{"id":"https://openalex.org/W2047331095","doi":"https://doi.org/10.1016/0306-9877(94)90136-8","title":"Calcineurin as a possible new target for treatment of Parkinson's disease","display_name":"Calcineurin as a possible new target for treatment of Parkinson's disease","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W2047331095","doi":"https://doi.org/10.1016/0306-9877(94)90136-8","mag":"2047331095","pmid":"https://pubmed.ncbi.nlm.nih.gov/7815962"},"language":"en","primary_location":{"id":"doi:10.1016/0306-9877(94)90136-8","doi":"https://doi.org/10.1016/0306-9877(94)90136-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-9877(94)90136-8","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055706034","display_name":"Stefaan Wera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"S. Wera","raw_affiliation_strings":["Laboratoire de Biologie Mole\u0107ulaire, Institut de Chime B6, Universit\u00e9 de Li\u00e9ge, Sart-Tilman, Belgium","Laboratoire de Biologie Mole\u0107ulaire, Institut de Chime B6, Universit\u00e9 de Li\u00e9ge, B-4000 Sart-Tilman, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Mole\u0107ulaire, Institut de Chime B6, Universit\u00e9 de Li\u00e9ge, Sart-Tilman, Belgium","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"Laboratoire de Biologie Mole\u0107ulaire, Institut de Chime B6, Universit\u00e9 de Li\u00e9ge, B-4000 Sart-Tilman, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"J. Neyts","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089010495"],"corresponding_institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"],"apc_list":{"value":2820,"currency":"USD","value_usd":2820},"apc_paid":null,"fwci":0.6027,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.66976136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"43","issue":"3","first_page":"132","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.9750000238418579},{"id":"https://openalex.org/keywords/immunophilins","display_name":"immunophilins","score":0.8180000185966492},{"id":"https://openalex.org/keywords/darpp-32","display_name":"DARPP-32","score":0.9150000214576721},{"id":"https://openalex.org/keywords/protein-phosphatase-1","display_name":"protein phosphatase 1","score":0.953000009059906},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.8619999885559082},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.8334290981292725},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7416637539863586},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7277261018753052},{"id":"https://openalex.org/C2777061661","wikidata":"https://www.wikidata.org/wiki/Q423934","display_name":"Phosphoprotein","level":3,"score":0.7077111601829529},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6491631865501404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5219570994377136},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.4592338502407074},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44745534658432007},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.43108922243118286},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.4306888282299042},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42706766724586487},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.4267776608467102},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.41013437509536743},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4002499580383301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34426259994506836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3292127251625061},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27428966760635376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26851600408554077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20918890833854675},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.15362566709518433},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.09864574670791626}],"mesh":[{"descriptor_ui":"D002148","descriptor_name":"Calmodulin-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0306-9877(94)90136-8","doi":"https://doi.org/10.1016/0306-9877(94)90136-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-9877(94)90136-8","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},{"id":"pmid:7815962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7815962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical hypotheses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1539309411","https://openalex.org/W1643311486","https://openalex.org/W1967603109","https://openalex.org/W1967637078","https://openalex.org/W1984754431","https://openalex.org/W1986782732","https://openalex.org/W2015500392","https://openalex.org/W2015567337","https://openalex.org/W2015932636","https://openalex.org/W2049668076","https://openalex.org/W2081532549","https://openalex.org/W2091538386","https://openalex.org/W2415545741","https://openalex.org/W2464541045","https://openalex.org/W4253757328","https://openalex.org/W6719353790"],"related_works":["https://openalex.org/W2536755424","https://openalex.org/W2327989865","https://openalex.org/W2039641335","https://openalex.org/W1997063937","https://openalex.org/W1967603109","https://openalex.org/W1988581414","https://openalex.org/W1480470394","https://openalex.org/W6902225799","https://openalex.org/W7038640099","https://openalex.org/W1999903260"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
