{"id":"https://openalex.org/W2046961608","doi":"https://doi.org/10.1093/neuonc/nou273.1","title":"RM-01 * RADIATION INDUCED PRMT5 EXPRESSION IS REGULATED BY miRNA-96 IN GLIOBLASTOMA","display_name":"RM-01 * RADIATION INDUCED PRMT5 EXPRESSION IS REGULATED BY miRNA-96 IN GLIOBLASTOMA","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2046961608","doi":"https://doi.org/10.1093/neuonc/nou273.1","mag":"2046961608"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/nou273.1","doi":"https://doi.org/10.1093/neuonc/nou273.1","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nou273.1","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4218557","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058531555","display_name":"Yeshavanth Banasavadi\u2010Siddegowda","orcid":"https://orcid.org/0000-0002-4730-6918","observed_orcids":["https://orcid.org/0000-0002-4730-6918"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. K. Banasavadi-Siddegowda","raw_affiliation_strings":["Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015589637","display_name":"Jaime Imitola","orcid":"https://orcid.org/0000-0003-2008-3133","observed_orcids":["https://orcid.org/0000-0003-2008-3133","https://orcid.org/0009-0008-7400-9661"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Imitola","raw_affiliation_strings":["Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012846289","display_name":"Robert A. Baiocchi","orcid":"https://orcid.org/0000-0002-1619-4853","observed_orcids":["https://orcid.org/0000-0002-1619-4853","https://orcid.org/0000-0002-6518-8169"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Baiocchi","raw_affiliation_strings":["Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041131555","display_name":"Balveen Kaur","orcid":"https://orcid.org/0000-0001-7738-0804","observed_orcids":["https://orcid.org/0000-0001-7738-0804"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Kaur","raw_affiliation_strings":["Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"suppl 5","first_page":"v186","last_page":"v186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.2078000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/prmt5","display_name":"PRMT5","score":0.9940000176429749},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.6690000295639038},{"id":"https://openalex.org/keywords/neurospheres","display_name":"neurospheres","score":0.7670000195503235},{"id":"https://openalex.org/keywords/radiation-induced-gene-expression","display_name":"radiation-induced gene expression","score":0.7599999904632568},{"id":"https://openalex.org/keywords/protein-arginine-methyltransferase","display_name":"protein arginine methyltransferase","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C111819275","wikidata":"https://www.wikidata.org/wiki/Q18035368","display_name":"Protein arginine methyltransferase 5","level":5,"score":0.9631727933883667},{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.870476245880127},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.5818853378295898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5527582764625549},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5378057360649109},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5301281809806824},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5019505023956299},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4213816225528717},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3848660886287689},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.362712562084198},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2547715902328491},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21570435166358948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18617364764213562},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.13015136122703552},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/nou273.1","doi":"https://doi.org/10.1093/neuonc/nou273.1","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nou273.1","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4218557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4218557","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4218557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4218557","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362541714","https://openalex.org/W2109483913","https://openalex.org/W2970666008","https://openalex.org/W1496681723","https://openalex.org/W4308977044","https://openalex.org/W4282963367","https://openalex.org/W7038724469","https://openalex.org/W2899699334","https://openalex.org/W2474486663","https://openalex.org/W2767761077"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glioblastoma":[1],"(GB)":[2],"represent":[3],"the":[4,47,51,95,209,243],"most":[5],"common":[6],"and":[7,14,32,43,69,126,133,149,175,231],"aggressive":[8],"histological":[9],"subtype":[10],"among":[11],"malignant":[12],"gliomas":[13],"are":[15,93,240],"associated":[16],"with":[17,50,113,117,144,192,250],"poor":[18],"outcomes.":[19],"It":[20],"is":[21,46,72,153,182,219],"composed":[22],"of":[23,26,41,97,163,184,205,211,223,245,266,271,278],"multiple":[24,30],"types":[25],"tumor":[27,36],"cells":[28,123],"displaying":[29],"genetic":[31],"epigenetic":[33],"defects":[34],"affecting":[35],"suppressor":[37],"gene":[38],"expression,":[39,165],"regulation":[40,222],"growth":[42],"apoptosis.":[44],"Recurrence":[45],"major":[48],"concern":[49],"current":[52],"standard":[53],"therapy.":[54],"Protein":[55],"arginine":[56],"methyltransferase":[57],"enzyme":[58],"5":[59],"(PRMT5),":[60],"that":[61,79,141,150,217,261,275],"regulates":[62,208],"many":[63],"cellular":[64],"processes":[65],"through":[66],"its":[67,185,190],"methylation-dependent":[68],"independent":[70,183],"activity":[71],"overexpressed":[73],"in":[74,84,99,102,146,236,248,252,285],"this":[75,151],"disease.":[76],"We":[77,139,239],"hypothesize":[78],"PRMT5":[80,98,142,156,169,212,218,246,279],"contributes":[81],"to":[82,160,233],"radioresistance":[83,101,284],"GB.":[85,103,286],"Using":[86],"patient":[87],"derived":[88],"GB":[89,105,147],"neurosphere":[90],"models":[91],"we":[92,215,259],"probing":[94],"role":[96],"inducing":[100],"METHODS:":[104],"neurospheres":[106,148],"dispersed":[107],"into":[108],"single":[109],"cell,":[110],"were":[111,124],"treated":[112],"radiation":[114,166,195,230,237,251,262],"or":[115],"transfected":[116],"specified":[118],"siRNAs.":[119],"At":[120],"appropriate":[121],"time,":[122],"collected":[125],"probed":[127],"for":[128,155,221,282],"mRNA":[129,170],"expression":[130,177,210,270,277],"by":[131,136,172,178,189],"qPCR":[132],"protein":[134,176],"level":[135,171,199],"immunblotting.":[137],"RESULTS:":[138],"found":[140,216],"associates":[143],"Hsp90":[145],"binding":[152],"essential":[154],"stability.":[157],"In":[158],"addition":[159],"higher":[161],"levels":[162],"baseline":[164],"treatment":[167,196,263],"increases":[168],"2":[173],"fold":[174],"60%.":[179],"This":[180,273],"increase":[181],"post-translational":[186],"stability":[187],"conferred":[188],"association":[191],"Hsp90.":[193],"However":[194],"decreases":[197],"miRNA-96":[198,206,267],"significantly":[200],"(p":[201],"\u2264":[202],"0.01).":[203],"Overxpression":[204],"down":[207],"protein.":[213],"Additionally":[214],"important":[220],"HIF1alpha,":[224],"a":[225],"transcription":[226],"factor":[227],"induced":[228,264],"post":[229],"known":[232],"be":[234],"involved":[235],"resistance.":[238],"currently":[241],"investigating":[242],"implications":[244],"inhibition":[247],"conjunction":[249],"vivo.":[253],"CONCLUSIONS:":[254],"Based":[255],"on":[256],"our":[257],"findings":[258],"conclude":[260],"suppression":[265],"causes":[268],"increased":[269,276],"PRMT5.":[272],"suggests":[274],"may":[280],"contribute":[281],"HIF-mediated":[283]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
