{"id":"https://openalex.org/W2047852246","doi":"https://doi.org/10.1212/wnl.38.5.730","title":"Resolving metabolic abnormalities in a case of pure alexia","display_name":"Resolving metabolic abnormalities in a case of pure alexia","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W2047852246","doi":"https://doi.org/10.1212/wnl.38.5.730","mag":"2047852246","pmid":"https://pubmed.ncbi.nlm.nih.gov/3258969"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.38.5.730","doi":"https://doi.org/10.1212/wnl.38.5.730","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.38.5.730","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025115314","display_name":"Frank L. Silver","orcid":"https://orcid.org/0000-0002-7569-8429","observed_orcids":["https://orcid.org/0000-0002-7569-8429"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. L. Silver","raw_affiliation_strings":["From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108496191","display_name":"J. B. Chawluk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. B. Chawluk","raw_affiliation_strings":["From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091018344","display_name":"Thomas M. Bosley","orcid":"https://orcid.org/0000-0003-0567-3709","observed_orcids":["https://orcid.org/0000-0003-0567-3709"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. M. Bosley","raw_affiliation_strings":["From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Rosen","raw_affiliation_strings":["From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054139074","display_name":"Robert Dann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Dann","raw_affiliation_strings":["From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041017090","display_name":"Robert C. Sergott","orcid":"https://orcid.org/0000-0001-6926-124X","observed_orcids":["https://orcid.org/0000-0001-6926-124X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. C. Sergott","raw_affiliation_strings":["From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088003622","display_name":"Abass A. Alavi","orcid":"https://orcid.org/0000-0002-2442-7901","observed_orcids":["https://orcid.org/0000-0002-2442-7901"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Alavi","raw_affiliation_strings":["From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110236686","display_name":"Martin Reivich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Reivich","raw_affiliation_strings":["From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cerebrovascular Research Center, Department of Neurology, and Department of Radiology (Dr. Alavi), University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.31462557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"38","issue":"5","first_page":"730","last_page":"730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10103","display_name":"Reading and Literacy Development","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10103","display_name":"Reading and Literacy Development","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10465","display_name":"Neurobiology of Language and Bilingualism","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pure-alexia","display_name":"pure alexia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lateral-geniculate-nucleus","display_name":"lateral geniculate nucleus","score":0.8349999785423279},{"id":"https://openalex.org/keywords/splenium-of-corpus-callosum","display_name":"splenium of corpus callosum","score":0.9409999847412109},{"id":"https://openalex.org/keywords/acute-cerebral-infarction","display_name":"acute cerebral infarction","score":0.7870000004768372},{"id":"https://openalex.org/keywords/local-cerebral-glucose-metabolism","display_name":"local cerebral glucose metabolism","score":0.718999981880188},{"id":"https://openalex.org/keywords/18f-fdg-pet","display_name":"18F-FDG PET","score":0.7829999923706055},{"id":"https://openalex.org/keywords/interhemispheric-disconnection","display_name":"interhemispheric disconnection","score":0.746999979019165},{"id":"https://openalex.org/keywords/visual-word-recognition","display_name":"visual word recognition","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2776643646","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Splenium","level":4,"score":0.9899278283119202},{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.8892781138420105},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.5482722520828247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5375878810882568},{"id":"https://openalex.org/C2780371621","wikidata":"https://www.wikidata.org/wiki/Q3709910","display_name":"Disconnection","level":2,"score":0.530364990234375},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.4668019115924835},{"id":"https://openalex.org/C2779450755","wikidata":"https://www.wikidata.org/wiki/Q1209150","display_name":"Cerebral infarction","level":3,"score":0.45935937762260437},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.45173320174217224},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.43016767501831055},{"id":"https://openalex.org/C2778046553","wikidata":"https://www.wikidata.org/wiki/Q848340","display_name":"Occipital lobe","level":2,"score":0.41343623399734497},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3346601724624634},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33446335792541504},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33109018206596375},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2786124348640442},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2650637626647949},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.2541195750236511},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.23693567514419556},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.09351235628128052},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.08693966269493103},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.053458571434020996},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004411","descriptor_name":"Dyslexia, Acquired","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004411","descriptor_name":"Dyslexia, Acquired","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004411","descriptor_name":"Dyslexia, Acquired","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.38.5.730","doi":"https://doi.org/10.1212/wnl.38.5.730","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.38.5.730","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:3258969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3258969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G671828561","display_name":null,"funder_award_id":"NS 14867","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1968477693","https://openalex.org/W2087592348","https://openalex.org/W2100065845","https://openalex.org/W2313650123","https://openalex.org/W2094261358","https://openalex.org/W2021460529","https://openalex.org/W2060578029","https://openalex.org/W2023361864","https://openalex.org/W1876795884","https://openalex.org/W2076763344"],"abstract_inverted_index":{"We":[0],"report":[1],"resolving":[2],"metabolic":[3,75],"abnormalities":[4],"corresponding":[5],"to":[6,16,36],"clinical":[7],"improvement":[8],"in":[9,86,101,113],"a":[10,46],"patient":[11],"with":[12,27],"pure":[13,105],"alexia":[14],"secondary":[15],"acute":[17],"cerebral":[18,21,97,117],"infarction.":[19,92],"Local":[20],"glucose":[22],"metabolism":[23],"(lCMRgl)":[24],"was":[25],"measured":[26],"positron":[28],"emission":[29],"tomography":[30],"(PET)":[31],"using":[32],"18F-fluorodeoxyglucose":[33],"(18F-FDG)":[34],"close":[35],"ictus":[37],"and":[38,45,62,82],"4":[39],"1/2":[40],"months":[41],"later.":[42],"Serial":[43],"CTs":[44],"subsequent":[47],"MRI":[48],"demonstrated":[49,70],"small,":[50],"unchanging":[51],"left-hemispheric":[52],"lesions":[53],"involving":[54],"the":[55,58,63,66,71,74,87,102,114],"area":[56],"of":[57,65,73,89,104,116],"lateral":[59],"geniculate":[60],"body":[61],"splenium":[64],"corpus":[67],"callosum.":[68],"PET":[69],"evolution":[72],"abnormality":[76],"resulting":[77],"from":[78],"intrahemispheric":[79],"(lateral":[80],"geniculate)":[81],"interhemispheric":[83],"(splenium)":[84],"disconnection":[85,98],"absence":[88,115],"occipital":[90],"lobe":[91],"This":[93],"case":[94],"illustrates":[95],"that":[96],"can":[99],"result":[100],"syndrome":[103],"alexia.":[106],"The":[107],"factors":[108],"accounting":[109],"for":[110],"focal":[111],"hypometabolism":[112],"infarction":[118],"are":[119],"discussed.":[120]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
