A.B., S.M.G., J.R.), Massachusetts General Hospital, Boston, Mass; and Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research (C.D.A., A.B., J.R.), and the Hemorrhagic Stroke Research Program (C.D.A., A.B., S.M.G., J.R.), Massachusetts General Hospital, Boston, Mass; and Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042119710","display_name":"Alessandro Biffi","orcid":"https://orcid.org/0000-0001-7063-455X","observed_orcids":["https://orcid.org/0000-0001-7063-455X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandro Biffi","raw_affiliation_strings":["From the Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research (C.D.A., A.B., J.R.), and the Hemorrhagic Stroke Research Program (C.D.A., A.B., S.M.G., J.R.), Massachusetts General Hospital, Boston, Mass; and Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research (C.D.A., A.B., J.R.), and the Hemorrhagic Stroke Research Program (C.D.A., A.B., S.M.G., J.R.), Massachusetts General Hospital, Boston, Mass; and Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063509357","display_name":"Steven Mark Greenberg","orcid":"https://orcid.org/0000-0003-1792-8887","observed_orcids":["https://orcid.org/0000-0003-1792-8887"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Greenberg","raw_affiliation_strings":["From the Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research (C.D.A., A.B., J.R.), and the Hemorrhagic Stroke Research Program (C.D.A., A.B., S.M.G., J.R.), Massachusetts General Hospital, Boston, Mass; and Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research (C.D.A., A.B., J.R.), and the Hemorrhagic Stroke Research Program (C.D.A., A.B., S.M.G., J.R.), Massachusetts General Hospital, Boston, Mass; and Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006664647","display_name":"Jonathan M. Rosand","orcid":"https://orcid.org/0000-0002-1014-9138","observed_orcids":["https://orcid.org/0000-0002-1014-9138"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Rosand","raw_affiliation_strings":["From the Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research (C.D.A., A.B., J.R.), and the Hemorrhagic Stroke Research Program (C.D.A., A.B., S.M.G., J.R.), Massachusetts General Hospital, Boston, Mass; and Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research (C.D.A., A.B., J.R.), and the Hemorrhagic Stroke Research Program (C.D.A., A.B., S.M.G., J.R.), Massachusetts General Hospital, Boston, Mass; and Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics (C.D.A., A.B., J.R.), Broad Institute, Cambridge, Mass","institution_ids":["https://openalex.org/I107606265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3288,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.92700991,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"41","issue":"12","first_page":"2997","last_page":"3002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cyp2c19-polymorphism","display_name":"CYP2C19 polymorphism","score":0.8270000219345093},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.7269999980926514},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.6930000185966492},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.7400000095367432},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.7639999985694885},{"id":"https://openalex.org/keywords/antithrombotic-therapy","display_name":"antithrombotic therapy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/fda-advisory","display_name":"FDA advisory","score":0.5590000152587891},{"id":"https://openalex.org/keywords/clinical-decision-making","display_name":"clinical decision-making","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.9746500253677368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9322699308395386},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.6294710636138916},{"id":"https://openalex.org/C140840227","wikidata":"https://www.wikidata.org/wiki/Q3737532","display_name":"CYP2C19","level":4,"score":0.6138873100280762},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.5786423683166504},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5192654132843018},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4921940863132477},{"id":"https://openalex.org/C2781025758","wikidata":"https://www.wikidata.org/wiki/Q421704","display_name":"Proton-pump inhibitor","level":2,"score":0.4340362846851349},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42907679080963135},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.4177253842353821},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36215636134147644},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3382510542869568},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3117154836654663},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.19245857000350952},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.18967494368553162},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07218530774116516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D065731","descriptor_name":"Cytochrome P-450 CYP2C19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/strokeaha.110.594069","doi":"https://doi.org/10.1161/strokeaha.110.594069","is_oa":true,"landing_page_url":"https://doi.org/10.1161/strokeaha.110.594069","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.110.594069","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:21030701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21030701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3014683","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3014683","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stroke","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.954.129","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.954.129","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://stroke.ahajournals.org/content/41/12/2997.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1161/strokeaha.110.594069","doi":"https://doi.org/10.1161/strokeaha.110.594069","is_oa":true,"landing_page_url":"https://doi.org/10.1161/strokeaha.110.594069","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.110.594069","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6083057466","display_name":"Gene Discovery for Warfarin-Related Intracerebral Hemorrhage","funder_award_id":"R01NS059727","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2047915768.pdf","grobid_xml":"https://content.openalex.org/works/W2047915768.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1553345686","https://openalex.org/W1969022685","https://openalex.org/W1981102487","https://openalex.org/W1985059672","https://openalex.org/W2004298071","https://openalex.org/W2006941946","https://openalex.org/W2007108997","https://openalex.org/W2014040422","https://openalex.org/W2021241943","https://openalex.org/W2039527993","https://openalex.org/W2052922809","https://openalex.org/W2053379248","https://openalex.org/W2062345376","https://openalex.org/W2076350004","https://openalex.org/W2085817407","https://openalex.org/W2096219546","https://openalex.org/W2102393690","https://openalex.org/W2113787373","https://openalex.org/W2117933369","https://openalex.org/W2135575592","https://openalex.org/W2140220482","https://openalex.org/W2140319544","https://openalex.org/W2140333195","https://openalex.org/W2143777566","https://openalex.org/W2144766297","https://openalex.org/W2145218953","https://openalex.org/W2152376036","https://openalex.org/W2153837110","https://openalex.org/W2154940301","https://openalex.org/W2159858918","https://openalex.org/W2209519262","https://openalex.org/W4249056819"],"related_works":["https://openalex.org/W7100929723","https://openalex.org/W3092137835","https://openalex.org/W2153837110","https://openalex.org/W1979048116","https://openalex.org/W1859232251","https://openalex.org/W2154036717","https://openalex.org/W2486568529","https://openalex.org/W2112017122","https://openalex.org/W2275587608","https://openalex.org/W1820818428"],"abstract_inverted_index":{"Clopidogrel":[0],"is":[1,36],"one":[2],"of":[3,25,102,122,142],"the":[4,13,23,37,77,139],"most":[5],"commonly":[6],"prescribed":[7,85],"medications":[8],"worldwide.":[9],"Recent":[10],"advisories":[11,111],"from":[12],"US":[14],"Food":[15,107],"and":[16,42,52,105,108,112,120],"Drug":[17,109],"Administration":[18,110],"have":[19],"drawn":[20],"attention":[21],"to":[22,131,135],"possibility":[24],"personalized":[26],"decision-making":[27,99],"for":[28,33,97,117],"people":[29],"who":[30],"are":[31],"candidates":[32],"clopidogrel.":[34,80],"As":[35],"case":[38],"with":[39,67,88],"antihypertensives,":[40],"statins,":[41],"warfarin,":[43],"common":[44],"genetic":[45,59,115],"sequence":[46],"variants":[47,60],"can":[48],"influence":[49],"clopidogrel":[50],"metabolism":[51],"its":[53,92],"effect":[54],"on":[55],"platelet":[56],"activity.":[57],"These":[58],"have,":[61],"in":[62,86,100],"multiple":[63],"studies,":[64],"been":[65],"associated":[66],"adverse":[68],"clinical":[69],"outcomes.":[70],"Concurrent":[71],"medication":[72],"use":[73],"also":[74],"influences":[75],"how":[76],"body":[78],"handles":[79],"Proton":[81],"pump":[82,124],"inhibitors,":[83],"widely":[84],"conjunction":[87],"clopidogrel,":[89],"may":[90],"blunt":[91],"effectiveness.":[93],"We":[94],"address":[95],"implications":[96],"bedside":[98],"light":[101],"accumulated":[103],"data":[104],"current":[106,140],"conclude":[113],"that":[114],"testing":[116],"CYP2C19":[118],"genotype":[119],"limitation":[121],"proton":[123],"inhibitor":[125],"interactions":[126],"do":[127],"not":[128],"yet":[129],"appear":[130],"offer":[132],"an":[133],"opportunity":[134],"optimize":[136],"treatment":[137],"given":[138],"state":[141],"knowledge.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}