{"id":"https://openalex.org/W2047318784","doi":"https://doi.org/10.1056/nejmoa032295","title":"A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer","display_name":"A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer","publication_year":2004,"publication_date":"2004-03-17","ids":{"openalex":"https://openalex.org/W2047318784","doi":"https://doi.org/10.1056/nejmoa032295","mag":"2047318784","pmid":"https://pubmed.ncbi.nlm.nih.gov/15028824"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa032295","doi":"https://doi.org/10.1056/nejmoa032295","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa032295","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34187361","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052825850","display_name":"John P. Neoptolemos","orcid":"https://orcid.org/0000-0002-6201-7399","observed_orcids":["https://orcid.org/0000-0002-6201-7399"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John P. Neoptolemos","raw_affiliation_strings":["Department of Surgery, Liverpool University, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Liverpool University, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023057149","display_name":"Deborah D. Stocken","orcid":"https://orcid.org/0000-0001-8031-1738","observed_orcids":["https://orcid.org/0000-0001-8031-1738"]},"institutions":[{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deborah D. Stocken","raw_affiliation_strings":["Cancer Research U.K. Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research U.K. Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I4210135017","https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110132975","display_name":"Helmut Friess","orcid":"https://orcid.org/0000-0001-6029-5857","observed_orcids":["https://orcid.org/0000-0001-6029-5857"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helmut Friess","raw_affiliation_strings":["University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074748035","display_name":"Claudio Bassi","orcid":"https://orcid.org/0000-0002-5416-329X","observed_orcids":["https://orcid.org/0000-0002-5416-329X"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Bassi","raw_affiliation_strings":["Surgical Department, University of Verona, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Department, University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028914408","display_name":"Janet Dunn","orcid":"https://orcid.org/0000-0001-7313-4446","observed_orcids":["https://orcid.org/0000-0001-7313-4446"]},"institutions":[{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Janet A. Dunn","raw_affiliation_strings":["Cancer Research U.K. Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research U.K. Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I4210135017","https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063923011","display_name":"Helen Hickey","orcid":"https://orcid.org/0000-0003-0467-0362","observed_orcids":["https://orcid.org/0000-0003-0467-0362"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen Hickey","raw_affiliation_strings":["Department of Surgery, Liverpool University, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Liverpool University, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110885650","display_name":"Hans G. Beger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans Beger","raw_affiliation_strings":["University Hospital of Surgery, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Surgery, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016687244","display_name":"Laureano Fern\u00e1ndez\u2010Cruz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laureano Fernandez-Cruz","raw_affiliation_strings":["Barcelona University Hospital, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barcelona University Hospital, Barcelona, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108218933","display_name":"Christos Dervenis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154864","display_name":"Agia Olga Hospital","ror":"https://ror.org/050zvc738","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210154864"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos Dervenis","raw_affiliation_strings":["Department of Surgery, Agia Olga Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Agia Olga Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210154864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024153667","display_name":"FRAN\u00c7OIS LACAINE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Lacaine","raw_affiliation_strings":["Service de Chirurgie Digestive et G\u00e9n\u00e9rale, H\u00f4pital Tenon, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Chirurgie Digestive et G\u00e9n\u00e9rale, H\u00f4pital Tenon, Paris","institution_ids":["https://openalex.org/I4210166768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057380925","display_name":"Massimo Falconi","orcid":"https://orcid.org/0000-0001-9654-7243","observed_orcids":["https://orcid.org/0000-0001-9654-7243"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Falconi","raw_affiliation_strings":["Surgical Department, University of Verona, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Department, University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105839727","display_name":"Paolo Pederzoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Pederzoli","raw_affiliation_strings":["Surgical Department, University of Verona, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Department, University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104350200","display_name":"\u00c1kos Pap","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akos Pap","raw_affiliation_strings":["Department of Gastroenterology, Mav Hospital, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Mav Hospital, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060939857","display_name":"David A. Spooner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Spooner","raw_affiliation_strings":["Department of Radiotherapy, Queen Elizabeth Hospital, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Queen Elizabeth Hospital, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038254746","display_name":"David James Kerr","orcid":"https://orcid.org/0000-0001-7811-6722","observed_orcids":["https://orcid.org/0000-0001-7811-6722"]},"institutions":[{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Kerr","raw_affiliation_strings":["Cancer Research U.K. Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research U.K. Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I4210135017","https://openalex.org/I79619799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036032282","display_name":"Markus Wolfgang B\u00fcchler","orcid":"https://orcid.org/0000-0002-3666-5675","observed_orcids":["https://orcid.org/0000-0002-3666-5675"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus W. B\u00fcchler","raw_affiliation_strings":["University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":52.4408,"has_fulltext":false,"cited_by_count":2716,"citation_normalized_percentile":{"value":0.99953251,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"350","issue":"12","first_page":"1200","last_page":"1210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/adjuvant-chemoradiotherapy","display_name":"adjuvant chemoradiotherapy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pancreatectomy","display_name":"pancreatic resection","score":0.7149999737739563},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.906000018119812},{"id":"https://openalex.org/keywords/5-year-survival","display_name":"five-year survival","score":0.8579999804496765},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9317806363105774},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.7363715171813965},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6824073791503906},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6459323167800903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5868817567825317},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.5420267581939697},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.5279257297515869},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.4761892855167389},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.454953134059906},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.45481550693511963},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4398404061794281},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.38095369935035706},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38036978244781494}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1056/nejmoa032295","doi":"https://doi.org/10.1056/nejmoa032295","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa032295","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:15028824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15028824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/7b231263-9beb-4704-9188-bf03d8d39516","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/7b231263-9beb-4704-9188-bf03d8d39516","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neoptolemos, JP, Stocken, D, Friess, H, Bassi, C, Dunn, J, Hickey, H, Beger, H, Fernandez-Cruz, L, Dervenis, C, Lacaine, F, Falconi, M, Pederzoli, P, Pap, A, Spooner, D, Kerr, DJ & Buchler, MW 2004, 'A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer', New England Journal of Medicine, vol. 350, pp. 1200-1210. https://doi.org/10.1056/NEJMoa032295","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/7b231263-9beb-4704-9188-bf03d8d39516","doi":null,"is_oa":false,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=12144287320&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neoptolemos, JP, Stocken, D, Friess, H, Bassi, C, Dunn, J, Hickey, H, Beger, H, Fernandez-Cruz, L, Dervenis, C, Lacaine, F, Falconi, M, Pederzoli, P, Pap, A, Spooner, D, Kerr, DJ & Buchler, MW 2004, 'A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer', New England Journal of Medicine, vol. 350, pp. 1200-1210. https://doi.org/10.1056/NEJMoa032295","raw_type":"article"},{"id":"doi:10.25405/ncl.34187361","doi":"https://doi.org/10.25405/ncl.34187361","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34187361","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34187361.v1","doi":"https://doi.org/10.25405/ncl.34187361.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34187361.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34187361","doi":"https://doi.org/10.25405/ncl.34187361","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34187361","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W176315691","https://openalex.org/W1580788756","https://openalex.org/W1969875009","https://openalex.org/W1970879086","https://openalex.org/W1974215313","https://openalex.org/W1974219858","https://openalex.org/W1979300931","https://openalex.org/W1982180093","https://openalex.org/W2000424590","https://openalex.org/W2005660567","https://openalex.org/W2014718897","https://openalex.org/W2015083350","https://openalex.org/W2027451548","https://openalex.org/W2027806388","https://openalex.org/W2029226212","https://openalex.org/W2038252730","https://openalex.org/W2043512623","https://openalex.org/W2066097107","https://openalex.org/W2071655635","https://openalex.org/W2073810602","https://openalex.org/W2079934168","https://openalex.org/W2080985235","https://openalex.org/W2094033696","https://openalex.org/W2109694492","https://openalex.org/W2111736523","https://openalex.org/W2115812130","https://openalex.org/W2117954462","https://openalex.org/W2128203605","https://openalex.org/W2128562119","https://openalex.org/W2146621833","https://openalex.org/W2150881991","https://openalex.org/W2167571044","https://openalex.org/W2304239525","https://openalex.org/W3041047318","https://openalex.org/W3147894994","https://openalex.org/W4241578751"],"related_works":["https://openalex.org/W2487490720","https://openalex.org/W2793077515","https://openalex.org/W4292573045","https://openalex.org/W2126365059","https://openalex.org/W4386009577","https://openalex.org/W2981615369","https://openalex.org/W3130621552","https://openalex.org/W2606644627","https://openalex.org/W3048651736","https://openalex.org/W3183420953"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,85,110,135,158],"effect":[2,189],"of":[3,18,102,160],"adjuvant":[4,184],"treatment":[5,54],"on":[6,89,190],"survival":[7,113,137,175],"in":[8,177],"pancreatic":[9,50,181],"cancer":[10],"is":[11],"unclear.":[12],"We":[13],"report":[14],"the":[15,19,30,93],"final":[16],"results":[17],"European":[20],"Study":[21],"Group":[22],"for":[23,165],"Pancreatic":[24],"Cancer":[25],"1":[26],"Trial":[27],"and":[28,77,79,98,124,147],"update":[29],"interim":[31],"results.":[32],"METHODS:":[33],"In":[34],"a":[35,39,61,99,173,187],"multicenter":[36],"trial":[37],"using":[38],"two-by-two":[40],"factorial":[41],"design,":[42],"we":[43],"randomly":[44],"assigned":[45,120],"73":[46],"patients":[47,67,73,81,95,119,128,143,151,178],"with":[48,55,179],"resected":[49,180],"ductal":[51],"adenocarcinoma":[52],"to":[53,68,74,82,108,121],"chemoradiotherapy":[56,76,123,133,185],"alone":[57,70],"(20":[58],"Gy":[59],"over":[60],"two-week":[62],"period":[63],"plus":[64],"fluorouracil),":[65],"75":[66],"chemotherapy":[69,146,156,161,171],"(fluorouracil),":[71],"72":[72],"both":[75],"chemotherapy,":[78],"69":[80],"observation.":[83],"RESULTS:":[84],"analysis":[86],"was":[87,115,139],"based":[88],"237":[90],"deaths":[91],"among":[92,118,127,142,150],"289":[94],"(82":[96],"percent)":[97],"median":[100],"follow-up":[101],"47":[103],"months":[104],"(interquartile":[105],"range,":[106],"33":[107],"62).":[109],"estimated":[111],"five-year":[112,136],"rate":[114,138],"10":[116],"percent":[117,126,141,149],"receive":[122,132,155],"20":[125],"who":[129,144,152],"did":[130,153],"not":[131,154],"(P=0.05).":[134],"21":[140],"received":[145],"8":[148],"(P=0.009).":[157],"benefit":[159,176],"persisted":[162],"after":[163],"adjustment":[164],"major":[166],"prognostic":[167],"factors.":[168],"CONCLUSIONS:":[169],"Adjuvant":[170],"has":[172,186],"significant":[174],"cancer,":[182],"whereas":[183],"deleterious":[188],"survival.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":44},{"year":2025,"cited_by_count":83},{"year":2024,"cited_by_count":88},{"year":2023,"cited_by_count":96},{"year":2022,"cited_by_count":123},{"year":2021,"cited_by_count":140},{"year":2020,"cited_by_count":141},{"year":2019,"cited_by_count":138},{"year":2018,"cited_by_count":134},{"year":2017,"cited_by_count":162},{"year":2016,"cited_by_count":158},{"year":2015,"cited_by_count":147},{"year":2014,"cited_by_count":118},{"year":2013,"cited_by_count":128},{"year":2012,"cited_by_count":130}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}