{"id":"https://openalex.org/W2047388317","doi":"https://doi.org/10.1017/s0031182007002697","title":"Antioxidant gene expression and function inin vitro-developingSchistosoma mansonimother sporocysts: possible role in self-protection","display_name":"Antioxidant gene expression and function inin vitro-developingSchistosoma mansonimother sporocysts: possible role in self-protection","publication_year":2007,"publication_date":"2007-04-20","ids":{"openalex":"https://openalex.org/W2047388317","doi":"https://doi.org/10.1017/s0031182007002697","mag":"2047388317","pmid":"https://pubmed.ncbi.nlm.nih.gov/17445325"},"language":"en","primary_location":{"id":"doi:10.1017/s0031182007002697","doi":"https://doi.org/10.1017/s0031182007002697","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0031182007002697","pdf_url":null,"source":{"id":"https://openalex.org/S161475033","display_name":"Parasitology","issn_l":"0031-1820","issn":["0031-1820","1469-8161"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086099199","display_name":"Jon J. Vermeire","orcid":"https://orcid.org/0000-0001-6073-4071","observed_orcids":["https://orcid.org/0000-0001-6073-4071"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J.\u00a0J. VERMEIRE","raw_affiliation_strings":["Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2115 Observatory Drive, Madison, WI 53706, USA. jon.vermeire@yale.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2115 Observatory Drive, Madison, WI 53706, USA. jon.vermeire@yale.edu","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008692407","display_name":"Timothy P. Yoshino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.\u00a0P. YOSHINO","raw_affiliation_strings":["Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2115 Observatory Drive, Madison, WI 53706, USA","University of Wisconsin, Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2115 Observatory Drive, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin, Madison","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086099199"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":2.6457,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.8933971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"134","issue":"10","first_page":"1369","last_page":"1378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":1.0},{"id":"https://openalex.org/keywords/peroxiredoxin","display_name":"peroxiredoxin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6759999990463257},{"id":"https://openalex.org/keywords/hydrogen-peroxide-scavenging","display_name":"hydrogen peroxide scavenging","score":0.8159999847412109},{"id":"https://openalex.org/keywords/excretory-secretory-proteins","display_name":"excretory-secretory proteins","score":0.9259999990463257},{"id":"https://openalex.org/keywords/miracidia","display_name":"miracidia","score":0.8240000009536743},{"id":"https://openalex.org/keywords/larval-development","display_name":"larval development","score":0.6740000247955322},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6240000128746033},{"id":"https://openalex.org/keywords/biomphalaria-glabrata","display_name":"Biomphalaria glabrata","score":0.8420000076293945},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.8997129201889038},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8884507417678833},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.7203559875488281},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5240095853805542},{"id":"https://openalex.org/C2780416994","wikidata":"https://www.wikidata.org/wiki/Q419462","display_name":"Peroxiredoxin","level":4,"score":0.5098885297775269},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48499318957328796},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4659002721309662},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.46514904499053955},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42054638266563416},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4178900718688965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3727981746196747},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3318285346031189},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31119459867477417},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29842907190322876},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2607514262199402},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.15148839354515076},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.10308444499969482},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017238","descriptor_name":"Genes, Helminth","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017238","descriptor_name":"Genes, Helminth","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017238","descriptor_name":"Genes, Helminth","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1017/s0031182007002697","doi":"https://doi.org/10.1017/s0031182007002697","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0031182007002697","pdf_url":null,"source":{"id":"https://openalex.org/S161475033","display_name":"Parasitology","issn_l":"0031-1820","issn":["0031-1820","1469-8161"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology","raw_type":"journal-article"},{"id":"pmid:17445325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17445325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7764630004","display_name":null,"funder_award_id":"AI015503","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1565225910","https://openalex.org/W1567647424","https://openalex.org/W1971131877","https://openalex.org/W1973807154","https://openalex.org/W1974918402","https://openalex.org/W1980170481","https://openalex.org/W1980757462","https://openalex.org/W1988834288","https://openalex.org/W1989400319","https://openalex.org/W2006169459","https://openalex.org/W2012209371","https://openalex.org/W2014892926","https://openalex.org/W2020000811","https://openalex.org/W2035955143","https://openalex.org/W2040458172","https://openalex.org/W2043251127","https://openalex.org/W2045965339","https://openalex.org/W2054028958","https://openalex.org/W2054396901","https://openalex.org/W2058998227","https://openalex.org/W2064159550","https://openalex.org/W2064920197","https://openalex.org/W2072267457","https://openalex.org/W2078806859","https://openalex.org/W2096977621","https://openalex.org/W2097658635","https://openalex.org/W2105667737","https://openalex.org/W2107277218","https://openalex.org/W2109559369","https://openalex.org/W2115933717","https://openalex.org/W2131041425","https://openalex.org/W2144634347","https://openalex.org/W2165623503","https://openalex.org/W2167055696","https://openalex.org/W2167965719","https://openalex.org/W2170925425","https://openalex.org/W2173778994","https://openalex.org/W2174232493","https://openalex.org/W2180585235","https://openalex.org/W2190667530","https://openalex.org/W2267935709","https://openalex.org/W2313762791","https://openalex.org/W2314225431","https://openalex.org/W2325519527","https://openalex.org/W2329321535","https://openalex.org/W2330149378"],"related_works":["https://openalex.org/W1499027165","https://openalex.org/W1604304380","https://openalex.org/W1973141315","https://openalex.org/W2118595925","https://openalex.org/W4313272373","https://openalex.org/W2001735644","https://openalex.org/W2052303257","https://openalex.org/W2260642016","https://openalex.org/W2116874572","https://openalex.org/W2887393792"],"abstract_inverted_index":{"The":[0],"ability":[1,181],"of":[2,6,23,66,70,100,112,148,153,169,182,199,207,216,238,246],"the":[3,32,37,44,51,62,71,86,117,145,180,214,236,243],"larval":[4,81,166,174,221],"forms":[5],"Schistosoma":[7],"mansoni":[8,104,240],"to":[9,30,42,95,131,184,202],"invade":[10],"and":[11,90,98,106,121,139,150,155,171,209,231],"parasitize":[12],"their":[13,96],"molluscan":[14],"host,":[15],"Biomphalaria":[16],"glabrata,":[17],"is":[18],"determined":[19],"by":[20,35,50,60,176],"a":[21],"multitude":[22],"factors.":[24],"In":[25],"this":[26],"study":[27],"we":[28],"sought":[29],"elucidate":[31],"possible":[33],"mechanisms":[34],"which":[36],"invading":[38],"larvae":[39],"are":[40,123,142,156],"able":[41],"counteract":[43],"potentially":[45],"harmful":[46],"oxidative":[47],"environment":[48],"presented":[49],"host":[52],"upon":[53],"initial":[54],"miracidial":[55],"infection.":[56,247],"This":[57],"was":[58],"attempted":[59],"examining":[61],"gene":[63,211,223],"expression":[64,101,212],"profile":[65],"parasite":[67,159],"antioxidant":[68],"enzymes":[69,119],"linked":[72],"glutathione-(GSH)":[73],"thioredoxin":[74],"(Trx)":[75],"redox":[76],"pathway":[77],"during":[78,125,163,242],"early":[79,126,244],"intramolluscan":[80],"development.":[82],"Three":[83],"such":[84],"enzymes,":[85],"peroxiredoxins":[87],"(Prx1,":[88],"Prx2":[89,140,172,232],"Prx3)":[91],"were":[92],"examined":[93],"as":[94],"activity":[97],"sites":[99],"within":[102,144],"S.":[103,239],"miracidia":[105,149],"in":[107,164,219,235],"vitro-cultured":[108],"mother":[109,127],"sporocysts.":[110],"Results":[111],"these":[113],"studies":[114,134],"demonstrated":[115],"that":[116,137,229],"H(2)O(2)-reducing":[118],"Prx1":[120,138,170,208,230],"2":[122,210],"upregulated":[124],"sporocyst":[128],"development":[129],"compared":[130],"miracidia.":[132],"Immunolocalization":[133],"further":[135],"indicated":[136],"proteins":[141,161,193],"expressed":[143],"apical":[146],"papillae":[147],"tegumental":[151],"syncytium":[152],"sporocysts,":[154],"released":[157],"with":[158,194],"excretory-secretory":[160],"(ESP)":[162],"vitro":[165],"transformation.":[167],"Removal":[168],"from":[173],"ESP":[175,183,191],"immunoabsorption":[177],"significantly":[178],"reduced":[179],"breakdown":[185],"exogenous":[186,203],"H(2)O(2),":[187],"thereby":[188],"directly":[189],"linking":[190],"Prx":[192,222],"H(2)O(2)-scavenging":[195],"activity.":[196],"Moreover,":[197],"exposure":[198],"live":[200],"sporocysts":[201,241],"H(2)O(2)stimulated":[204],"an":[205],"upregulation":[206],"suggesting":[213],"involvement":[215],"H(2)O(2)-responsive":[217],"elements":[218],"regulating":[220],"expression.":[224],"These":[225],"data":[226],"provide":[227],"evidence":[228],"may":[233],"function":[234],"protection":[237],"stages":[245]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}