{"id":"https://openalex.org/W2047243728","doi":"https://doi.org/10.1017/s0033291700045815","title":"Sedative effects on physiological and psychological measures in anxious patients","display_name":"Sedative effects on physiological and psychological measures in anxious patients","publication_year":1974,"publication_date":"1974-11-01","ids":{"openalex":"https://openalex.org/W2047243728","doi":"https://doi.org/10.1017/s0033291700045815","mag":"2047243728","pmid":"https://pubmed.ncbi.nlm.nih.gov/4156410"},"language":"en","primary_location":{"id":"doi:10.1017/s0033291700045815","doi":"https://doi.org/10.1017/s0033291700045815","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0033291700045815","pdf_url":null,"source":{"id":"https://openalex.org/S71144982","display_name":"Psychological Medicine","issn_l":"0033-2917","issn":["0033-2917","1469-8978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychological Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110597615","display_name":"Alyson J. Bond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alyson J. Bond","raw_affiliation_strings":["Institute of Psychiatry, De Crespigny Park, Denmark Hill, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry, De Crespigny Park, Denmark Hill, London","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Colin James","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Colin James","raw_affiliation_strings":["Institute of Psychiatry, De Crespigny Park, Denmark Hill, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry, De Crespigny Park, Denmark Hill, London","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108285762","display_name":"MALCOLM H. LADER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malcolm H. Lader","raw_affiliation_strings":["Institute of Psychiatry, De Crespigny Park, Denmark Hill, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry, De Crespigny Park, Denmark Hill, London","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":4.8685,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.94687842,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"4","first_page":"374","last_page":"380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-anxiety","display_name":"chronic anxiety","score":0.7160000205039978},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.921999990940094},{"id":"https://openalex.org/keywords/amylobarbitone","display_name":"amylobarbitone","score":0.7509999871253967},{"id":"https://openalex.org/keywords/chlordiazepoxide","display_name":"chlordiazepoxide","score":0.9769999980926514},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":1.0},{"id":"https://openalex.org/keywords/medazepam","display_name":"medazepam","score":0.984000027179718},{"id":"https://openalex.org/keywords/sedative-effects","display_name":"sedative effects","score":0.8479999899864197},{"id":"https://openalex.org/keywords/eeg-slow-wave-activity","display_name":"EEG slow-wave activity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/auditory-evoked-potentials","display_name":"auditory evoked potentials","score":0.8669999837875366},{"id":"https://openalex.org/keywords/skin-conductance","display_name":"skin conductance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/motor-speed","display_name":"motor speed","score":0.7680000066757202},{"id":"https://openalex.org/keywords/digit-symbol-substitution-test","display_name":"Digit Symbol Substitution Test","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hamilton-depression-rating-scale","display_name":"Hamilton Depression Rating Scale","score":0.6200000047683716},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C2778325228","wikidata":"https://www.wikidata.org/wiki/Q178566","display_name":"Chlordiazepoxide","level":3,"score":0.662727415561676},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6156907081604004},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5554496049880981},{"id":"https://openalex.org/C111902132","wikidata":"https://www.wikidata.org/wiki/Q1326834","display_name":"Skin conductance","level":2,"score":0.5272247791290283},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.5261002779006958},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.5209366083145142},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.4944596290588379},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.41250404715538025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24790599942207336},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.24515897035598755},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000654","descriptor_name":"Amobarbital","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001307","descriptor_name":"Auditory Perception","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002707","descriptor_name":"Chlordiazepoxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005071","descriptor_name":"Evoked Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005712","descriptor_name":"Galvanic Skin Response","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008472","descriptor_name":"Medazepam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009048","descriptor_name":"Motor Skills","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012025","descriptor_name":"Reflex, Pupillary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1017/s0033291700045815","doi":"https://doi.org/10.1017/s0033291700045815","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0033291700045815","pdf_url":null,"source":{"id":"https://openalex.org/S71144982","display_name":"Psychological Medicine","issn_l":"0033-2917","issn":["0033-2917","1469-8978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychological Medicine","raw_type":"journal-article"},{"id":"pmid:4156410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4156410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychological medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1520822820","https://openalex.org/W1966691663","https://openalex.org/W1983084712","https://openalex.org/W1989314580","https://openalex.org/W2058238381","https://openalex.org/W2062398025","https://openalex.org/W2069644949","https://openalex.org/W2069878949","https://openalex.org/W2130169935","https://openalex.org/W2160070901","https://openalex.org/W2332592138","https://openalex.org/W2412476334","https://openalex.org/W4365806307"],"related_works":["https://openalex.org/W2013670571","https://openalex.org/W2062398025","https://openalex.org/W2130169935","https://openalex.org/W2085134371","https://openalex.org/W2134571792","https://openalex.org/W2560797394","https://openalex.org/W2047925202","https://openalex.org/W2470489909","https://openalex.org/W2100588177","https://openalex.org/W1975102912"],"abstract_inverted_index":{"SYSNOPSIS":[0],"Twenty":[1],"outpatients":[2],"with":[3,31,79,163],"chronic":[4],"anxiety":[5],"states":[6],"were":[7,91,141],"tested":[8],"on":[9,120,132],"a":[10,32,51],"large":[11],"battery":[12],"of":[13,50,103],"physiological":[14,127,152,158],"and":[15,23,29,75,81,86,98,116,136,147,150],"psychological":[16],"tests":[17,56],"after":[18],"amylobarbitone":[19],"sodium,":[20],"chlordiazepoxide,":[21],"diazepam,":[22],"medazepam":[24],"given":[25],"in":[26,112],"flexible":[27],"dosage":[28],"compared":[30],"placebo.":[33],"Each":[34],"patient":[35,82,148],"received":[36],"all":[37],"five":[38],"treatments":[39],"for":[40],"two":[41],"to":[42],"four":[43],"weeks":[44],"under":[45],"double-blind":[46],"conditions,":[47],"as":[48],"part":[49],"fully":[52],"balanced":[53],"design.":[54],"The":[55,93],"included":[57],"the":[58,60,66,71,88,104,107,113,121,133,144,151],"electroencephalogram,":[59],"auditory":[61],"evoked":[62,108],"response,":[63,109],"skin":[64,114],"conductance,":[65,115],"Digit":[67],"Symbol":[68],"Substitution":[69],"Test,":[70],"Gibson":[72,122,134],"Spiral":[73],"Maze,":[74],"arithmetic":[76,137],"tests,":[77],"together":[78],"psychiatrist":[80],"ratings.":[83],"Correlations":[84],"within":[85],"between":[87,143],"different":[89],"measures":[90],"computed.":[92],"benzodiazepines":[94],"depressed":[95],"slow":[96],"wave":[97,101],"increased":[99],"fast":[100],"activity":[102],"EEG,":[105],"diminished":[106],"reduced":[110],"fluctuations":[111],"decreased":[117],"motor":[118],"speed":[119],"Maze.":[123],"Amylobarbitone":[124],"had":[125],"less":[126],"effect":[128],"but":[129],"impaired":[130],"performance":[131],"Maze":[135],"tests.":[138],"Significant":[139],"correlations":[140,162],"found":[142],"mean":[145],"Hamilton":[146],"ratings":[149],"measures.":[153],"It":[154],"is":[155],"concluded":[156],"that":[157],"changes":[159],"show":[160],"useful":[161],"clinical":[164],"effects.":[165]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}