{"id":"https://openalex.org/W2047869488","doi":"https://doi.org/10.1021/la0204794","title":"Redox Properties of CytochromecAdsorbed on Self-Assembled Monolayers: A Probe for Protein Conformation and Orientation","display_name":"Redox Properties of CytochromecAdsorbed on Self-Assembled Monolayers: A Probe for Protein Conformation and Orientation","publication_year":2002,"publication_date":"2002-08-03","ids":{"openalex":"https://openalex.org/W2047869488","doi":"https://doi.org/10.1021/la0204794","mag":"2047869488"},"language":"en","primary_location":{"id":"doi:10.1021/la0204794","doi":"https://doi.org/10.1021/la0204794","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la0204794","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042011557","display_name":"Xiaoxi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxi Chen","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068073968","display_name":"Rosaria Ferrigno","orcid":"https://orcid.org/0000-0001-7005-5574","observed_orcids":["https://orcid.org/0000-0001-7005-5574"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosaria Ferrigno","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047600505","display_name":"Jerry Yang","orcid":"https://orcid.org/0000-0002-8423-7376","observed_orcids":["https://orcid.org/0000-0002-8423-7376","https://orcid.org/0009-0008-6372-2269"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Yang","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051537916","display_name":"George M. Whitesides","orcid":"https://orcid.org/0000-0001-9451-2442","observed_orcids":["https://orcid.org/0000-0001-9451-2442","https://orcid.org/0000-0003-1184-6573"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George M. Whitesides","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051537916"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":10.4869,"has_fulltext":false,"cited_by_count":184,"citation_normalized_percentile":{"value":0.98493003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"18","issue":"18","first_page":"7009","last_page":"7015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10913","display_name":"Molecular Junctions and Nanostructures","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10913","display_name":"Molecular Junctions and Nanostructures","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.26249998807907104,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12285","display_name":"Surface Chemistry and Catalysis","score":0.06469999998807907,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9980000257492065},{"id":"https://openalex.org/keywords/self-assembled-monolayers","display_name":"self-assembled monolayers","score":0.9860000014305115},{"id":"https://openalex.org/keywords/protein-adsorption","display_name":"protein adsorption","score":0.7559999823570251},{"id":"https://openalex.org/keywords/redox-potential","display_name":"redox potential","score":0.8939999938011169},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/protein-orientation","display_name":"protein orientation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/electron-transfer-kinetics","display_name":"electron transfer kinetics","score":0.734000027179718},{"id":"https://openalex.org/keywords/gold-electrode","display_name":"gold electrode","score":0.574999988079071},{"id":"https://openalex.org/keywords/mixed-self-assembled-monolayers","display_name":"mixed self-assembled monolayers","score":0.800000011920929},{"id":"https://openalex.org/keywords/sulfonate-groups","display_name":"sulfonate groups","score":0.6859999895095825},{"id":"https://openalex.org/keywords/surface-plasmon-resonance","display_name":"surface plasmon resonance","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8465527296066284},{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.7668143510818481},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.7641143202781677},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.600038468837738},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.5964083671569824},{"id":"https://openalex.org/C131649739","wikidata":"https://www.wikidata.org/wiki/Q1121115","display_name":"Self-assembled monolayer","level":3,"score":0.5673696994781494},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.5495301485061646},{"id":"https://openalex.org/C123669783","wikidata":"https://www.wikidata.org/wiki/Q902898","display_name":"Electron transfer","level":2,"score":0.5283628106117249},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.4549621045589447},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.442484974861145},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.37554702162742615},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3240601420402527},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.2813834547996521},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.2219122052192688},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.19637009501457214},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18464171886444092},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/la0204794","doi":"https://doi.org/10.1021/la0204794","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la0204794","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1968300400","https://openalex.org/W1973782096","https://openalex.org/W1974311832","https://openalex.org/W1977054660","https://openalex.org/W1977336508","https://openalex.org/W1978922517","https://openalex.org/W1980147989","https://openalex.org/W1987220178","https://openalex.org/W1991072674","https://openalex.org/W1992607822","https://openalex.org/W1995829317","https://openalex.org/W2009377140","https://openalex.org/W2013186818","https://openalex.org/W2015417844","https://openalex.org/W2023135802","https://openalex.org/W2024004515","https://openalex.org/W2032888181","https://openalex.org/W2035737042","https://openalex.org/W2036185289","https://openalex.org/W2043778762","https://openalex.org/W2045050155","https://openalex.org/W2048526989","https://openalex.org/W2051987868","https://openalex.org/W2058776928","https://openalex.org/W2058794895","https://openalex.org/W2065236128","https://openalex.org/W2065994977","https://openalex.org/W2069514224","https://openalex.org/W2070652142","https://openalex.org/W2072100248","https://openalex.org/W2072235334","https://openalex.org/W2074631701","https://openalex.org/W2079347827","https://openalex.org/W2087172103","https://openalex.org/W2095216354","https://openalex.org/W2105202307","https://openalex.org/W2123342482","https://openalex.org/W2134130835","https://openalex.org/W2149482213","https://openalex.org/W2169950904","https://openalex.org/W2950121550","https://openalex.org/W4214619664","https://openalex.org/W4300588846"],"related_works":["https://openalex.org/W4403337891","https://openalex.org/W2082914887","https://openalex.org/W1985496466","https://openalex.org/W1971943723","https://openalex.org/W2116276483","https://openalex.org/W1971604415","https://openalex.org/W2510570018","https://openalex.org/W2018700232","https://openalex.org/W1976368994","https://openalex.org/W2951332476"],"abstract_inverted_index":{"The":[0,63,90],"redox":[1,64,91,157],"behavior":[2],"of":[3,66,72,83,93,99,167,179,187,208,229,246,269],"cytochrome":[4],"c":[5,7,68,86,95,146,163,189,199,223],"(cyt":[6],")":[8,52,61,220],"adsorbed":[9,69,96,164,182,200,224,271],"to":[10,79,130,243],"gold":[11],"electrodes":[12],"modified":[13],"with":[14],"self-assembled":[15],"monolayers":[16],"(SAMs)":[17],"depends":[18],"on":[19,70,97,151,153,165,201,225,272],"the":[20,80,108,122,177,206,244,247,251,265],"SAM.":[21],"This":[22,253],"paper":[23],"examines":[24],"SAMs":[25,71,98,166,178,192,203],"generated":[26],"from":[27,55,107,205],"alkanethiols":[28],"terminating":[29],"in":[30,88,137,239],"trimethylammonium":[31],"(":[32,36,40,44,50,59],"1":[33,73,209,230],"),":[34,38,42,46],"sulfonate":[35,248],"2":[37,180,211],"methyl":[39],"3":[41],"amine":[43],"4":[45],"and":[47,54,74,102,111,210,267],"carboxylic":[48],"acid":[49],"5":[51,75],"groups":[53,249],"an":[56],"aromatic":[57],"thiol":[58],"6":[60,103],".":[62,190],"potentials":[65,92],"cyt":[67,85,94,145,162,188,198,222],"are":[76,104],"relatively":[77],"close":[78],"formal":[81,109,123],"potential":[82,124],"native":[84],"measured":[87],"solution.":[89],"3,":[100],"4,":[101],"significantly":[105,150,213],"shifted":[106],"potential,":[110],"a":[112,127,131,184,226,261],"reduction":[113],"peak":[114],"at":[115,250],"about":[116],"0.5":[117],"V":[118],"more":[119,132],"negative":[120],"than":[121,221],"(that":[125],"is,":[126],"value":[128],"corresponding":[129],"difficult":[133],"reduction)":[134],"was":[135],"observed":[136,160],"all":[138],"three":[139],"cases.":[140],"These":[141,235],"observations":[142,236],"suggest":[143,237],"that":[144,176,256],"changes":[147,238],"its":[148],"conformation":[149,266],"adsorption":[152],"these":[154],"surfaces.":[155,273],"No":[156],"peaks":[158],"were":[159,193],"for":[161,264],"2,":[168],"although":[169],"surface":[170],"plasmon":[171],"resonance":[172],"(SPR)":[173],"studies":[174],"indicate":[175],"irreversibly":[181],"approximately":[183],"double":[185],"layer":[186],"Mixed":[191],"also":[194],"studied.":[195],"Most":[196],"interestingly,":[197],"mixed":[202],"formed":[204],"combinations":[207],"exhibited":[212],"slower":[214],"electron":[215],"transfer":[216],"(0.3\u22121.2":[217],"s":[218,232],"-1":[219,233],"homogeneous":[227],"SAM":[228],"(45":[231],").":[234],"protein":[240,270],"orientation":[241,268],"due":[242],"presence":[245],"interface.":[252],"study":[254],"suggests":[255],"electrochemical":[257],"measurement":[258],"can":[259],"be":[260],"useful":[262],"probe":[263]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}