{"id":"https://openalex.org/W2047659701","doi":"https://doi.org/10.1016/j.resp.2014.05.005","title":"Intermittent hypercapnia enhances CO2 responsiveness and overcomes serotonergic dysfunction","display_name":"Intermittent hypercapnia enhances CO2 responsiveness and overcomes serotonergic dysfunction","publication_year":2014,"publication_date":"2014-05-26","ids":{"openalex":"https://openalex.org/W2047659701","doi":"https://doi.org/10.1016/j.resp.2014.05.005","mag":"2047659701","pmid":"https://pubmed.ncbi.nlm.nih.gov/24874557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4167740"},"language":"en","primary_location":{"id":"doi:10.1016/j.resp.2014.05.005","doi":"https://doi.org/10.1016/j.resp.2014.05.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.resp.2014.05.005","pdf_url":null,"source":{"id":"https://openalex.org/S72042703","display_name":"Respiratory Physiology & Neurobiology","issn_l":"1569-9048","issn":["1569-9048","1878-1519"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Physiology &amp; Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4167740","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047477751","display_name":"Bryan Patrick Mosher","orcid":"https://orcid.org/0009-0001-1020-8273","observed_orcids":["https://orcid.org/0009-0001-1020-8273"]},"institutions":[{"id":"https://openalex.org/I141472210","display_name":"University of Alaska Fairbanks","ror":"https://ror.org/01j7nq853","country_code":"US","type":"education","lineage":["https://openalex.org/I141472210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan P. Mosher","raw_affiliation_strings":["University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States","institution_ids":["https://openalex.org/I141472210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033555817","display_name":"Barbara E. Taylor","orcid":"https://orcid.org/0000-0003-1635-6194","observed_orcids":["https://orcid.org/0000-0003-1635-6194"]},"institutions":[{"id":"https://openalex.org/I141472210","display_name":"University of Alaska Fairbanks","ror":"https://ror.org/01j7nq853","country_code":"US","type":"education","lineage":["https://openalex.org/I141472210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara E. Taylor","raw_affiliation_strings":["University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States; Institute of Arctic Biology, Fairbanks, AK, United States","Institute of Arctic Biology, Fairbanks, AK, United States","University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States; Institute of Arctic Biology, Fairbanks, AK, United States","institution_ids":["https://openalex.org/I141472210"]},{"raw_affiliation_string":"Institute of Arctic Biology, Fairbanks, AK, United States","institution_ids":[]},{"raw_affiliation_string":"University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States","institution_ids":["https://openalex.org/I141472210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040930218","display_name":"Michael B. Harris","orcid":"https://orcid.org/0000-0002-8172-3416","observed_orcids":["https://orcid.org/0000-0002-8172-3416"]},"institutions":[{"id":"https://openalex.org/I141472210","display_name":"University of Alaska Fairbanks","ror":"https://ror.org/01j7nq853","country_code":"US","type":"education","lineage":["https://openalex.org/I141472210"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael B. Harris","raw_affiliation_strings":["University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States; Institute of Arctic Biology, Fairbanks, AK, United States. Electronic address: mbharris@alaska.edu","Institute of Arctic Biology, Fairbanks, AK, United States","University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States; Institute of Arctic Biology, Fairbanks, AK, United States. Electronic address: mbharris@alaska.edu","institution_ids":["https://openalex.org/I141472210"]},{"raw_affiliation_string":"Institute of Arctic Biology, Fairbanks, AK, United States","institution_ids":[]},{"raw_affiliation_string":"University of Alaska Fairbanks, Biology and Wildlife Department, Fairbanks, AK, United States","institution_ids":["https://openalex.org/I141472210"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040930218"],"corresponding_institution_ids":["https://openalex.org/I141472210"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":0.4483,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57174589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"200","issue":null,"first_page":"33","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-chemosensitivity","display_name":"central chemosensitivity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/serotonergic-dysfunction","display_name":"serotonergic dysfunction","score":0.8980000019073486},{"id":"https://openalex.org/keywords/raphe-nuclei","display_name":"raphe nuclei","score":0.6660000085830688},{"id":"https://openalex.org/keywords/gabaergic-mechanisms","display_name":"GABAergic mechanisms","score":0.902999997138977},{"id":"https://openalex.org/keywords/respiratory-plasticity","display_name":"respiratory plasticity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/co2-responsiveness","display_name":"CO2 responsiveness","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ketanserin","display_name":"ketanserin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sudden-infant-death-syndrome","display_name":"sudden infant death syndrome","score":0.7760000228881836},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.48500001430511475},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.414000004529953},{"id":"https://openalex.org/keywords/neonatal-respiratory-development","display_name":"neonatal respiratory development","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.8889589905738831},{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.7460494041442871},{"id":"https://openalex.org/C2777785214","wikidata":"https://www.wikidata.org/wiki/Q415997","display_name":"Ketanserin","level":5,"score":0.7286227345466614},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.573261559009552},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4568714201450348},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.4502508044242859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.450084388256073},{"id":"https://openalex.org/C2781382112","wikidata":"https://www.wikidata.org/wiki/Q7053142","display_name":"Normocapnia","level":4,"score":0.42030981183052063},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3983806371688843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.373857319355011},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3576792776584625},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3395920991897583},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.33853164315223694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29234546422958374},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.2584800720214844},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.23348453640937805},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1379166841506958}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007650","descriptor_name":"Ketanserin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010791","descriptor_name":"Phrenic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010791","descriptor_name":"Phrenic Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.resp.2014.05.005","doi":"https://doi.org/10.1016/j.resp.2014.05.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.resp.2014.05.005","pdf_url":null,"source":{"id":"https://openalex.org/S72042703","display_name":"Respiratory Physiology & Neurobiology","issn_l":"1569-9048","issn":["1569-9048","1878-1519"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Physiology &amp; Neurobiology","raw_type":"journal-article"},{"id":"pmid:24874557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24874557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory physiology & neurobiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4167740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4167740","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Respir Physiol Neurobiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4167740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4167740","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Respir Physiol Neurobiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2710413523","display_name":"Advancing UAF SNRP","funder_award_id":"U54NS041069","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3109211395","display_name":"Characterizing A Raphe Chemosensory Amplifier Network","funder_award_id":"R15HL126105","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3481675194","display_name":"Alaska INBRE-2: Environmental Agents and Disease","funder_award_id":"P20RR016466","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000871176","display_name":"Alaska INBRE 5 One Health","funder_award_id":"P20GM103395","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W183409290","https://openalex.org/W1816316326","https://openalex.org/W1967189169","https://openalex.org/W1968129868","https://openalex.org/W1973962238","https://openalex.org/W1976132208","https://openalex.org/W1990720413","https://openalex.org/W1991947758","https://openalex.org/W1997749666","https://openalex.org/W2007569082","https://openalex.org/W2021541323","https://openalex.org/W2025872245","https://openalex.org/W2035916726","https://openalex.org/W2042977977","https://openalex.org/W2044286637","https://openalex.org/W2045362230","https://openalex.org/W2046264122","https://openalex.org/W2055135519","https://openalex.org/W2059099517","https://openalex.org/W2069048858","https://openalex.org/W2071629944","https://openalex.org/W2079104859","https://openalex.org/W2087096993","https://openalex.org/W2087585605","https://openalex.org/W2092134954","https://openalex.org/W2104671291","https://openalex.org/W2109831177","https://openalex.org/W2116807287","https://openalex.org/W2119243552","https://openalex.org/W2148347681","https://openalex.org/W2157851792","https://openalex.org/W2180868180","https://openalex.org/W2214600193","https://openalex.org/W2258117099","https://openalex.org/W2282950742","https://openalex.org/W2287740762","https://openalex.org/W2328554319","https://openalex.org/W2890873723","https://openalex.org/W4254965144"],"related_works":["https://openalex.org/W3172534605","https://openalex.org/W2186948371","https://openalex.org/W2172246923","https://openalex.org/W1681249975","https://openalex.org/W2592101462","https://openalex.org/W641462054","https://openalex.org/W2111526877","https://openalex.org/W2094270252","https://openalex.org/W2125683116","https://openalex.org/W2186493260"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
