{"id":"https://openalex.org/W2047425525","doi":"https://doi.org/10.1002/ijc.2910520123","title":"Jumping translocations originate clonal rearrangements in SV40\u2010transformed human fibroblasts","display_name":"Jumping translocations originate clonal rearrangements in SV40\u2010transformed human fibroblasts","publication_year":1992,"publication_date":"1992-08-19","ids":{"openalex":"https://openalex.org/W2047425525","doi":"https://doi.org/10.1002/ijc.2910520123","mag":"2047425525","pmid":"https://pubmed.ncbi.nlm.nih.gov/1323537"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910520123","doi":"https://doi.org/10.1002/ijc.2910520123","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910520123","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001369482","display_name":"Fran\u00e7oise Hoffschir","orcid":"https://orcid.org/0000-0002-5562-4457","observed_orcids":["https://orcid.org/0000-0002-5562-4457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Hoffschir","raw_affiliation_strings":["DSV-DPTE-LCG, Centre d'Etudes Nucl\u00e9aires de Fontenay-aux-Roses, France","DSV-DPTE-LCG, Centre d'Etudes Nud\u00e9aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSV-DPTE-LCG, Centre d'Etudes Nucl\u00e9aires de Fontenay-aux-Roses, France","institution_ids":[]},{"raw_affiliation_string":"DSV-DPTE-LCG, Centre d'Etudes Nud\u00e9aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112220204","display_name":"Michelle Ricoul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Ricoul","raw_affiliation_strings":["DSV-DPTE-LCG, Centre d'Etudes Nude\u0301aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses","DSV-DPTE-LCG, Centre d'Etudes Nud\u00e9aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSV-DPTE-LCG, Centre d'Etudes Nude\u0301aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses","institution_ids":[]},{"raw_affiliation_string":"DSV-DPTE-LCG, Centre d'Etudes Nud\u00e9aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078337939","display_name":"Nicole Lemieux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Lemieux","raw_affiliation_strings":["URA 620 CNRS, Institut Curie, Section de Biologic, 26 rue d'Ulm, 75231 Paris Cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"URA 620 CNRS, Institut Curie, Section de Biologic, 26 rue d'Ulm, 75231 Paris Cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085085630","display_name":"Simone Estrade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Estrade","raw_affiliation_strings":["UPR 42, Institut de Recherches Scientifiques sur le Cancer, BP N\u00b0 8, 94802 Villejuif Ce\u0301dex","UPR 42, Institut de Recherches Scientifiques sur le Cancer, BP N\u00b0 8, 94802 Villejuif C\u00e9dex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPR 42, Institut de Recherches Scientifiques sur le Cancer, BP N\u00b0 8, 94802 Villejuif Ce\u0301dex","institution_ids":[]},{"raw_affiliation_string":"UPR 42, Institut de Recherches Scientifiques sur le Cancer, BP N\u00b0 8, 94802 Villejuif C\u00e9dex","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110057131","display_name":"Roland Cassingena","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Cassingena","raw_affiliation_strings":["UPR 42, Institut de Recherches Scientifiques sur le Cancer, BP N\u00b0 8, 94802 Villejuif Ce\u0301dex","UPR 42, Institut de Recherches Scientifiques sur le Cancer, BP N\u00b0 8, 94802 Villejuif C\u00e9dex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPR 42, Institut de Recherches Scientifiques sur le Cancer, BP N\u00b0 8, 94802 Villejuif Ce\u0301dex","institution_ids":[]},{"raw_affiliation_string":"UPR 42, Institut de Recherches Scientifiques sur le Cancer, BP N\u00b0 8, 94802 Villejuif C\u00e9dex","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111670605","display_name":"Bernard Dutrillaux","orcid":"https://orcid.org/0000-0002-6814-3310","observed_orcids":["https://orcid.org/0000-0002-6814-3310"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Dutrillaux","raw_affiliation_strings":["DSV-DPTE-LCG, Centre d'Etudes Nude\u0301aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses","URA 620 CNRS, Institut Curie, Section de Biologic, 26 rue d'Ulm, 75231 Paris Cedex 05, France","DSV-DPTE-LCG, Centre d'Etudes Nud\u00e9aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSV-DPTE-LCG, Centre d'Etudes Nude\u0301aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses","institution_ids":[]},{"raw_affiliation_string":"URA 620 CNRS, Institut Curie, Section de Biologic, 26 rue d'Ulm, 75231 Paris Cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]},{"raw_affiliation_string":"DSV-DPTE-LCG, Centre d'Etudes Nud\u00e9aires de Fontenay-aux-Roses, 68 avenue de la Division Leclerc, 92265 Fontenay-aux-Roses","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.1822,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.76559454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"52","issue":"1","first_page":"130","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jumping-translocation","display_name":"jumping translocation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/sv40-transformed-fibroblasts","display_name":"SV40-transformed fibroblasts","score":0.8989999890327454},{"id":"https://openalex.org/keywords/constitutive-heterochromatin","display_name":"constitutive heterochromatin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/telomeric-regions","display_name":"telomeric regions","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chromosome-evolution","display_name":"karyotype evolution","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chromosomal-deletion","display_name":"chromosomal deletion","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7657565474510193},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.7161712646484375},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.6658191680908203},{"id":"https://openalex.org/C86546924","wikidata":"https://www.wikidata.org/wiki/Q3454460","display_name":"Chromosomal rearrangement","level":5,"score":0.5667600631713867},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5473161339759827},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5401214361190796},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.4681549072265625},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.4577142596244812},{"id":"https://openalex.org/C2779897013","wikidata":"https://www.wikidata.org/wiki/Q1151752","display_name":"Jumping","level":2,"score":0.450067400932312},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.43469563126564026},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.31369709968566895},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.30039674043655396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29955363273620605},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910520123","doi":"https://doi.org/10.1002/ijc.2910520123","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910520123","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:1323537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1323537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1567491324","https://openalex.org/W1970162824","https://openalex.org/W1977663501","https://openalex.org/W1981420674","https://openalex.org/W1981876127","https://openalex.org/W1989976890","https://openalex.org/W1992065285","https://openalex.org/W1993410399","https://openalex.org/W2003074592","https://openalex.org/W2005925025","https://openalex.org/W2014862172","https://openalex.org/W2019692499","https://openalex.org/W2025325704","https://openalex.org/W2025544551","https://openalex.org/W2046048384","https://openalex.org/W2051204735","https://openalex.org/W2052488677","https://openalex.org/W2064124111","https://openalex.org/W2070712167","https://openalex.org/W2075300416","https://openalex.org/W2080932299","https://openalex.org/W2083871148","https://openalex.org/W2094485880","https://openalex.org/W2094534092","https://openalex.org/W2101688468","https://openalex.org/W2117646911","https://openalex.org/W2132010690","https://openalex.org/W2142610565","https://openalex.org/W2162505217","https://openalex.org/W2404359139","https://openalex.org/W2886571743"],"related_works":["https://openalex.org/W2014644092","https://openalex.org/W2087857580","https://openalex.org/W2103773918","https://openalex.org/W1981876127","https://openalex.org/W2088150538","https://openalex.org/W2076729367","https://openalex.org/W2404359139","https://openalex.org/W2411186839","https://openalex.org/W2019864024","https://openalex.org/W2074949279"],"abstract_inverted_index":{"A":[0],"comparative":[1],"study":[2],"of":[3,43,59,78,85,88,120,132,137,141],"chromosomal":[4],"rearrangements":[5,51,65,93,147,160],"occurring":[6,100],"in":[7,36,47,151,155,167],"4":[8,115],"independent":[9,116],"clones":[10],"obtained":[11],"from":[12],"SV40-transformed":[13],"cornea":[14],"and":[15,57],"skin":[16],"human":[17,142],"fibroblasts":[18],"was":[19],"performed.":[20],"Rearrangements":[21],"principally":[22,81],"affect":[23],"some":[24,58],"constitutive":[25],"heterochromatin":[26],"and,":[27],"to":[28,63,110,125,162],"a":[29,40,86],"lesser":[30],"degree,":[31],"telomeric":[32],"regions.":[33],"This":[34,71,135],"results":[35],"multiple":[37],"exchanges":[38],"between":[39],"limited":[41],"number":[42,87],"chromosome":[44,89],"structures,":[45],"i.e.,":[46],"jumping":[48,146],"translocations.":[49],"Such":[50],"occur":[52],"even":[53],"at":[54,68,101],"early":[55],"passages":[56],"them":[60],"give":[61],"rise":[62],"clonal":[64,92,107,159],"that":[66,140],"accumulate":[67],"late":[69],"passages.":[70],"process":[72],"is":[73],"responsible":[74],"for":[75,113],"progressive":[76],"modification":[77],"the":[79,114,121,126,130,133],"karyotypes,":[80],"characterized":[82],"by":[83],"deletion":[84],"segments.":[90],"Thus,":[91],"are":[94,148,165],"selected":[95],"among":[96],"many":[97],"others":[98],"not":[99],"random.":[102],"The":[103],"selective":[104],"pressure":[105],"retaining":[106],"rearrangement":[108],"seems":[109],"be":[111],"similar":[112],"clones,":[117],"since":[118,145],"selection":[119],"derivative":[122],"chromosomes":[123],"leads":[124],"same":[127],"imbalances,":[128],"whatever":[129],"origin":[131],"clone.":[134],"sequence":[136],"events":[138],"recalls":[139],"solid":[143],"tumors,":[144],"generally":[149],"observed":[150],"pre-malignant":[152],"conditions":[153],"or":[154],"low-grade":[156],"malignancies,":[157],"whereas":[158],"leading":[161],"typical":[163],"imbalances":[164],"detected":[166],"more":[168],"advanced":[169],"malignant":[170],"tumors.":[171]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}