{"id":"https://openalex.org/W2047784454","doi":"https://doi.org/10.1016/0277-5379(91)90441-f","title":"Characterisation of a cell line (LCC-18) from a cultured human neuroendocrine-differentiated colonic carcinoma","display_name":"Characterisation of a cell line (LCC-18) from a cultured human neuroendocrine-differentiated colonic carcinoma","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W2047784454","doi":"https://doi.org/10.1016/0277-5379(91)90441-f","mag":"2047784454","pmid":"https://pubmed.ncbi.nlm.nih.gov/1782079"},"language":"en","primary_location":{"id":"doi:10.1016/0277-5379(91)90441-f","doi":"https://doi.org/10.1016/0277-5379(91)90441-f","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0277-5379(91)90441-f","pdf_url":null,"source":{"id":"https://openalex.org/S42075721","display_name":"European Journal of Cancer and Clinical Oncology","issn_l":"0277-5379","issn":["0277-5379","1878-5980"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104041612","display_name":"Monalill Lundqvist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]},{"id":"https://openalex.org/I4210133710","display_name":"Ludwig Cancer Research","ror":"https://ror.org/03gvptg28","country_code":"SE","type":"nonprofit","lineage":["https://openalex.org/I4210133710","https://openalex.org/I4210150094"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Monalill Lundqvist","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Clinical Branch, University Hospital, Uppsala, Sweden","Ludwig Institute for Cancer Research, Clinical Branch, University Hospital, 751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Clinical Branch, University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035","https://openalex.org/I4210133710"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Clinical Branch, University Hospital, 751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I4210133710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110117555","display_name":"Joachim Mark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joachim Mark","raw_affiliation_strings":["Department of Cytogenetics, KSS, Sk\u00f6vde, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytogenetics, KSS, Sk\u00f6vde, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067619304","display_name":"Keiko Funa","orcid":"https://orcid.org/0000-0003-2830-2273","observed_orcids":["https://orcid.org/0000-0003-2830-2273"]},"institutions":[{"id":"https://openalex.org/I4210133710","display_name":"Ludwig Cancer Research","ror":"https://ror.org/03gvptg28","country_code":"SE","type":"nonprofit","lineage":["https://openalex.org/I4210133710","https://openalex.org/I4210150094"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Keiko Funa","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Clinical Branch, University Hospital, 751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Clinical Branch, University Hospital, 751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I4210133710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111529594","display_name":"Nils\u2010Erik Heldin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Nils-Erik Heldin","raw_affiliation_strings":["Department of Pathology, University Hospital, 751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Hospital, 751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031949010","display_name":"George Morstyn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Morstyn","raw_affiliation_strings":["Melbourne Tumor Biology Branch, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne Tumor Biology Branch, Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036992741","display_name":"Barbro Wedell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbro Wedell","raw_affiliation_strings":["Department of Cytogenetics, KSS, Sk\u00f6vde, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytogenetics, KSS, Sk\u00f6vde, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110398287","display_name":"Judy Layton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judy Layton","raw_affiliation_strings":["Melbourne Tumor Biology Branch, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne Tumor Biology Branch, Melbourne, Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065246954","display_name":"Kjell \u00d6berg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133710","display_name":"Ludwig Cancer Research","ror":"https://ror.org/03gvptg28","country_code":"SE","type":"nonprofit","lineage":["https://openalex.org/I4210133710","https://openalex.org/I4210150094"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kjell \u00d6berg","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Clinical Branch, University Hospital, 751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Clinical Branch, University Hospital, 751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I4210133710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7185,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.74935885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"12","first_page":"1663","last_page":"1668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroendocrine-differentiation","display_name":"neuroendocrine differentiation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/synaptophysin","display_name":"synaptophysin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/vasoactive-intestinal-peptide","display_name":"vasoactive intestinal peptide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.9959999918937683},{"id":"https://openalex.org/keywords/myc-amplification","display_name":"MYC amplification","score":0.8790000081062317},{"id":"https://openalex.org/keywords/double-minute-chromosomes","display_name":"double minute chromosomes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hypotriploidy","display_name":"hypotriploidy","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2911142149","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colonic Carcinoma","level":3,"score":0.6587421298027039},{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.6549156308174133},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6539034247398376},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.635037899017334},{"id":"https://openalex.org/C2777209535","wikidata":"https://www.wikidata.org/wiki/Q14864388","display_name":"Synaptophysin","level":3,"score":0.6019873023033142},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.5602542757987976},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.5456888675689697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5424914360046387},{"id":"https://openalex.org/C2777858994","wikidata":"https://www.wikidata.org/wiki/Q10599959","display_name":"Neuroendocrine cell","level":3,"score":0.5134142637252808},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4818595349788666},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4739503860473633},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4667157530784607},{"id":"https://openalex.org/C2780341458","wikidata":"https://www.wikidata.org/wiki/Q18391873","display_name":"Neuroendocrine differentiation","level":4,"score":0.4663170278072357},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.45830750465393066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45554083585739136},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4430515766143799},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.44008031487464905},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.38215383887290955},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38037362694740295},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2569155693054199},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22170627117156982},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20573890209197998},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.15803396701812744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1449161171913147},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13198930025100708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12983083724975586},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.11400929093360901},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.06545251607894897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002276","descriptor_name":"Carcinoid Tumor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011923","descriptor_name":"Rats, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0277-5379(91)90441-f","doi":"https://doi.org/10.1016/0277-5379(91)90441-f","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0277-5379(91)90441-f","pdf_url":null,"source":{"id":"https://openalex.org/S42075721","display_name":"European Journal of Cancer and Clinical Oncology","issn_l":"0277-5379","issn":["0277-5379","1878-5980"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer and Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:1782079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1782079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cancer (Oxford, England : 1990)","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W589640607","https://openalex.org/W1496753269","https://openalex.org/W1566653130","https://openalex.org/W1574900767","https://openalex.org/W1844937435","https://openalex.org/W1964162053","https://openalex.org/W1976969187","https://openalex.org/W1990205754","https://openalex.org/W1997225984","https://openalex.org/W1997261857","https://openalex.org/W2017428584","https://openalex.org/W2056120923","https://openalex.org/W2064148637","https://openalex.org/W2064663732","https://openalex.org/W2073101093","https://openalex.org/W2076698025","https://openalex.org/W2078571162","https://openalex.org/W2092602709","https://openalex.org/W2115900262","https://openalex.org/W2134171548","https://openalex.org/W2136425070","https://openalex.org/W2146415791","https://openalex.org/W2209629509","https://openalex.org/W2334173351","https://openalex.org/W2339359539","https://openalex.org/W2397180243","https://openalex.org/W2415885146","https://openalex.org/W2417391081","https://openalex.org/W2419280460","https://openalex.org/W2419310701","https://openalex.org/W4240339288"],"related_works":["https://openalex.org/W3089290544","https://openalex.org/W2089120635","https://openalex.org/W1574900767","https://openalex.org/W2982040055","https://openalex.org/W2073101093","https://openalex.org/W7036697728","https://openalex.org/W2105959192","https://openalex.org/W2004109496","https://openalex.org/W2460626364","https://openalex.org/W2086638509"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}