{"id":"https://openalex.org/W2047707705","doi":"https://doi.org/10.1088/0960-1317/13/2/306","title":"Simulation of microfluidic pumping in a genomic DNA blood-processing cassette","display_name":"Simulation of microfluidic pumping in a genomic DNA blood-processing cassette","publication_year":2003,"publication_date":"2003-01-02","ids":{"openalex":"https://openalex.org/W2047707705","doi":"https://doi.org/10.1088/0960-1317/13/2/306","mag":"2047707705"},"language":"en","primary_location":{"id":"doi:10.1088/0960-1317/13/2/306","doi":"https://doi.org/10.1088/0960-1317/13/2/306","is_oa":true,"landing_page_url":"https://doi.org/10.1088/0960-1317/13/2/306","pdf_url":"https://iopscience.iop.org/article/10.1088/0960-1317/13/2/306/pdf","source":{"id":"https://openalex.org/S170809390","display_name":"Journal of Micromechanics and Microengineering","issn_l":"0960-1317","issn":["0960-1317","1361-6439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Micromechanics and Microengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iopscience.iop.org/article/10.1088/0960-1317/13/2/306/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michael T Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269518","display_name":"Cepheid (United States)","ror":"https://ror.org/04dz9ne83","country_code":"US","type":"company","lineage":["https://openalex.org/I4405269518"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T Taylor","raw_affiliation_strings":["Cepheid, 904 Caribbean Dr., Sunnyvale, CA 94089\u20131302, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cepheid, 904 Caribbean Dr., Sunnyvale, CA 94089\u20131302, USA","institution_ids":["https://openalex.org/I4405269518"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269518","display_name":"Cepheid (United States)","ror":"https://ror.org/04dz9ne83","country_code":"US","type":"company","lineage":["https://openalex.org/I4405269518"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Nguyen","raw_affiliation_strings":["Cepheid, 904 Caribbean Dr., Sunnyvale, CA 94089\u20131302, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cepheid, 904 Caribbean Dr., Sunnyvale, CA 94089\u20131302, USA","institution_ids":["https://openalex.org/I4405269518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081211132","display_name":"Jesus Ching","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269518","display_name":"Cepheid (United States)","ror":"https://ror.org/04dz9ne83","country_code":"US","type":"company","lineage":["https://openalex.org/I4405269518"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus Ching","raw_affiliation_strings":["Cepheid, 904 Caribbean Dr., Sunnyvale, CA 94089\u20131302, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cepheid, 904 Caribbean Dr., Sunnyvale, CA 94089\u20131302, USA","institution_ids":["https://openalex.org/I4405269518"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109977948","display_name":"K. Petersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269518","display_name":"Cepheid (United States)","ror":"https://ror.org/04dz9ne83","country_code":"US","type":"company","lineage":["https://openalex.org/I4405269518"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt E Petersen","raw_affiliation_strings":["Cepheid, 904 Caribbean Dr., Sunnyvale, CA 94089\u20131302, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cepheid, 904 Caribbean Dr., Sunnyvale, CA 94089\u20131302, USA","institution_ids":["https://openalex.org/I4405269518"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405269518"],"apc_list":{"value":3325,"currency":"USD","value_usd":3325},"apc_paid":null,"fwci":2.9956,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.90584728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"2","first_page":"201","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidic-pumping","display_name":"microfluidic pumping","score":0.8920000195503235},{"id":"https://openalex.org/keywords/diaphragm-pump","display_name":"diaphragm pump","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sample-preparation","display_name":"sample preparation","score":0.4729999899864197},{"id":"https://openalex.org/keywords/volumetric-flow-rate","display_name":"volumetric flow rate","score":0.8080000281333923},{"id":"https://openalex.org/keywords/pressure-measurement","display_name":"pressure measurement","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.9247987270355225},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.8461132645606995},{"id":"https://openalex.org/C172120300","wikidata":"https://www.wikidata.org/wiki/Q1134348","display_name":"Volumetric flow rate","level":2,"score":0.5045026540756226},{"id":"https://openalex.org/C90278072","wikidata":"https://www.wikidata.org/wiki/Q216320","display_name":"Fluid dynamics","level":2,"score":0.48202264308929443},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.4490995705127716},{"id":"https://openalex.org/C164292776","wikidata":"https://www.wikidata.org/wiki/Q5271779","display_name":"Diaphragm (acoustics)","level":3,"score":0.43497899174690247},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4270760715007782},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3364647626876831},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.330666184425354},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3113003075122833},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2942847013473511},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.24471911787986755},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.10881519317626953},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07879588007926941},{"id":"https://openalex.org/C157138929","wikidata":"https://www.wikidata.org/wiki/Q570","display_name":"Loudspeaker","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1088/0960-1317/13/2/306","doi":"https://doi.org/10.1088/0960-1317/13/2/306","is_oa":true,"landing_page_url":"https://doi.org/10.1088/0960-1317/13/2/306","pdf_url":"https://iopscience.iop.org/article/10.1088/0960-1317/13/2/306/pdf","source":{"id":"https://openalex.org/S170809390","display_name":"Journal of Micromechanics and Microengineering","issn_l":"0960-1317","issn":["0960-1317","1361-6439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Micromechanics and Microengineering","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1088/0960-1317/13/2/306","doi":"https://doi.org/10.1088/0960-1317/13/2/306","is_oa":true,"landing_page_url":"https://doi.org/10.1088/0960-1317/13/2/306","pdf_url":"https://iopscience.iop.org/article/10.1088/0960-1317/13/2/306/pdf","source":{"id":"https://openalex.org/S170809390","display_name":"Journal of Micromechanics and Microengineering","issn_l":"0960-1317","issn":["0960-1317","1361-6439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Micromechanics and Microengineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320332815","display_name":"Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2047707705.pdf","grobid_xml":"https://content.openalex.org/works/W2047707705.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1968989791","https://openalex.org/W1971875546","https://openalex.org/W2013117405","https://openalex.org/W2019014472","https://openalex.org/W2024251977","https://openalex.org/W2032215280","https://openalex.org/W2036807723","https://openalex.org/W2043672081","https://openalex.org/W2056584136","https://openalex.org/W2057936277","https://openalex.org/W2059824187","https://openalex.org/W2071311642","https://openalex.org/W2071368421","https://openalex.org/W2072551359","https://openalex.org/W2072576034","https://openalex.org/W2077106134","https://openalex.org/W2079112687","https://openalex.org/W2082183799","https://openalex.org/W2091718555","https://openalex.org/W2094691790","https://openalex.org/W2100785749","https://openalex.org/W2433705766","https://openalex.org/W2983363128"],"related_works":["https://openalex.org/W2024251977","https://openalex.org/W3146967241","https://openalex.org/W2967288414","https://openalex.org/W1997402934","https://openalex.org/W2105652666","https://openalex.org/W2080416055","https://openalex.org/W4232611425","https://openalex.org/W4400114868","https://openalex.org/W195763171","https://openalex.org/W2037210046"],"abstract_inverted_index":{"Microfluidic":[0],"cassettes":[1],"that":[2,137,150],"perform":[3],"integrated":[4],"biological":[5],"sample":[6,107],"preparation":[7],"and":[8,14,28,37,74,121,125,155,167,182],"DNA":[9],"analysis":[10],"require":[11],"fluidic":[12,35,60,86,111,140,169],"control":[13],"transport":[15],"mechanisms":[16],"built":[17],"into":[18],"the":[19,39,50,53,85,96,101,109,116,122,132,139,143,162,187],"device.":[20],"In":[21,81],"this":[22,58,180],"study,":[23],"pneumatically":[24],"actuated":[25],"diaphragm":[26,102,165],"pumps":[27],"valves":[29],"were":[30,93,115],"employed":[31],"to":[32,56,83,100,160,189],"achieve":[33],"precise":[34],"manipulation":[36],"enabled":[38,131],"execution":[40],"of":[41,52,95,134,164,179],"several":[42],"sample-processing":[43],"steps":[44],"within":[45],"a":[46,63,75,90,135,176,183],"single":[47],"cassette.":[48],"However,":[49],"design":[51],"microfluidic":[54,173],"cassette":[55],"accomplish":[57],"multi-step":[59],"protocol":[61],"required":[62],"complex":[64,172],"three-dimensional":[65],"fluid":[66,127,147],"path":[67],"through":[68,108,142],"valves,":[69],"bends,":[70],"various":[71],"sized":[72],"passageways":[73],"porous":[76],"filter":[77],"for":[78,192],"cell":[79],"capture.":[80],"order":[82],"understand":[84],"behavior":[87,163],"in":[88,171,186],"such":[89],"device,":[91],"measurements":[92],"taken":[94],"pneumatic":[97],"pressure":[98,156],"delivered":[99],"pump":[103],"as":[104],"it":[105],"pushed":[106],"complicated":[110],"pathway.":[112],"Simultaneously":[113],"monitored":[114],"resulting":[117,168],"volumetric":[118],"flow":[119,153],"rate,":[120],"corresponding":[123],"pre-":[124],"post-filter":[126],"pressures.":[128],"The":[129,158],"data":[130],"construction":[133],"model":[136],"simulated":[138],"action":[141],"device":[144],"using":[145],"established":[146],"mechanics":[148],"theory":[149],"closely":[151],"matched":[152],"rate":[154],"data.":[157],"ability":[159],"simulate":[161],"pumping":[166],"movements":[170],"devices":[174,191],"provides":[175],"greater":[177],"comprehension":[178],"phenomenon":[181],"useful":[184],"tool":[185],"application":[188],"future":[190],"biochemical":[193],"analysis.":[194]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}