{"id":"https://openalex.org/W2047310345","doi":"https://doi.org/10.1038/ki.2014.236","title":"The potential for renoprotection with incretin-based drugs","display_name":"The potential for renoprotection with incretin-based drugs","publication_year":2014,"publication_date":"2014-07-09","ids":{"openalex":"https://openalex.org/W2047310345","doi":"https://doi.org/10.1038/ki.2014.236","mag":"2047310345","pmid":"https://pubmed.ncbi.nlm.nih.gov/25007170"},"language":"en","primary_location":{"id":"doi:10.1038/ki.2014.236","doi":"https://doi.org/10.1038/ki.2014.236","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.2014.236","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1038/ki.2014.236","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007057754","display_name":"Tetsuhiro Tanaka","orcid":"https://orcid.org/0000-0002-2238-4215","observed_orcids":["https://orcid.org/0000-0002-2238-4215"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsuhiro Tanaka","raw_affiliation_strings":["Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043850979","display_name":"Yoshiki Higashijima","orcid":"https://orcid.org/0000-0002-4489-606X","observed_orcids":["https://orcid.org/0000-0002-4489-606X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiki Higashijima","raw_affiliation_strings":["Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059943171","display_name":"Takehiko Wada","orcid":"https://orcid.org/0000-0002-1231-2656","observed_orcids":["https://orcid.org/0000-0002-1231-2656","https://orcid.org/0000-0002-9321-4918"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehiko Wada","raw_affiliation_strings":["Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036113498","display_name":"Masaomi Nangaku","orcid":"https://orcid.org/0000-0001-7401-2934","observed_orcids":["https://orcid.org/0000-0001-7401-2934"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaomi Nangaku","raw_affiliation_strings":["Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007057754"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.087,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.88352273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"86","issue":"4","first_page":"701","last_page":"711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.21279999613761902,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.9319999814033508},{"id":"https://openalex.org/keywords/incretin-based-therapy","display_name":"incretin-based therapy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8009999990463257},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.6940000057220459},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9800000190734863},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.8090000152587891},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7680000066757202},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9259999990463257},{"id":"https://openalex.org/keywords/stromal-derived-factor-1alpha","display_name":"stromal-derived factor-1\u03b1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C2778881409","wikidata":"https://www.wikidata.org/wiki/Q1420402","display_name":"Incretin","level":4,"score":0.6030409336090088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5771597623825073},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5440837144851685},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22489336133003235},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.21986457705497742},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.11795151233673096}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/ki.2014.236","doi":"https://doi.org/10.1038/ki.2014.236","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.2014.236","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},{"id":"pmid:25007170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25007170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international","raw_type":"Journal Article"},{"id":"mag:2532223869","doi":null,"is_oa":false,"landing_page_url":"https://www.kidney-international.org/article/S0085-2538(15)30393-8/pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1038/ki.2014.236","doi":"https://doi.org/10.1038/ki.2014.236","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.2014.236","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3555510288","display_name":"Regulation of hypoxia inducible genes in chronic kidney disease","funder_award_id":"26461215","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W54677887","https://openalex.org/W840007291","https://openalex.org/W1602938658","https://openalex.org/W1783549145","https://openalex.org/W1968889601","https://openalex.org/W1969932276","https://openalex.org/W1970306100","https://openalex.org/W1971721011","https://openalex.org/W1973901069","https://openalex.org/W1975385722","https://openalex.org/W1977179808","https://openalex.org/W1979842928","https://openalex.org/W1980130009","https://openalex.org/W1981183973","https://openalex.org/W1983883248","https://openalex.org/W1988049600","https://openalex.org/W1992116679","https://openalex.org/W1993252135","https://openalex.org/W1994593037","https://openalex.org/W1995122286","https://openalex.org/W1995773576","https://openalex.org/W1999843320","https://openalex.org/W2000258452","https://openalex.org/W2000823223","https://openalex.org/W2000976083","https://openalex.org/W2001207089","https://openalex.org/W2011601530","https://openalex.org/W2013102869","https://openalex.org/W2014829685","https://openalex.org/W2015169646","https://openalex.org/W2018576497","https://openalex.org/W2028849170","https://openalex.org/W2031848004","https://openalex.org/W2033746319","https://openalex.org/W2035040393","https://openalex.org/W2035547604","https://openalex.org/W2048505222","https://openalex.org/W2051833527","https://openalex.org/W2052301782","https://openalex.org/W2053433479","https://openalex.org/W2054484970","https://openalex.org/W2055665437","https://openalex.org/W2055678371","https://openalex.org/W2056693113","https://openalex.org/W2058574639","https://openalex.org/W2059287255","https://openalex.org/W2059555444","https://openalex.org/W2059903872","https://openalex.org/W2064130493","https://openalex.org/W2064277057","https://openalex.org/W2065399019","https://openalex.org/W2066235786","https://openalex.org/W2067782368","https://openalex.org/W2068776590","https://openalex.org/W2070768644","https://openalex.org/W2076600348","https://openalex.org/W2081559121","https://openalex.org/W2082503109","https://openalex.org/W2090360729","https://openalex.org/W2092833954","https://openalex.org/W2093552577","https://openalex.org/W2098509177","https://openalex.org/W2101097479","https://openalex.org/W2102186999","https://openalex.org/W2102392334","https://openalex.org/W2103836608","https://openalex.org/W2107943486","https://openalex.org/W2107949845","https://openalex.org/W2107988751","https://openalex.org/W2108822380","https://openalex.org/W2109795536","https://openalex.org/W2109889741","https://openalex.org/W2111538581","https://openalex.org/W2112948259","https://openalex.org/W2113985146","https://openalex.org/W2116831537","https://openalex.org/W2117096134","https://openalex.org/W2118090274","https://openalex.org/W2120431951","https://openalex.org/W2120622647","https://openalex.org/W2120650956","https://openalex.org/W2125617388","https://openalex.org/W2126870113","https://openalex.org/W2127854619","https://openalex.org/W2129730863","https://openalex.org/W2140980725","https://openalex.org/W2142400535","https://openalex.org/W2147855451","https://openalex.org/W2148495354","https://openalex.org/W2150379125","https://openalex.org/W2152096085","https://openalex.org/W2152731692","https://openalex.org/W2152835319","https://openalex.org/W2153625048","https://openalex.org/W2156232364","https://openalex.org/W2159873320","https://openalex.org/W2163837966","https://openalex.org/W2164875000","https://openalex.org/W2166051277","https://openalex.org/W2167763876","https://openalex.org/W2170271198","https://openalex.org/W2171483278","https://openalex.org/W2337454357"],"related_works":["https://openalex.org/W2898103317","https://openalex.org/W3102119644","https://openalex.org/W2327854343","https://openalex.org/W1969068062","https://openalex.org/W2369710042","https://openalex.org/W2072898110","https://openalex.org/W3211812218","https://openalex.org/W4380928260","https://openalex.org/W2986393362","https://openalex.org/W1992054673"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}