{"id":"https://openalex.org/W2047868675","doi":"https://doi.org/10.1186/cc7704","title":"Extending international sepsis epidemiology: the impact of organ dysfunction","display_name":"Extending international sepsis epidemiology: the impact of organ dysfunction","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2047868675","doi":"https://doi.org/10.1186/cc7704","mag":"2047868675","pmid":"https://pubmed.ncbi.nlm.nih.gov/19291262","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2688124"},"language":"en","primary_location":{"id":"doi:10.1186/cc7704","doi":"https://doi.org/10.1186/cc7704","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc7704","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc7704","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc7704","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033722690","display_name":"Annette M. Esper","orcid":"https://orcid.org/0000-0002-2104-3523","observed_orcids":["https://orcid.org/0000-0002-2104-3523"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Annette M Esper","raw_affiliation_strings":["Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, GA 30303, USA. aesper@emory.edu","Division of Pulmonary, Allergy, and Critical Care, Emory University School of Medicine, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, GA 30303, USA. aesper@emory.edu","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care, Emory University School of Medicine, Atlanta, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031081653","display_name":"Greg S. Martin","orcid":"https://orcid.org/0000-0002-9684-7593","observed_orcids":["https://orcid.org/0000-0002-9684-7593"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg S Martin","raw_affiliation_strings":["Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, 49 Jesse Hill Jr Drive [FOB], Atlanta, GA, 30303, USA","Division of Pulmonary, Allergy, and Critical Care, Emory University School of Medicine, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, 49 Jesse Hill Jr Drive [FOB], Atlanta, GA, 30303, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care, Emory University School of Medicine, Atlanta, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033722690"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.5668,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.83963012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"120","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.9079999923706055},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.9070000052452087},{"id":"https://openalex.org/keywords/sepsis-mortality","display_name":"sepsis mortality","score":0.953000009059906},{"id":"https://openalex.org/keywords/chronic-comorbidities","display_name":"chronic comorbidities","score":0.8629999756813049},{"id":"https://openalex.org/keywords/sofa-score","display_name":"SOFA score","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sepsis-incidence","display_name":"sepsis incidence","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sepsis-treatment","display_name":"sepsis treatment","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.8816994428634644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8647979497909546},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8392456769943237},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7366465330123901},{"id":"https://openalex.org/C2780835948","wikidata":"https://www.wikidata.org/wiki/Q1193870","display_name":"Multiple organ dysfunction syndrome","level":3,"score":0.7243056297302246},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5814237594604492},{"id":"https://openalex.org/C3018799218","wikidata":"https://www.wikidata.org/wiki/Q188193","display_name":"Organ system","level":3,"score":0.5265588760375977},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4965205788612366},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.4218378961086273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21838536858558655},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10301381349563599},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D038622","descriptor_name":"Internationality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/cc7704","doi":"https://doi.org/10.1186/cc7704","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc7704","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc7704","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2688124","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2688124","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"},{"id":"pmid:19291262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19291262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care (London, England)","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1186/cc7704","doi":"https://doi.org/10.1186/cc7704","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc7704","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc7704","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2047868675.pdf","grobid_xml":"https://content.openalex.org/works/W2047868675.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1972350167","https://openalex.org/W1982531963","https://openalex.org/W1990243957","https://openalex.org/W2007497300","https://openalex.org/W2049927822","https://openalex.org/W2054938569","https://openalex.org/W2085208748","https://openalex.org/W2095497639","https://openalex.org/W2103053257","https://openalex.org/W2108885025","https://openalex.org/W2118858814","https://openalex.org/W2145577370","https://openalex.org/W2164679816","https://openalex.org/W2346917707","https://openalex.org/W4230150188","https://openalex.org/W4239528954"],"related_works":["https://openalex.org/W2296662492","https://openalex.org/W2155185990","https://openalex.org/W2998334852","https://openalex.org/W7160905345","https://openalex.org/W2040529696","https://openalex.org/W2889953095","https://openalex.org/W2036127105","https://openalex.org/W4412414381","https://openalex.org/W2058383836","https://openalex.org/W2097473237"],"abstract_inverted_index":{"In":[0],"the":[1,18,30,36,49,79,91,101,117],"previous":[2],"issue":[3],"of":[4,15,21,38,45,51,67,93,103,119],"Critical":[5],"Care,":[6],"Blanco":[7],"and":[8,47,70,131],"colleagues":[9],"contributed":[10],"to":[11,82,90,100,126],"a":[12,42],"growing":[13],"body":[14],"literature":[16],"on":[17,116],"international":[19],"epidemiology":[20],"severe":[22],"sepsis.":[23,135],"Taken":[24],"together,":[25],"these":[26],"studies":[27,112],"confirm":[28],"that":[29,35,48,64,88,107],"sepsis":[31,97],"incidence":[32],"is":[33,41,54,62],"high,":[34],"development":[37,92,102],"organ":[39,52,68,73,94,128],"dysfunction":[40,53,69,74,95,129],"major":[43],"determinant":[44],"mortality":[46,133],"occurrence":[50],"influenced":[55],"by":[56],"chronic":[57],"comorbid":[58],"medical":[59],"conditions.":[60],"It":[61],"clear":[63],"early":[65],"detection":[66],"serial":[71],"sequential":[72],"scoring":[75],"provides":[76],"us":[77],"with":[78],"best":[80],"chance":[81],"optimize":[83],"clinical":[84],"care.":[85],"Identifying":[86],"factors":[87],"contribute":[89],"in":[96,134],"will":[98,108],"lead":[99],"new":[104,120],"treatment":[105,121],"modalities":[106,122],"reduce":[109],"mortality.":[110],"Future":[111],"must":[113],"therefore":[114],"focus":[115],"impact":[118],"for":[123],"preventing":[124],"progression":[125],"multiple":[127],"syndrome":[130],"consequent":[132]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}