{"id":"https://openalex.org/W2047549866","doi":"https://doi.org/10.1111/j.1751-7133.2008.08283.x","title":"Screening for Asymptomatic Left Ventricular Dysfunction Using B\u2010Type Natriuretic Peptide","display_name":"Screening for Asymptomatic Left Ventricular Dysfunction Using B\u2010Type Natriuretic Peptide","publication_year":2008,"publication_date":"2008-07-01","ids":{"openalex":"https://openalex.org/W2047549866","doi":"https://doi.org/10.1111/j.1751-7133.2008.08283.x","mag":"2047549866","pmid":"https://pubmed.ncbi.nlm.nih.gov/18772638"},"language":"en","primary_location":{"id":"doi:10.1111/j.1751-7133.2008.08283.x","doi":"https://doi.org/10.1111/j.1751-7133.2008.08283.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1751-7133.2008.08283.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1751-7133.2008.08283.x","source":{"id":"https://openalex.org/S26432035","display_name":"Congestive Heart Failure","issn_l":"1527-5299","issn":["1527-5299","1751-7133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congestive Heart Failure","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1751-7133.2008.08283.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109983688","display_name":"Theresa A. McDonagh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["GB","IE","US"],"is_corresponding":true,"raw_author_name":"Theresa A. McDonagh","raw_affiliation_strings":["From Royal Brompton Hospital, London, UK;1\nSt Vincents University Hospital, Dublin, Ireland;2 and the University of California, San Diego, San Diego, CA3","From Royal Brompton Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Royal Brompton Hospital, London, UK;1\nSt Vincents University Hospital, Dublin, Ireland;2 and the University of California, San Diego, San Diego, CA3","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210096640","https://openalex.org/I4210115218"]},{"raw_affiliation_string":"From Royal Brompton Hospital, London, UK","institution_ids":["https://openalex.org/I4210096640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005230910","display_name":"Kenneth McDonald","orcid":"https://orcid.org/0000-0001-8011-3301","observed_orcids":["https://orcid.org/0000-0001-8011-3301"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["GB","IE","US"],"is_corresponding":false,"raw_author_name":"Kenneth McDonald","raw_affiliation_strings":["From Royal Brompton Hospital, London, UK;1\nSt Vincents University Hospital, Dublin, Ireland;2 and the University of California, San Diego, San Diego, CA3","St Vincents University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Royal Brompton Hospital, London, UK;1\nSt Vincents University Hospital, Dublin, Ireland;2 and the University of California, San Diego, San Diego, CA3","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210096640","https://openalex.org/I4210115218"]},{"raw_affiliation_string":"St Vincents University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043012263","display_name":"Alan S. Maisel","orcid":"https://orcid.org/0000-0001-7467-0195","observed_orcids":["https://orcid.org/0000-0001-7467-0195"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["GB","IE","US"],"is_corresponding":false,"raw_author_name":"Alan S. Maisel","raw_affiliation_strings":["From Royal Brompton Hospital, London, UK;1\nSt Vincents University Hospital, Dublin, Ireland;2 and the University of California, San Diego, San Diego, CA3","University of California San Diego, San diego, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Royal Brompton Hospital, London, UK;1\nSt Vincents University Hospital, Dublin, Ireland;2 and the University of California, San Diego, San Diego, CA3","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210096640","https://openalex.org/I4210115218"]},{"raw_affiliation_string":"University of California San Diego, San diego, CA#TAB#","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109983688"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210096640","https://openalex.org/I4210115218"],"apc_list":null,"apc_paid":null,"fwci":1.4131,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.8370564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"4","first_page":"5","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asymptomatic-left-ventricular-dysfunction","display_name":"asymptomatic left ventricular dysfunction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.968999981880188},{"id":"https://openalex.org/keywords/heart-failure-screening","display_name":"heart failure screening","score":0.9100000262260437},{"id":"https://openalex.org/keywords/left-ventricular-systolic-dysfunction","display_name":"left ventricular systolic dysfunction","score":0.9610000252723694},{"id":"https://openalex.org/keywords/heart-failure-prevention","display_name":"heart failure prevention","score":0.5529999732971191},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.7160000205039978},{"id":"https://openalex.org/keywords/natural-history-of-disease","display_name":"natural history of disease","score":0.6320000290870667},{"id":"https://openalex.org/keywords/barriers-to-screening","display_name":"barriers to screening","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9227057695388794},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.8816787004470825},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.822524905204773},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.7230255603790283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7010229229927063},{"id":"https://openalex.org/C2780090379","wikidata":"https://www.wikidata.org/wiki/Q419119","display_name":"Prohormone","level":3,"score":0.6837020516395569},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6727697849273682},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6021844744682312},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5051048398017883},{"id":"https://openalex.org/C2775846464","wikidata":"https://www.wikidata.org/wiki/Q66360952","display_name":"Brain natriuretic peptide","level":3,"score":0.48736387491226196},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06365209817886353},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1751-7133.2008.08283.x","doi":"https://doi.org/10.1111/j.1751-7133.2008.08283.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1751-7133.2008.08283.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1751-7133.2008.08283.x","source":{"id":"https://openalex.org/S26432035","display_name":"Congestive Heart Failure","issn_l":"1527-5299","issn":["1527-5299","1751-7133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congestive Heart Failure","raw_type":"journal-article"},{"id":"doi:10.1111/j.1751-7133.2008.tb00002.x","doi":"https://doi.org/10.1111/j.1751-7133.2008.tb00002.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1751-7133.2008.tb00002.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1751-7133.2008.tb00002.x","source":{"id":"https://openalex.org/S26432035","display_name":"Congestive Heart Failure","issn_l":"1527-5299","issn":["1527-5299","1751-7133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congestive Heart Failure","raw_type":"journal-article"},{"id":"pmid:18772638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18772638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congestive heart failure (Greenwich, Conn.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1751-7133.2008.08283.x","doi":"https://doi.org/10.1111/j.1751-7133.2008.08283.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1751-7133.2008.08283.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1751-7133.2008.08283.x","source":{"id":"https://openalex.org/S26432035","display_name":"Congestive Heart Failure","issn_l":"1527-5299","issn":["1527-5299","1751-7133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congestive Heart Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2047549866.pdf","grobid_xml":"https://content.openalex.org/works/W2047549866.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W14674810","https://openalex.org/W21478844","https://openalex.org/W1570828701","https://openalex.org/W1973027577","https://openalex.org/W1977390656","https://openalex.org/W1988816170","https://openalex.org/W1991442843","https://openalex.org/W2000287422","https://openalex.org/W2005240103","https://openalex.org/W2007946529","https://openalex.org/W2023544056","https://openalex.org/W2030384170","https://openalex.org/W2033989169","https://openalex.org/W2040616060","https://openalex.org/W2046091224","https://openalex.org/W2059920038","https://openalex.org/W2065398947","https://openalex.org/W2086103273","https://openalex.org/W2094410878","https://openalex.org/W2107484365","https://openalex.org/W2112725236","https://openalex.org/W2117118659","https://openalex.org/W2120561016","https://openalex.org/W2121245510","https://openalex.org/W2123671822","https://openalex.org/W2126834790","https://openalex.org/W2127239012","https://openalex.org/W2139552008","https://openalex.org/W2161515908","https://openalex.org/W2176581551","https://openalex.org/W2312388685","https://openalex.org/W2335083084","https://openalex.org/W2469805673","https://openalex.org/W2585382523"],"related_works":["https://openalex.org/W160421518","https://openalex.org/W2077753393","https://openalex.org/W2129927679","https://openalex.org/W2068234041","https://openalex.org/W2007577458","https://openalex.org/W2035525676","https://openalex.org/W2539067367","https://openalex.org/W2049260328","https://openalex.org/W1978136718","https://openalex.org/W1489075861"],"abstract_inverted_index":{"Asymptomatic":[0],"left":[1,84],"ventricular":[2,85],"dysfunction":[3],"(ASLVD),":[4],"a":[5,23,46,101,149],"known":[6],"precursor":[7],"phase":[8],"of":[9,35,103,113,135,148,165],"heart":[10,42,126],"failure,":[11,43],"fulfills":[12],"the":[13,111,125,140,146,155,162,166],"essential":[14],"criteria":[15],"that":[16,66,68,92,110,153,169],"should":[17],"be":[18,95,145],"met":[19],"before":[20],"screening":[21,154,171],"for":[22,157],"disease.":[24],"It":[25],"is":[26,99],"common":[27],"and":[28,33,74,119,121],"associated":[29],"with":[30],"reduced":[31],"longevity":[32],"quality":[34],"life.":[36],"Left":[37],"untreated,":[38],"it":[39],"progresses":[40],"to":[41,124,133,139,177],"which":[44],"incurs":[45],"mortality":[47,120],"greater":[48],"than":[49],"most":[50],"cancers":[51],"as":[52,54],"well":[53,144],"significant":[55],"morbidity":[56,118],"rates.":[57],"In":[58],"addition,":[59],"we":[60],"now":[61],"have":[62,173],"several":[63],"population-based":[64],"studies":[65],"demonstrate":[67],"both":[69,117],"B-type":[70],"natriuretic":[71,78],"peptide":[72,79],"(BNP)":[73],"N-terminal":[75],"prohormone":[76],"brain":[77],"(NTproBNP)":[80],"can":[81,94,115],"accurately":[82],"exclude":[83],"systolic":[86],"dysfunction.":[87],"More":[88],"recent":[89],"work":[90],"shows":[91],"this":[93],"done":[96],"cost-effectively.":[97],"There":[98],"also":[100],"wealth":[102],"evidence":[104],"from":[105],"randomized":[106,150],"controlled":[107],"trials":[108],"indicating":[109],"treatment":[112],"ASLVD":[114,158],"reduce":[116],"slow":[122],"progression":[123],"failure":[127],"state.":[128],"The":[129],"main":[130],"stumbling":[131],"block":[132],"implementation":[134],"screening,":[136],"in":[137],"addition":[138],"perceived":[141],"cost,":[142],"may":[143],"lack":[147],"study":[151],"showing":[152],"population":[156],"really":[159],"does":[160],"alter":[161],"natural":[163],"history":[164],"condition,":[167],"something":[168],"other":[170],"strategies":[172],"so":[174],"far":[175],"failed":[176],"do.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
